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PDB: 278 件
5WA4
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Pyridine synthase, TbtD, from thiomuracin biosynthesis bound to an N-terminal leader peptide fragment
分子名称: Pyridine synthase TbtD, TbtA 16-mer peptide
著者Cogan, D.P, Nair, S.K.
登録日2017-06-24
公開日2017-11-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.646 Å)
主引用文献Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5W8C
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BU of 5w8c by Molmil
The structure of a COA-dependent acyl-homoserine lactone synthase, BjaI, with MTA and isovaleryl-CoA
分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, Autoinducer synthase, CHLORIDE ION, ...
著者Dong, S.-H, Nair, S.K.
登録日2017-06-21
公開日2017-08-23
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Molecular basis for the substrate specificity of quorum signal synthases.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5W8D
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BU of 5w8d by Molmil
The structure of a COA-dependent acyl-homoserine lactone synthase, BjaI, with MTA
分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, Autoinducer synthase, GLYCEROL
著者Dong, S.-H, Nair, S.K.
登録日2017-06-21
公開日2017-08-23
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Molecular basis for the substrate specificity of quorum signal synthases.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5W99
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Pyridine synthase, PbtD, from GE2270 biosynthesis bound to TSP
分子名称: 2,2'-(6-(2'-(aminomethyl)-[2,4'-bithiazol]-4-yl)pyridine-2,5-diyl)bis(thiazole-4-carboxylic acid), PbtD, SULFATE ION
著者Cogan, D.P, Nair, S.K.
登録日2017-06-22
公開日2017-11-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4YAR
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BU of 4yar by Molmil
2-Hydroxyethylphosphonate dioxygenase (HEPD) E176H
分子名称: 2-hydroxyethylphosphonate dioxygenase, ACETATE ION, CADMIUM ION, ...
著者Chekan, J.R, Nair, S.K.
登録日2015-02-17
公開日2015-03-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献A Common Late-Stage Intermediate in Catalysis by 2-Hydroxyethyl-phosphonate Dioxygenase and Methylphosphonate Synthase.
J.Am.Chem.Soc., 137, 2015
4ZOQ
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BU of 4zoq by Molmil
Crystal Structure of a Lanthipeptide Protease
分子名称: Intracellular serine protease
著者Dong, S.H, Nair, S.K.
登録日2015-05-06
公開日2016-03-23
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Applications of the class II lanthipeptide protease LicP for sequence-specific, traceless peptide bond cleavage.
Chem Sci, 6, 2015
8SAM
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BU of 8sam by Molmil
Crystal structure of class III lanthipeptide synthetase LP-GS-ThurKC in complex with ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Class III lanthipeptide, ...
著者Hernandez Garcia, A, Nair, S.K.
登録日2023-04-01
公開日2023-10-11
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structure and Function of a Class III Metal-Independent Lanthipeptide Synthetase.
Acs Cent.Sci., 9, 2023
8SAP
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BU of 8sap by Molmil
Crystal structure of class III lanthipeptide synthetase ThurKC
分子名称: Class III lanthionine synthetase LanKC
著者Hernandez Garcia, A, Nair, S.K.
登録日2023-04-01
公開日2023-10-11
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献Structure and Function of a Class III Metal-Independent Lanthipeptide Synthetase.
Acs Cent.Sci., 9, 2023
8SAO
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BU of 8sao by Molmil
Crystal structure of class III lanthipeptide synthetase ThurKC in complex with ThurA1 leader peptide
分子名称: Class III lanthionine synthetase LanKC, Class III lanthipeptide
著者Hernandez Garcia, A, Nair, S.K.
登録日2023-04-01
公開日2023-11-01
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.502 Å)
主引用文献Structure and Function of a Class III Metal-Independent Lanthipeptide Synthetase.
Acs Cent.Sci., 9, 2023
8T19
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BU of 8t19 by Molmil
RiPP precursor peptide recognition element (RRE) domain of Ocin-ThiF-like partner protein, PbtF, bound to an 8 residue fragment of its precursor peptide, PbtA
分子名称: MAGNESIUM ION, PbtA, PbtF
著者Cogan, D.P, Nair, S.K, Mitchell, D.A.
登録日2023-06-02
公開日2024-06-12
実験手法X-RAY DIFFRACTION (1.23 Å)
主引用文献Discovery and validation of RRE domains
To Be Published
6OM4
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BU of 6om4 by Molmil
The structure of Microcin C7 biosynthetic enzyme MccB in complex with N-formylated MccA
分子名称: 5'-O-[(S)-amino(hydroxy)phosphoryl]adenosine, MAGNESIUM ION, MccB protein, ...
著者Dong, S.-H, Nair, S.K.
登録日2019-04-18
公開日2019-05-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Biosynthesis of the RiPP trojan horse nucleotide antibiotic microcin C is directed by theN-formyl of the peptide precursor.
Chem Sci, 10, 2019
6PEU
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BU of 6peu by Molmil
Structure of YcaO enzyme from Methanocaldococcus jannaschii in complex with peptide
分子名称: ADENOSINE-5'-TRIPHOSPHATE, GLY-ARG-LEU-GLY-PHE-TYR-GLY-TYR-ASP-LEU-GLN-ASP, MAGNESIUM ION, ...
著者Dong, S.-H, Nair, S.K.
登録日2019-06-20
公開日2019-11-06
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Mechanistic Basis for Ribosomal Peptide Backbone Modifications.
Acs Cent.Sci., 5, 2019
6PE3
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BU of 6pe3 by Molmil
Structure of YcaO enzyme from Methanocaldococcus jannaschii in complex with ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Uncharacterized protein MJ1094
著者Dong, S.-H, Nair, S.K.
登録日2019-06-19
公開日2020-01-08
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Mechanistic Basis for Ribosomal Peptide Backbone Modifications.
Acs Cent.Sci., 5, 2019
3CHU
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BU of 3chu by Molmil
Crystal Structure of Di-iron Aurf
分子名称: MU-OXO-DIIRON, p-Aminobenzoate N-Oxygenase
著者Zhang, H, Brunzelle, J.S, Nair, S.K.
登録日2008-03-10
公開日2008-05-27
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献In vitro reconstitution and crystal structure of p-aminobenzoate N-oxygenase (AurF) involved in aureothin biosynthesis.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3CHT
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BU of 3cht by Molmil
Crystal Structure of Di-iron AurF with partially bound Ligand
分子名称: 4-NITROBENZOIC ACID, MU-OXO-DIIRON, p-Aminobenzoate N-Oxygenase
著者Zhang, H, Brunzelle, J.S, Nair, S.K.
登録日2008-03-10
公開日2008-05-27
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献In vitro reconstitution and crystal structure of p-aminobenzoate N-oxygenase (AurF) involved in aureothin biosynthesis.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3DFI
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BU of 3dfi by Molmil
The crystal structure of antimicrobial reagent A40926 pseudoaglycone deacetylase Dbv21
分子名称: Pseudoaglycone deacetylase Dbv21, ZINC ION
著者Zou, Y, Brunzelle, J.S, Nair, S.K.
登録日2008-06-12
公開日2008-07-22
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structures of lipoglycopeptide antibiotic deacetylases: implications for the biosynthesis of a40926 and teicoplanin.
Chem.Biol., 15, 2008
3DFK
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BU of 3dfk by Molmil
The crystal structure of teicoplanin pseudoaglycone deacetylase Orf2* bound to one of its products decanoic acid
分子名称: DECANOIC ACID, Teicoplanin pseudoaglycone deacetylase Orf2, ZINC ION
著者Zou, Y, Brunzelle, J.S, Nair, S.K.
登録日2008-06-12
公開日2008-07-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structures of lipoglycopeptide antibiotic deacetylases: implications for the biosynthesis of a40926 and teicoplanin.
Chem.Biol., 15, 2008
6E6Y
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BU of 6e6y by Molmil
Dieckmann cyclase, NcmC
分子名称: Dieckmann cyclase, NcmC, SULFATE ION
著者Cogan, D.P, Nair, S.K.
登録日2018-07-25
公開日2019-07-31
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural Basis for Enzymatic Off-Loading of Hybrid Polyketides by Dieckmann Condensation.
Acs Chem.Biol., 2020
6EC7
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BU of 6ec7 by Molmil
Glutamylation domain, TbtB, from thiomuracin biosynthesis
分子名称: Lantibiotic dehydratase domain protein
著者Cogan, D.P, Nair, S.K.
登録日2018-08-07
公開日2019-08-14
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Characterization of glutamyl-tRNA-dependent dehydratases using nonreactive substrate mimics.
Proc.Natl.Acad.Sci.USA, 116, 2019
6E6U
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BU of 6e6u by Molmil
Variant C89S of Dieckmann cyclase, NcmC
分子名称: Dieckmann cyclase, NcmC, SULFATE ION
著者Cogan, D.P, Nair, S.K.
登録日2018-07-25
公開日2019-07-31
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Structural Basis for Enzymatic Off-Loading of Hybrid Polyketides by Dieckmann Condensation.
Acs Chem.Biol., 2020
6EC8
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BU of 6ec8 by Molmil
Glutamylation domain, TbtB, from thiomuracin biosynthesis bound to 5'-phosphodesmethylglutamycin
分子名称: 3'-deoxy-3'-[(L-alpha-glutamyl)amino]adenosine 5'-(dihydrogen phosphate), Lantibiotic dehydratase domain protein
著者Cogan, D.P, Nair, S.K.
登録日2018-08-07
公開日2019-06-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.148 Å)
主引用文献Characterization of glutamyl-tRNA-dependent dehydratases using nonreactive substrate mimics.
Proc.Natl.Acad.Sci.USA, 116, 2019
8FTS
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BU of 8fts by Molmil
SgvM methyltransferase with SAH and alpha-ketoleucine
分子名称: 2-OXO-4-METHYLPENTANOIC ACID, Methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Kuzelka, K, Nair, S.K.
登録日2023-01-13
公開日2023-11-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献A biocatalytic platform for asymmetric alkylation of alpha-keto acids by mining and engineering of methyltransferases
Nat Commun, 14, 2023
8FTR
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BU of 8ftr by Molmil
SgvM methyltransferase with MTA and alpha-ketoleucine
分子名称: 2-OXO-4-METHYLPENTANOIC ACID, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methyltransferase, ...
著者Kuzelka, K, Nair, S.K.
登録日2023-01-13
公開日2023-11-01
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献A biocatalytic platform for asymmetric alkylation of alpha-keto acids by mining and engineering of methyltransferases.
Nat Commun, 14, 2023
8FTV
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BU of 8ftv by Molmil
SgvM methyltransferase triple variant (M144V/F329V/T331A) with SAH and 2-oxo-4-phenylbutanoic acid
分子名称: 2-oxo-4-phenylbutanoic acid, Methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Kuzelka, K, Nair, S.K.
登録日2023-01-13
公開日2023-11-01
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献A biocatalytic platform for asymmetric alkylation of alpha-keto acids by mining and engineering of methyltransferases
Nat Commun, 14, 2023
6E6T
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BU of 6e6t by Molmil
Dieckmann cyclase, NcmC, bound to cerulenin
分子名称: (4S,5R)-4,5-dihydroxy-5-[(3E,6E)-octa-3,6-dien-1-yl]pyrrolidin-2-one, NcmC, SULFATE ION
著者Cogan, D.P, Nair, S.K.
登録日2018-07-25
公開日2019-07-31
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural Basis for Enzymatic Off-Loading of Hybrid Polyketides by Dieckmann Condensation.
Acs Chem.Biol., 2020

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