6IAO
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![BU of 6iao by Molmil](/molmil-images/mine/6iao) | Structure of Cytochrome P450 BM3 M11 mutant in complex with DTT at resolution 2.16A | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Bifunctional cytochrome P450/NADPH--P450 reductase, CHLORIDE ION, ... | Authors: | Mirza, O, Rafiq, M, Frydenvang, K. | Deposit date: | 2018-11-27 | Release date: | 2019-06-05 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol. Plos One, 14, 2019
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1JG9
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1JGI
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1QGJ
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![BU of 1qgj by Molmil](/molmil-images/mine/1qgj) | ARABIDOPSIS THALIANA PEROXIDASE N | Descriptor: | CALCIUM ION, GLUTATHIONE, PEROXIDASE N, ... | Authors: | Mirza, O, Oestergaard, L, Welinder, K.G, Henriksen, A, Gajhede, M. | Deposit date: | 1999-04-29 | Release date: | 2000-03-08 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Arabidopsis thaliana peroxidase N: structure of a novel neutral peroxidase. Acta Crystallogr.,Sect.D, 56, 2000
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1FSK
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![BU of 1fsk by Molmil](/molmil-images/mine/1fsk) | COMPLEX FORMATION BETWEEN A FAB FRAGMENT OF A MONOCLONAL IGG ANTIBODY AND THE MAJOR ALLERGEN FROM BIRCH POLLEN BET V 1 | Descriptor: | ANTIBODY HEAVY CHAIN FAB, IMMUNOGLOBULIN KAPPA LIGHT CHAIN, MAJOR POLLEN ALLERGEN BET V 1-A | Authors: | Mirza, O, Henriksen, A, Ipsen, H, Larsen, J, Wissenbach, M, Spangfort, M, Gajhede, M. | Deposit date: | 2000-09-11 | Release date: | 2000-10-02 | Last modified: | 2018-03-07 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Dominant epitopes and allergic cross-reactivity: complex formation between a Fab fragment of a monoclonal murine IgG antibody and the major allergen from birch pollen Bet v 1. J.Immunol., 165, 2000
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2CFQ
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![BU of 2cfq by Molmil](/molmil-images/mine/2cfq) | Sugar Free Lactose Permease at neutral pH | Descriptor: | LACTOSE PERMEASE, MERCURY (II) ION | Authors: | Mirza, O, Guan, L, Verner, G, Iwata, S, Kaback, H.R. | Deposit date: | 2006-02-22 | Release date: | 2006-03-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structural Evidence for Induced Fit and a Mechanism for Sugar/H(+) Symport in Lacy. Embo J., 25, 2006
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2CFP
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![BU of 2cfp by Molmil](/molmil-images/mine/2cfp) | Sugar Free Lactose Permease at acidic pH | Descriptor: | LACTOSE PERMEASE, MERCURY (II) ION | Authors: | Mirza, O, Guan, L, Verner, G, Iwata, S, Kaback, H.R. | Deposit date: | 2006-02-22 | Release date: | 2006-03-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural Evidence for Induced Fit and a Mechanism for Sugar/H(+) Symport in Lacy. Embo J., 25, 2006
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1MW2
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![BU of 1mw2 by Molmil](/molmil-images/mine/1mw2) | Amylosucrase soaked with 100mM sucrose | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, amylosucrase, ... | Authors: | Skov, L.K, Mirza, O, Sprogoe, D, Dar, I, Remaud-Simeon, M, Albenne, C, Monsan, P, Gajhede, M. | Deposit date: | 2002-09-27 | Release date: | 2002-12-18 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Oligosaccharide and Sucrose Complexes of Amylosucrase. STRUCTURAL IMPLICATIONS FOR THE POLYMERASE ACTIVITY J.BIOL.CHEM., 277, 2002
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1MW3
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![BU of 1mw3 by Molmil](/molmil-images/mine/1mw3) | Amylosucrase soaked with 1M sucrose | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, amylosucrase, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | Authors: | Skov, L.K, Mirza, O, Sprogoe, D, Dar, I, Remaud-Simeon, M, Albenne, C, Monsan, P, Gajhede, M. | Deposit date: | 2002-09-27 | Release date: | 2002-12-18 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Oligosaccharide and Sucrose Complexes of Amylosucrase. STRUCTURAL IMPLICATIONS FOR THE POLYMERASE ACTIVITY J.BIOL.CHEM., 277, 2002
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1MVY
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![BU of 1mvy by Molmil](/molmil-images/mine/1mvy) | Amylosucrase mutant E328Q co-crystallized with maltoheptaose. | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... | Authors: | Skov, L.K, Mirza, O, Sprogoe, D, Dar, I, Remaud-Simeon, M, Albenne, C, Monsan, P, Gajhede, M. | Deposit date: | 2002-09-27 | Release date: | 2002-12-18 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Oligosaccharide and Sucrose Complexes of Amylosucrase. STRUCTURAL IMPLICATIONS FOR THE POLYMERASE ACTIVITY J.BIOL.CHEM., 277, 2002
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1MW1
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![BU of 1mw1 by Molmil](/molmil-images/mine/1mw1) | Amylosucrase soaked with 14mM sucrose. | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, amylosucrase, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | Authors: | Skov, L.K, Mirza, O, Sprogoe, D, Dar, I, Remaud-Simeon, M, Albenne, C, Monsan, P, Gajhede, M. | Deposit date: | 2002-09-27 | Release date: | 2002-12-18 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Oligosaccharide and Sucrose Complexes of Amylosucrase. STRUCTURAL IMPLICATIONS FOR THE POLYMERASE ACTIVITY J.BIOL.CHEM., 277, 2002
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1ZS2
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![BU of 1zs2 by Molmil](/molmil-images/mine/1zs2) | Amylosucrase Mutant E328Q in a ternary complex with sucrose and maltoheptaose | Descriptor: | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, amylosucrase, ... | Authors: | Skov, L.K, Mirza, O, Sprogoe, D, van der Veen, B.A, Remaud-Simeon, M, Albenne, C, Monsan, P, Gajhede, M. | Deposit date: | 2005-05-23 | Release date: | 2006-05-02 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Crystal structure of the Glu328Gln mutant of Neisseria polysaccharea amylosucrase in complex with sucrose and maltoheptaose BIOCATAL.BIOTRANSFOR., 24, 2006
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6RUQ
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![BU of 6ruq by Molmil](/molmil-images/mine/6ruq) | Structure of GluA2cryst in complex the antagonist ZK200775 and the negative allosteric modulator GYKI53655 at 4.65 A resolution | Descriptor: | (8R)-5-(4-aminophenyl)-N,8-dimethyl-8,9-dihydro-2H,7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide, Glutamate receptor 2, beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Krintel, C, Venskutonyte, R, Mirza, O.A, Gajhede, M, Kastrup, J.S. | Deposit date: | 2019-05-28 | Release date: | 2020-06-24 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (4.65 Å) | Cite: | Binding of a negative allosteric modulator and competitive antagonist can occur simultaneously at the ionotropic glutamate receptor GluA2. Febs J., 288, 2021
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2GDV
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2GDU
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![BU of 2gdu by Molmil](/molmil-images/mine/2gdu) | E232Q mutant of sucrose phosphorylase from BIFIDOBACTERIUM ADOLESCENTIS in complex with sucrose | Descriptor: | beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, sucrose phosphorylase | Authors: | Skov, L.K, Mirza, O, Gajhede, M, Kastrup, J.S. | Deposit date: | 2006-03-17 | Release date: | 2006-09-26 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Rearrangements of Sucrose Phosphorylase from Bifidobacterium adolescentis during Sucrose Conversion J.Biol.Chem., 281, 2006
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5M99
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![BU of 5m99 by Molmil](/molmil-images/mine/5m99) | Functional Characterization and Crystal Structure of Thermostable Amylase from Thermotoga petrophila, reveals High Thermostability and an Archaic form of Dimerization | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Alpha-amylase, ... | Authors: | Hameed, U, Price, I, Mirza, O.A. | Deposit date: | 2016-11-01 | Release date: | 2017-07-19 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Functional characterization and crystal structure of thermostable amylase from Thermotoga petrophila, reveals high thermostability and an unusual form of dimerization. Biochim. Biophys. Acta, 1865, 2017
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8RB6
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![BU of 8rb6 by Molmil](/molmil-images/mine/8rb6) | Structure of Aldo-Keto Reductase 1C3 (AKR1C3) in complex with an inhibitor M689, with the 3-hydroxy-benzoisoxazole moiety. Resolution 2.0A | Descriptor: | 1,2-ETHANEDIOL, 4-[[4-(3-hydroxyphenyl)phenyl]amino]-1,2-benzoxazol-3-ol, Aldo-keto reductase family 1 member C3, ... | Authors: | Frydenvang, K, Mirza, O.A. | Deposit date: | 2023-12-03 | Release date: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer. Eur.J.Med.Chem., 268, 2024
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2JLN
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![BU of 2jln by Molmil](/molmil-images/mine/2jln) | Structure of Mhp1, a nucleobase-cation-symport-1 family transporter | Descriptor: | MERCURY (II) ION, MHP1, SODIUM ION | Authors: | Weyand, S, Shimamura, T, Yajima, S, Suzuki, S, Mirza, O, Krusong, K, Carpenter, E.P, Rutherford, N.G, Hadden, J.M, O'Reilly, J, Ma, P, Saidijam, M, Patching, S.G, Hope, R.J, Norbertczak, H.T, Roach, P.C.J, Iwata, S, Henderson, P.J.F, Cameron, A.D. | Deposit date: | 2008-09-11 | Release date: | 2008-10-28 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter. Science, 322, 2008
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8A7D
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![BU of 8a7d by Molmil](/molmil-images/mine/8a7d) | Partial dimer complex of PAPP-A and its inhibitor STC2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Pappalysin-1, ... | Authors: | Kobbero, S.D, Gajhede, M, Mirza, O.A, Boesen, T, Oxvig, C. | Deposit date: | 2022-06-20 | Release date: | 2022-11-02 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism. Nat Commun, 13, 2022
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8A7E
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![BU of 8a7e by Molmil](/molmil-images/mine/8a7e) | PAPP-A dimer in complex with its inhibitor STC2 | Descriptor: | CALCIUM ION, Pappalysin-1, Stanniocalcin-2, ... | Authors: | Kobbero, S.D, Gajhede, M, Mirza, O.A, Boesen, T, Oxvig, C. | Deposit date: | 2022-06-20 | Release date: | 2022-11-02 | Method: | ELECTRON MICROSCOPY (5.02 Å) | Cite: | Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism. Nat Commun, 13, 2022
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1MW0
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![BU of 1mw0 by Molmil](/molmil-images/mine/1mw0) | Amylosucrase mutant E328Q co-crystallized with maltoheptaose then soaked with maltoheptaose. | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, amylosucrase, ... | Authors: | Skov, L.K, Mirza, O, Sprogoe, D, Dar, I, Remaud-Simeon, M, Albenne, C, Monsan, P, Gajhede, M. | Deposit date: | 2002-09-27 | Release date: | 2002-12-18 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Oligosaccharide and Sucrose Complexes of Amylosucrase. STRUCTURAL IMPLICATIONS FOR THE POLYMERASE ACTIVITY J.BIOL.CHEM., 277, 2002
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2VRQ
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![BU of 2vrq by Molmil](/molmil-images/mine/2vrq) | STRUCTURE OF AN INACTIVE MUTANT OF ARABINOFURANOSIDASE FROM THERMOBACILLUS XYLANILYTICUS IN COMPLEX WITH A PENTASACCHARIDE | Descriptor: | ALPHA-L-ARABINOFURANOSIDASE, PHOSPHATE ION, alpha-L-arabinofuranose-(1-3)-[beta-D-xylopyranose-(1-4)]beta-D-xylopyranose-(1-4)-beta-D-xylopyranose, ... | Authors: | Paes, G, Skov, L.K, Odonohue, M.J, Remond, C, Kastrup, J.S, Gajhede, M, Mirza, O. | Deposit date: | 2008-04-09 | Release date: | 2008-07-01 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Structure of the Complex between a Branched Pentasaccharide and Thermobacillus Xylanilyticus Gh-51 Arabinofuranosidase Reveals Xylan-Binding Determinants and Induced Fit. Biochemistry, 47, 2008
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1G5A
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![BU of 1g5a by Molmil](/molmil-images/mine/1g5a) | AMYLOSUCRASE FROM NEISSERIA POLYSACCHAREA | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, AMYLOSUCRASE, ... | Authors: | Skov, L.K, Mirza, O, Henriksen, A, De Montalk, G.P, Remaud-Simeon, M, Sarcabal, P, Willemot, R.-M, Monsan, P, Gajhede, M. | Deposit date: | 2000-10-31 | Release date: | 2001-10-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Amylosucrase, A Glucan-synthesizing Enzyme from the alpha-Amylase Family J.Biol.Chem., 276, 2001
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2VRK
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![BU of 2vrk by Molmil](/molmil-images/mine/2vrk) | Structure of a seleno-methionyl derivative of wild type arabinofuranosidase from Thermobacillus xylanilyticus | Descriptor: | ALPHA-L-ARABINOFURANOSIDASE, PHOSPHATE ION | Authors: | Paes, G, Skov, L.K, ODonohue, M.J, Remond, C, Kastrup, J.S, Gajhede, M, Mirza, O. | Deposit date: | 2008-04-09 | Release date: | 2008-07-01 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The Structure of the Complex between a Branched Pentasaccharide and Thermobacillus Xylanilyticus Gh-51 Arabinofuranosidase Reveals Xylan-Binding Determinants and Induced Fit. Biochemistry, 47, 2008
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1S46
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![BU of 1s46 by Molmil](/molmil-images/mine/1s46) | Covalent intermediate of the E328Q amylosucrase mutant | Descriptor: | amylosucrase, beta-D-glucopyranose | Authors: | Jensen, M.H, Mirza, O, Albenne, C, Remaud-Simeon, M, Monsan, P, Gajhede, M, Skov, L.K. | Deposit date: | 2004-01-15 | Release date: | 2004-03-23 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of the covalent intermediate of amylosucrase from Neisseria polysaccharea. Biochemistry, 43, 2004
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