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PDB: 17 件
1TFM
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CRYSTAL STRUCTURE OF A RIBOSOME INACTIVATING PROTEIN IN ITS NATURALLY INHIBITED FORM
分子名称: 2-AMINO-4-ISOPROPYL-PTERIDINE-6-CARBOXYLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Mishra, V, Bilgrami, S, Paramasivam, M, Yadav, S, Sharma, R.S, Kaur, P, Srinivasan, A, Babu, C.R, Singh, T.P.
登録日2004-05-27
公開日2004-07-13
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献CRYSTAL STRUCTURE OF A RIBOSOME INACTIVATING PROTEIN IN ITS NATURALLY INHIBITED FORM
To be Published
1PC8
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Crystal Structure of a novel form of mistletoe lectin from Himalayan Viscum album L. at 3.8A resolution
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Himalayan mistletoe ribosome-inactivating protein, ...
著者Mishra, V, Ethayathulla, A.S, Paramasivam, M, Singh, G, Yadav, S, Kaur, P, Sharma, R.S, Babu, C.R, Singh, T.P.
登録日2003-05-16
公開日2004-06-22
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Structure of a novel ribosome-inactivating protein from a hemi-parasitic plant inhabiting the northwestern Himalayas.
Acta Crystallogr.,Sect.D, 60, 2004
7VE2
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Crystal Structure of Lopinavir bound Plasmepsin II (PMII) from Plasmodium falciparum
分子名称: 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE, Plasmepsin II
著者Mishra, V, Rathore, I, Bhaumik, P.
登録日2021-09-07
公開日2023-02-01
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Inhibition of Plasmodium falciparum plasmepsins by drugs targeting HIV-1 protease: A way forward for antimalarial drug discovery.
Curr Res Struct Biol, 7, 2024
7VE0
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Crystal Structure of Ritonavir bound Plasmepsin II (PMII) from Plasmodium falciparum
分子名称: 1,2-ETHANEDIOL, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Plasmepsin II, ...
著者Mishra, V, Rathore, I, Bhaumik, P.
登録日2021-09-07
公開日2023-02-01
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Inhibition of Plasmodium falciparum plasmepsins by drugs targeting HIV-1 protease: A way forward for antimalarial drug discovery.
Curr Res Struct Biol, 7, 2024
1YF8
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Crystal structure of Himalayan mistletoe RIP reveals the presence of a natural inhibitor and a new functionally active sugar-binding site
分子名称: 2-AMINO-4-ISOPROPYL-PTERIDINE-6-CARBOXYLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Mishra, V, Bilgrami, S, Sharma, R.S, Kaur, P, Yadav, S, Betzel, C, Babu, C.R, Singh, T.P.
登録日2004-12-31
公開日2005-03-08
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of himalayan mistletoe ribosome-inactivating protein reveals the presence of a natural inhibitor and a new functionally active sugar-binding site.
J.Biol.Chem., 280, 2005
4OY3
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Crystal Structure of the Helicobacter pylori MTAN-D198N mutant with S-Adenosylhomocysteine in the active site
分子名称: Aminodeoxyfutalosine nucleosidase, CHLORIDE ION, S-ADENOSYL-L-HOMOCYSTEINE
著者Mishra, V, Ronning, D.R.
登録日2014-02-10
公開日2014-12-17
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Crystal structures of the Helicobacter pylori MTAN enzyme reveal specific interactions between S-adenosylhomocysteine and the 5'-alkylthio binding subsite.
Biochemistry, 51, 2012
4OJT
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Helicobacter pylori MTAN complexed with S-ribosylhomocysteine and adenine
分子名称: ADENINE, MTA/SAH nucleosidase, S-ribosylhomocysteine
著者Mishra, V, Ronning, D.R.
登録日2014-01-21
公開日2014-03-26
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal structures of the Helicobacter pylori MTAN enzyme reveal specific interactions between S-adenosylhomocysteine and the 5'-alkylthio binding subsite.
Biochemistry, 51, 2012
5YIE
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Crystal Structure of KNI-10742 bound Plasmepsin II (PMII) from Plasmodium falciparum
分子名称: (4R)-3-[(2S,3S)-3-[2-[4-[2-azanylethyl(ethyl)amino]-2,6-dimethyl-phenoxy]ethanoylamino]-2-oxidanyl-4-phenyl-butanoyl]-5,5-dimethyl-N-[(1S,2R)-2-oxidanyl-2,3-dihydro-1H-inden-1-yl]-1,3-thiazolidine-4-carboxamide, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Plasmepsin II, ...
著者Mishra, V, Rathore, I, Bhaumik, P.
登録日2017-10-04
公開日2018-07-11
最終更新日2019-05-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins - biochemical and structural insights.
Febs J., 285, 2018
5YIC
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BU of 5yic by Molmil
Crystal Structure of KNI-10333 bound Plasmepsin II (PMII) from Plasmodium falciparum
分子名称: (4R)-3-[(2S,3S)-3-[[(2R)-2-[2-(4-aminophenyl)ethanoylamino]-3-methylsulfanyl-propanoyl]amino]-2-oxidanyl-4-phenyl-butanoyl]-5,5-dimethyl-N-[(1S,2R)-2-oxidanyl-2,3-dihydro-1H-inden-1-yl]-1,3-thiazolidine-4-carboxamide, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, GLYCEROL, ...
著者Mishra, V, Rathore, I, Bhaumik, P.
登録日2017-10-03
公開日2018-07-11
最終更新日2019-05-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins - biochemical and structural insights.
Febs J., 285, 2018
5YID
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BU of 5yid by Molmil
Crystal Structure of KNI-10395 bound Plasmepsin II (PMII) from Plasmodium falciparum
分子名称: (4R)-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-3-[(2S,3S)-2-hydroxy-3-{[S-methyl-N-(phenylacetyl)-L-cysteinyl]amino}-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Plasmepsin II, ...
著者Mishra, V, Rathore, I, Bhaumik, P.
登録日2017-10-04
公開日2018-07-11
最終更新日2019-05-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins - biochemical and structural insights.
Febs J., 285, 2018
4P54
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BU of 4p54 by Molmil
Crystal Structure of the Helicobacter pylori MTAN-D198N mutant with 5'-methylthioadenosine in the active site.
分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, Aminodeoxyfutalosine nucleosidase, CHLORIDE ION
著者Ronning, D.R, Mishra, V.
登録日2014-03-14
公開日2014-04-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal structures of the Helicobacter pylori MTAN enzyme reveal specific interactions between S-adenosylhomocysteine and the 5'-alkylthio binding subsite.
Biochemistry, 51, 2012
7VGE
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BU of 7vge by Molmil
Structure of the PDZ deleted variant of HtrA2 protease (S306A)
分子名称: Serine protease HTRA2, mitochondrial
著者Parui, A.L, Mishra, V, Bhaumik, P, Bose, K.
登録日2021-09-15
公開日2022-06-01
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (4 Å)
主引用文献Inter-subunit crosstalk via PDZ synergistically governs allosteric activation of proapoptotic HtrA2.
Structure, 30, 2022
6KUC
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BU of 6kuc by Molmil
Crystal structure of Plasmodium falciparum histo-aspartic protease (HAP) zymogen (Form 2)
分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, HAP protein
著者Rathore, I, Mishra, V, Bhaumik, P.
登録日2019-08-31
公開日2020-05-27
最終更新日2021-02-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Activation mechanism of plasmepsins, pepsin-like aspartic proteases from Plasmodium, follows a unique trans-activation pathway.
Febs J., 288, 2021
6KUD
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BU of 6kud by Molmil
Crystal structure of Plasmodium falciparum histo-aspartic protease (HAP) zymogen (Form 3)
分子名称: GLYCEROL, HAP protein
著者Rathore, I, Mishra, V, Bhaumik, P.
登録日2019-08-31
公開日2020-05-27
最終更新日2021-02-03
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Activation mechanism of plasmepsins, pepsin-like aspartic proteases from Plasmodium, follows a unique trans-activation pathway.
Febs J., 288, 2021
6KUB
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BU of 6kub by Molmil
Crystal structure of Plasmodium falciparum histo-aspartic protease (HAP) zymogen (Form 1)
分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, HAP protein
著者Rathore, I, Mishra, V, Bhaumik, P.
登録日2019-08-31
公開日2020-05-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Activation mechanism of plasmepsins, pepsin-like aspartic proteases from Plasmodium, follows a unique trans-activation pathway.
Febs J., 288, 2021
5YIA
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Crystal Structure of KNI-10343 bound Plasmepsin II (PMII) from Plasmodium falciparum
分子名称: (4R)-3-[(2S,3S)-3-[[(2R)-2-[2-(4-hydroxyphenyl)ethanoylamino]-3-methylsulfanyl-propanoyl]amino]-2-oxidanyl-4-phenyl-butanoyl]-5,5-dimethyl-N-[(1S,2R)-2-oxidanyl-2,3-dihydro-1H-inden-1-yl]-1,3-thiazolidine-4-carboxamide, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, GLYCEROL, ...
著者Rathore, I, Mishra, V, Bhaumik, P.
登録日2017-10-03
公開日2018-07-11
最終更新日2019-05-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins - biochemical and structural insights.
Febs J., 285, 2018
5YIB
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Crystal Structure of KNI-10743 bound Plasmepsin II (PMII) from Plasmodium falciparum
分子名称: (4R)-3-[(2S,3S)-3-[2-[4-[2-(dimethylamino)ethyl-methyl-amino]-2,6-dimethyl-phenoxy]ethanoylamino]-2-oxidanyl-4-phenyl-butanoyl]-5,5-dimethyl-N-[(1S,2R)-2-oxidanyl-2,3-dihydro-1H-inden-1-yl]-1,3-thiazolidine-4-carboxamide, 1,2-ETHANEDIOL, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ...
著者Rathore, I, Mishra, V, Bhaumik, P.
登録日2017-10-03
公開日2018-07-11
最終更新日2019-05-29
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins - biochemical and structural insights.
Febs J., 285, 2018

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