5YIB
Crystal Structure of KNI-10743 bound Plasmepsin II (PMII) from Plasmodium falciparum
Summary for 5YIB
Entry DOI | 10.2210/pdb5yib/pdb |
Descriptor | Plasmepsin II, (4R)-3-[(2S,3S)-3-[2-[4-[2-(dimethylamino)ethyl-methyl-amino]-2,6-dimethyl-phenoxy]ethanoylamino]-2-oxidanyl-4-phenyl-butanoyl]-5,5-dimethyl-N-[(1S,2R)-2-oxidanyl-2,3-dihydro-1H-inden-1-yl]-1,3-thiazolidine-4-carboxamide, GLYCEROL, ... (6 entities in total) |
Functional Keywords | plasmepsin, plasmepsin ii, kni-10743, aspartic protease, plasmodium falciparum, drug development, inhibitor, hydrolase |
Biological source | Plasmodium falciparum (isolate 3D7) |
Total number of polymer chains | 1 |
Total formula weight | 38788.07 |
Authors | Rathore, I.,Mishra, V.,Bhaumik, P. (deposition date: 2017-10-03, release date: 2018-07-11, Last modification date: 2019-05-29) |
Primary citation | Mishra, V.,Rathore, I.,Arekar, A.,Sthanam, L.K.,Xiao, H.,Kiso, Y.,Sen, S.,Patankar, S.,Gustchina, A.,Hidaka, K.,Wlodawer, A.,Yada, R.Y.,Bhaumik, P. Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins - biochemical and structural insights. Febs J., 285:3077-3096, 2018 Cited by PubMed: 29943906DOI: 10.1111/febs.14598 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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