6RUQ

Structure of GluA2cryst in complex the antagonist ZK200775 and the negative allosteric modulator GYKI53655 at 4.65 A resolution

Summary for 6RUQ

• Entry DOI: 10.2210/pdb6ruq/pdb
• Related: 3KG2 5L1H
• EMDB information: 4875 4920 4921 4922 4923 4924 4925
• Descriptor: Glutamate receptor 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: receptor negative allosteric modulator antagonist non-competitve antagonist, membrane protein
• Biological source: Rattus norvegicus (Norway rat)
• Total number of polymer chains: 4
• Total formula weight: 373084.36

Authors

Krintel, C.,Venskutonyte, R.,Mirza, O.A.,Gajhede, M.,Kastrup, J.S. (deposition date: 2019-05-28, release date: 2020-06-24, Last modification date: 2024-01-24)

• Primary citation: Krintel, C.,Dorosz, J.,Larsen, A.H.,Thorsen, T.S.,Venskutonyte, R.,Mirza, O.,Gajhede, M.,Boesen, T.,Kastrup, J.S.; Binding of a negative allosteric modulator and competitive antagonist can occur simultaneously at the ionotropic glutamate receptor GluA2.; Febs J., 288:995-1007, 2021; PubMed: 32543078; DOI: 10.1111/febs.15455

Experimental method

X-RAY DIFFRACTION (4.65 Å)