8SAP
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8SAO
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6D6N
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![BU of 6d6n by Molmil](/molmil-images/mine/6d6n) | The structure of ligand binding domain of LasR in complex with TP-1 homolog, compound 16 | Descriptor: | 2,4-dibromo-6-{[(2-nitrobenzene-1-carbonyl)amino]methyl}phenyl 4-methoxybenzoate, PHENYLALANINE, Transcriptional activator protein LasR | Authors: | Dong, S.H, Nair, S.K. | Deposit date: | 2018-04-21 | Release date: | 2018-08-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR. Cell Chem Biol, 25, 2018
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6D6A
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6D6M
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5DLY
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5DM1
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5DM0
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![BU of 5dm0 by Molmil](/molmil-images/mine/5dm0) | Crystal structure of the plantazolicin methyltransferase BamL in complex with triazolic desmethylPZN analog and SAH | Descriptor: | S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ethyl 2-(2-{2-[(1S)-1-amino-4-carbamimidamidobutyl]-1,3-thiazol-4-yl}-5-methyl-1,3-oxazol-4-yl)-1,3-thiazole-4-carboxylate, ... | Authors: | Hao, Y, Nair, S.K. | Deposit date: | 2015-09-07 | Release date: | 2015-09-23 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Insights into methyltransferase specificity and bioactivity of derivatives of the antibiotic plantazolicin. Acs Chem.Biol., 10, 2015
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5DM4
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![BU of 5dm4 by Molmil](/molmil-images/mine/5dm4) | Crystal structure of the plantazolicin methyltransferase BpumL in complex with pentazolic desmethylPZN analog and SAH | Descriptor: | 1-[(4S)-4-(4-{4-[4-(5,5'-dimethyl-2,4'-bi-1,3-oxazol-2'-yl)-1,3-thiazol-2-yl]-5-methyl-1,3-oxazol-2-yl}-1,3-thiazol-2-yl)-4-(methylamino)butyl]guanidine, GLYCEROL, Methyltransferase domain family, ... | Authors: | Hao, Y, Nair, S.K. | Deposit date: | 2015-09-07 | Release date: | 2015-09-23 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Insights into methyltransferase specificity and bioactivity of derivatives of the antibiotic plantazolicin. Acs Chem.Biol., 10, 2015
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5DM2
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6XP8
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4WD9
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7RC3
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![BU of 7rc3 by Molmil](/molmil-images/mine/7rc3) | Aeronamide N-methyltransferase, AerE (Y137F) | Descriptor: | ASPARTIC ACID, CALCIUM ION, HEXAETHYLENE GLYCOL, ... | Authors: | Cogan, D.P, Reyes, R, Nair, S.K. | Deposit date: | 2021-07-07 | Release date: | 2022-03-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Structure and mechanism for iterative amide N -methylation in the biosynthesis of channel-forming peptide cytotoxins. Proc.Natl.Acad.Sci.USA, 119, 2022
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7RC4
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![BU of 7rc4 by Molmil](/molmil-images/mine/7rc4) | Aeronamide N-methyltransferase, AerE (D141A) | Descriptor: | CALCIUM ION, HEXAETHYLENE GLYCOL, Methyltransferase family protein, ... | Authors: | Cogan, D.P, Reyes, R, Nair, S.K. | Deposit date: | 2021-07-07 | Release date: | 2022-03-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Structure and mechanism for iterative amide N -methylation in the biosynthesis of channel-forming peptide cytotoxins. Proc.Natl.Acad.Sci.USA, 119, 2022
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7RC6
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![BU of 7rc6 by Molmil](/molmil-images/mine/7rc6) | Aeronamide N-methyltransferase, AerE, bound to modified peptide substrate, AerA-DL,34 | Descriptor: | Aeronamide A peptide, Methyltransferase family protein, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Cogan, D.P, Reyes, R, Nair, S.K. | Deposit date: | 2021-07-07 | Release date: | 2022-03-30 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Structure and mechanism for iterative amide N -methylation in the biosynthesis of channel-forming peptide cytotoxins. Proc.Natl.Acad.Sci.USA, 119, 2022
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7RC2
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![BU of 7rc2 by Molmil](/molmil-images/mine/7rc2) | Aeronamide N-methyltransferase, AerE | Descriptor: | CALCIUM ION, Methyltransferase family protein, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Cogan, D.P, Reyes, R, Nair, S.K. | Deposit date: | 2021-07-07 | Release date: | 2022-03-30 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | Structure and mechanism for iterative amide N -methylation in the biosynthesis of channel-forming peptide cytotoxins. Proc.Natl.Acad.Sci.USA, 119, 2022
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7RC5
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![BU of 7rc5 by Molmil](/molmil-images/mine/7rc5) | Aeronamide N-methyltransferase, AerE (N231A) | Descriptor: | CALCIUM ION, Methyltransferase family protein, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Cogan, D.P, Reyes, R, Nair, S.K. | Deposit date: | 2021-07-07 | Release date: | 2022-03-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Structure and mechanism for iterative amide N -methylation in the biosynthesis of channel-forming peptide cytotoxins. Proc.Natl.Acad.Sci.USA, 119, 2022
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7RTY
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7QOS
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7UD6
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6OM4
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6PEU
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6PE3
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8CZL
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![BU of 8czl by Molmil](/molmil-images/mine/8czl) | Human LanCL1 bound to methyl glutathione (MeGSH) | Descriptor: | Glutathione S-transferase LANCL1, L-GAMMA-GLUTAMYL-S-METHYLCYSTEINYLGLYCINE, ZINC ION | Authors: | Ongpipattanakul, C, Nair, S.K. | Deposit date: | 2022-05-24 | Release date: | 2023-01-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | The mechanism of thia-Michael addition catalyzed by LanC enzymes. Proc.Natl.Acad.Sci.USA, 120, 2023
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4ZOQ
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![BU of 4zoq by Molmil](/molmil-images/mine/4zoq) | Crystal Structure of a Lanthipeptide Protease | Descriptor: | Intracellular serine protease | Authors: | Dong, S.H, Nair, S.K. | Deposit date: | 2015-05-06 | Release date: | 2016-03-23 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Applications of the class II lanthipeptide protease LicP for sequence-specific, traceless peptide bond cleavage. Chem Sci, 6, 2015
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