7VE2

Crystal Structure of Lopinavir bound Plasmepsin II (PMII) from Plasmodium falciparum

Summary for 7VE2

• Entry DOI: 10.2210/pdb7ve2/pdb
• Descriptor: Plasmepsin II, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE (3 entities in total)
• Functional Keywords: inhibitor, protease, peptidomimetic, hiv-1 protease inhibitor, peptidase, hemoglobin degrader, hydrolase
• Biological source: Plasmodium falciparum (isolate 3D7)
• Total number of polymer chains: 1
• Total formula weight: 38972.48

Authors

Mishra, V.,Rathore, I.,Bhaumik, P. (deposition date: 2021-09-07, release date: 2023-02-01, Last modification date: 2024-03-06)

• Primary citation: Mishra, V.,Deshmukh, A.,Rathore, I.,Chakraborty, S.,Patankar, S.,Gustchina, A.,Wlodawer, A.,Yada, R.Y.,Bhaumik, P.; Inhibition of Plasmodium falciparum plasmepsins by drugs targeting HIV-1 protease: A way forward for antimalarial drug discovery.; Curr Res Struct Biol, 7:100128-100128, 2024; PubMed: 38304146; DOI: 10.1016/j.crstbi.2024.100128

Experimental method