6RUQ
Structure of GluA2cryst in complex the antagonist ZK200775 and the negative allosteric modulator GYKI53655 at 4.65 A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Glutamate receptor 2 | polymer | 823 | 92029.0 | 4 | UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Norway rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2 |
| 2 | E, G (E, G) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 3 | F (F) | beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G31886NL) | |||
| 4 | H, J, L, N (A, B, C, D) | (8R)-5-(4-aminophenyl)-N,8-dimethyl-8,9-dihydro-2H,7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide | non-polymer | 352.4 | 4 | Chemie (GYK) | |||
| 5 | I, K, M, O (A, B, C, D) | {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid | non-polymer | 409.3 | 4 | Chemie (ZK1) |
Sequence modifications
A, B, C, D: 10 - 826 (UniProt: P19491)
| PDB | External Database | Details |
|---|---|---|
| Glu 241 | Asn 256 | engineered mutation |
| Leu 382 | Val 397 | conflict |
| - | Leu 399 | deletion |
| - | Thr 400 | deletion |
| - | Glu 401 | deletion |
| - | Leu 402 | deletion |
| - | Pro 403 | deletion |
| - | Ser 404 | deletion |
| Glu 384 | Gly 405 | conflict |
| Asp 385 | Asn 406 | engineered mutation |
| Gln 392 | Asn 413 | engineered mutation |
| Ala 410 | Lys 431 | engineered mutation |
| Ala 413 | Glu 434 | conflict |
| Ala 414 | Met 435 | conflict |
| Ala 416 | Glu 437 | conflict |
| Ala 572 | Gly 593 | conflict |
| Gln 575 | Asn 596 | conflict |
| Ala 577 | Leu 598 | conflict |
| Ala 589 | Cys 610 | engineered mutation |
| Leu 758 | Val 779 | conflict |
| Gly 827 | - | expression tag |
| Leu 828 | - | expression tag |
| Val 829 | - | expression tag |
| Pro 830 | - | expression tag |
| Arg 831 | - | expression tag |
| Gly 832 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 368116.0 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1921.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 3046.6 | |
| All* | Total formula weight | 373084.4 |
