5YID

Crystal Structure of KNI-10395 bound Plasmepsin II (PMII) from Plasmodium falciparum

Summary for 5YID

Entry DOI	10.2210/pdb5yid/pdb
Related PRD ID	PRD_001055
Descriptor	Plasmepsin II, (4R)-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-3-[(2S,3S)-2-hydroxy-3-{[S-methyl-N-(phenylacetyl)-L-cysteinyl]amino}-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ... (5 entities in total)
Functional Keywords	plasmepsin, plasmepsin ii, kni-10395, aspartic protease, plasmodium falciparum, drug development, inhibitor, hydrolase
Biological source	Plasmodium falciparum (isolate 3D7)
Total number of polymer chains	1
Total formula weight	38112.33
Authors	Mishra, V.,Rathore, I.,Bhaumik, P. (deposition date: 2017-10-04, release date: 2018-07-11, Last modification date: 2019-05-29)
Primary citation	Mishra, V.,Rathore, I.,Arekar, A.,Sthanam, L.K.,Xiao, H.,Kiso, Y.,Sen, S.,Patankar, S.,Gustchina, A.,Hidaka, K.,Wlodawer, A.,Yada, R.Y.,Bhaumik, P. Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins - biochemical and structural insights. Febs J., 285:3077-3096, 2018 Cited by PubMed: 29943906 DOI: 10.1111/febs.14598 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation