PDB Search results for query - 日本蛋白质结构数据库

PDB: 140 results

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1647
Descriptor:	5-amino-3-[7-(cyclobutyloxy)quinolin-3-yl]-1-cyclohexyl-1H-pyrazole-4-carboxamide, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A.
Deposit date:	2014-09-17
Release date:	2014-10-15
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1647 to be published

4WG3

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1610
Descriptor:	3-(7-ethoxynaphthalen-2-yl)-1-(2-methylpropyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A.
Deposit date:	2014-09-17
Release date:	2014-10-15
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1610 to be published

1EEI

CHOLERA TOXIN B-PENTAMER COMPLEXED WITH METANITROPHENYL-ALPHA-D-GALACTOSE
Descriptor:	3-nitrophenyl alpha-D-galactopyranoside, PROTEIN (CHOLERA TOXIN B)
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	2000-01-31
Release date:	2000-02-16
Last modified:	2023-08-09
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Exploration of the GM1 receptor-binding site of heat-labile enterotoxin and cholera toxin by phenyl-ring-containing galactose derivatives. Acta Crystallogr.,Sect.D, 57, 2001

1EFI

HEAT-LABILE ENTEROTOXIN B-PENTAMER COMPLEXED WITH PARA-AMINOPHENYL-ALPHA-D-GALACTOPYRANOSIDE
Descriptor:	4-aminophenyl alpha-D-galactopyranoside, PROTEIN (HEAT-LABILE ENTEROTOXIN B CHAIN)
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	2000-02-08
Release date:	2000-02-23
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Exploration of the GM1 receptor-binding site of heat-labile enterotoxin and cholera toxin by phenyl-ring-containing galactose derivatives. Acta Crystallogr.,Sect.D, 57, 2001

1EEF

HEAT-LABILE ENTEROTOXIN B-PENTAMER COMPLEXED WITH BOUND LIGAND PEPG
Descriptor:	2-PHENETHYL-2,3-DIHYDRO-PHTHALAZINE-1,4-DIONE, PROTEIN (HEAT-LABILE ENTEROTOXIN B CHAIN), alpha-D-galactopyranose
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	2000-01-31
Release date:	2000-02-16
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Exploration of the GM1 receptor-binding site of heat-labile enterotoxin and cholera toxin by phenyl-ring-containing galactose derivatives. Acta Crystallogr.,Sect.D, 57, 2001

4TZR

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1561
Descriptor:	1-{4-amino-3-[2-(cyclopropyloxy)quinolin-6-yl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-2-methylpropan-2-ol, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A.
Deposit date:	2014-07-10
Release date:	2014-08-27
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis. J. Med. Chem., 59, 2016

3M3I

Hypothetical protein from Leishmania major
Descriptor:	Putative uncharacterized protein
Authors:	Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2010-03-09
Release date:	2010-03-23
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2.35 Å)
Cite:	Hypothetical protein from Leishmania major To be Published

6BFA

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1553
Descriptor:	1-{4-amino-3-[6-(cyclopropyloxy)naphthalen-2-yl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-2-methylpropan-2-ol, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A.
Deposit date:	2017-10-26
Release date:	2017-12-06
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis. J. Med. Chem., 59, 2016

4JBV

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1268
Descriptor:	1-[(1-methylpiperidin-4-yl)methyl]-3-[6-(2-methylpropoxy)naphthalen-2-yl]pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A, Larson, E.T.
Deposit date:	2013-02-20
Release date:	2014-03-19
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes. Eur.J.Med.Chem., 74, 2014

6VYE

6-phosphogluconolactonase from Trypanosoma cruzi
Descriptor:	6-phosphogluconolactonase, GLYCEROL, PHOSPHATE ION
Authors:	Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2020-02-26
Release date:	2020-03-18
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	6-phosphogluconolactonase from Trypanosoma cruzi To be published

1QCB

ESCHERICHIA COLI HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER
Descriptor:	PROTEIN (HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER)
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	1999-04-30
Release date:	2003-06-10
Last modified:	2021-07-28
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Crystal Structures of the B-Pentamer from E. coli Enterotoxin LT-IIb To be Published

1QB5

ESCHERICHIA COLI HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER
Descriptor:	PROTEIN (HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER)
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	1999-04-30
Release date:	2003-06-10
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Crystal Structures of the B-Pentamer from E. coli Enterotoxin LT-IIb To be Published

4WG4

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1613
Descriptor:	3-(7-ethoxynaphthalen-2-yl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A.
Deposit date:	2014-09-17
Release date:	2014-10-15
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1613 to be published

4YJN

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1639
Descriptor:	5-amino-1-tert-butyl-3-[2-(cyclobutyloxy)quinolin-6-yl]-1H-pyrazole-4-carboxamide, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A.
Deposit date:	2015-03-03
Release date:	2015-11-25
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1. Acs Med.Chem.Lett., 6, 2015

4YSJ

Calcium-Dependent Protein Kinase from Eimeria tenella in complex with ADP
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Calmodulin-like domain protein kinase, ...
Authors:	Merritt, E.A.
Deposit date:	2015-03-17
Release date:	2016-04-06
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	CDPK is a druggable target in the apicomplexan parasite Eimeria to be published

6VMT

Leishmania major Programmed Cell Death Protein 5 Homolog
Descriptor:	Programmed Cell Death Protein 5 Homolog
Authors:	Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2020-01-28
Release date:	2020-02-26
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.501 Å)
Cite:	Leishmania major Programmed Cell Death Protein 5 Homolog To be published

1CHQ

SURPRISING LEADS FOR A CHOLERA TOXIN RECEPTOR BINDING ANTAGONIST; CRYSTALLOGRAPHIC STUDIES OF CTB MUTANTS
Descriptor:	CHOLERA TOXIN B PENTAMER
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	1995-02-15
Release date:	1996-03-08
Last modified:	2021-11-03
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Surprising leads for a cholera toxin receptor-binding antagonist: crystallographic studies of CTB mutants. Structure, 3, 1995

1CHP

SURPRISING LEADS FOR A CHOLERA TOXIN RECEPTOR BINDING ANTAGONIST; CRYSTALLOGRAPHIC STUDIES OF CTB MUTANTS
Descriptor:	CHLORIDE ION, CHOLERA TOXIN B PENTAMER
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	1995-02-15
Release date:	1996-03-08
Last modified:	2021-11-03
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Surprising leads for a cholera toxin receptor-binding antagonist: crystallographic studies of CTB mutants. Structure, 3, 1995

4DGG

c-SRC kinase domain in complex with RM-1-176
Descriptor:	3-{6-[(3-chlorobenzyl)oxy]naphthalen-2-yl}-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Proto-oncogene tyrosine-protein kinase Src
Authors:	Merritt, E.A, Larson, E.T.
Deposit date:	2012-01-25
Release date:	2012-10-10
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.65 Å)
Cite:	Active site profiling reveals coupling between domains in SRC-family kinases. Nat.Chem.Biol., 9, 2013

4ONA

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1517
Descriptor:	5-amino-1-tert-butyl-3-(7-ethoxyquinolin-3-yl)-1H-pyrazole-4-carboxamide, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A.
Deposit date:	2014-01-28
Release date:	2014-03-19
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Potent and selective inhibitors of CDPK1 from T. gondii and C. parvum based on a 5-aminopyrazole-4-carboxamide scaffold. ACS Med Chem Lett, 5, 2014

4M84

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1455
Descriptor:	5-amino-1-tert-butyl-3-(quinolin-2-yl)-1H-pyrazole-4-carboxamide, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A.
Deposit date:	2013-08-12
Release date:	2013-10-02
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.998 Å)
Cite:	Potent and selective inhibitors of CDPK1 from T. gondii and C. parvum based on a 5-aminopyrazole-4-carboxamide scaffold. ACS Med Chem Lett, 5, 2014

1HTL

MUTATION OF A BURIED RESIDUE CAUSES LACK OF ACTIVITY BUT NO CONFORMATIONAL CHANGE: CRYSTAL STRUCTURE OF E. COLI HEAT-LABILE ENTEROTOXIN MUTANT VAL 97--> LYS
Descriptor:	HEAT-LABILE ENTEROTOXIN, SUBUNIT A, SUBUNIT B
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	1995-02-15
Release date:	1995-04-20
Last modified:	2024-06-05
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Mutation of a buried residue causes loss of activity but no conformational change in the heat-labile enterotoxin of Escherichia coli. Nat.Struct.Biol., 2, 1995

4EQU

Human STK-10 (LOK) kinase domain in DFG-out conformation with inhibitor DSA-7
Descriptor:	CALCIUM ION, N-{3-[(3-{4-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]-4-methylphenyl}-3-(trifluoromethyl)benzamide, PENTAETHYLENE GLYCOL, ...
Authors:	Merritt, E.A, Larson, E.T.
Deposit date:	2012-04-19
Release date:	2012-11-07
Last modified:	2012-12-19
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Affinity-Based Probes Based on Type II Kinase Inhibitors. J.Am.Chem.Soc., 134, 2012

4Y5Q

Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with AMP
Descriptor:	ADENOSINE MONOPHOSPHATE, CALCIUM ION, Calmodulin-domain protein kinase 1, ...
Authors:	Merritt, E.A, Larson, E.T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2015-02-11
Release date:	2015-02-25
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with AMP To Be Published

4DS2

Ubiquitin conjugating enzyme (putative) from Trypanosoma cruzi
Descriptor:	Ubiquitin-conjugating enzyme E2, putative
Authors:	Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2012-02-17
Release date:	2012-02-29
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.63 Å)
Cite:	Ubiquitin conjugating enzyme (putative) from Trypanosoma cruzi To be Published

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Total results:	140
Displayed results:	25
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Deposition authors:	"Merritt, E"