5YID
Crystal Structure of KNI-10395 bound Plasmepsin II (PMII) from Plasmodium falciparum
Summary for 5YID
Entry DOI | 10.2210/pdb5yid/pdb |
Related PRD ID | PRD_001055 |
Descriptor | Plasmepsin II, (4R)-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-3-[(2S,3S)-2-hydroxy-3-{[S-methyl-N-(phenylacetyl)-L-cysteinyl]amino}-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ... (5 entities in total) |
Functional Keywords | plasmepsin, plasmepsin ii, kni-10395, aspartic protease, plasmodium falciparum, drug development, inhibitor, hydrolase |
Biological source | Plasmodium falciparum (isolate 3D7) |
Total number of polymer chains | 1 |
Total formula weight | 38112.33 |
Authors | Mishra, V.,Rathore, I.,Bhaumik, P. (deposition date: 2017-10-04, release date: 2018-07-11, Last modification date: 2019-05-29) |
Primary citation | Mishra, V.,Rathore, I.,Arekar, A.,Sthanam, L.K.,Xiao, H.,Kiso, Y.,Sen, S.,Patankar, S.,Gustchina, A.,Hidaka, K.,Wlodawer, A.,Yada, R.Y.,Bhaumik, P. Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins - biochemical and structural insights. Febs J., 285:3077-3096, 2018 Cited by PubMed: 29943906DOI: 10.1111/febs.14598 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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