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PDB: 15 件
5AQ1
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BU of 5aq1 by Molmil
Trypanosoma cruzi Glucose-6-phosphate Dehydrogenase in complex with G6P and NADPH
分子名称: 6-O-phosphono-beta-D-glucopyranose, GLUCOSE-6-PHOSPHATE DEHYDROGENASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Mercaldi, G.F, Dawson, A, Hunter, W.N, Cordeiro, A.T.
登録日2015-09-18
公開日2016-07-20
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献The Structure of a Trypanosoma Cruzi Glucose-6-Phosphate Dehydrogenase Reveals Differences from the Mammalian Enzyme.
FEBS Lett., 590, 2016
3NVL
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BU of 3nvl by Molmil
Crystal Structure of Phosphoglycerate Mutase from Trypanosoma brucei
分子名称: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, COBALT (II) ION, SULFATE ION
著者Mercaldi, G.F, Pereira, H.M, Cordeiro, A.T, Andricopulo, A.D, Thiemann, O.H.
登録日2010-07-08
公開日2011-07-27
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of phosphoglycerate mutase from Trypanosoma brucei.
Febs J., 279, 2012
8GJB
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L-threonine 3-Dehydrogenase from Trypanosoma cruzi in complex with NAD and acetate
分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, GLYCEROL, ...
著者Mercaldi, G.F, Faria, J.N, Fagundes, M, Bezerra, E.H.S, Cordeiro, A.T.
登録日2023-03-15
公開日2024-03-20
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structure, allosteric regulation and metabolic activity of L-threonine 3-Dehydrogenase from Trypanosoma cruzi
To Be Published
6WQ6
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BU of 6wq6 by Molmil
Xanthomonas citri Methionyl-tRNA synthetase in complex with methionine
分子名称: METHIONINE, Methionine--tRNA ligase, ZINC ION
著者Mercaldi, G.F, Benedetti, C.E.
登録日2020-04-28
公開日2021-04-21
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Molecular basis for diaryldiamine selectivity and competition with tRNA in a type 2 methionyl-tRNA synthetase from a Gram-negative bacterium.
J.Biol.Chem., 296, 2021
6WQS
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BU of 6wqs by Molmil
Xanthomonas citri Methionyl-tRNA synthetase in complex with REP8839
分子名称: 2-{[3-({[4-bromo-5-(1-fluoroethenyl)-3-methylthiophen-2-yl]methyl}amino)propyl]amino}quinolin-4(1H)-one, Methionine--tRNA ligase, ZINC ION
著者Mercaldi, G.F, Benedetti, C.E.
登録日2020-04-29
公開日2021-04-21
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Molecular basis for diaryldiamine selectivity and competition with tRNA in a type 2 methionyl-tRNA synthetase from a Gram-negative bacterium.
J.Biol.Chem., 296, 2021
6WQT
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BU of 6wqt by Molmil
Xanthomonas citri Methionyl-tRNA synthetase in complex with REP3123
分子名称: 5-[(3-{[(4R)-6,8-dibromo-3,4-dihydro-2H-1-benzopyran-4-yl]amino}propyl)amino]thieno[3,2-b]pyridin-7(6H)-one, Methionine--tRNA ligase, ZINC ION
著者Mercaldi, G.F, Benedetti, C.E.
登録日2020-04-29
公開日2021-04-21
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Molecular basis for diaryldiamine selectivity and competition with tRNA in a type 2 methionyl-tRNA synthetase from a Gram-negative bacterium.
J.Biol.Chem., 296, 2021
6WQI
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BU of 6wqi by Molmil
Xanthomonas citri Methionyl-tRNA synthetase (apo)
分子名称: Methionine--tRNA ligase, ZINC ION
著者Mercaldi, G.F, Benedetti, C.E.
登録日2020-04-28
公開日2021-04-21
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Molecular basis for diaryldiamine selectivity and competition with tRNA in a type 2 methionyl-tRNA synthetase from a Gram-negative bacterium.
J.Biol.Chem., 296, 2021
6W29
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BU of 6w29 by Molmil
Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC013)
分子名称: 3,5-bis(fluoranyl)-~{N}-[3-[(4-methoxyphenyl)sulfamoyl]phenyl]benzamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CITRIC ACID, ...
著者Mercaldi, G.F, Fagundes, M, Faria, J.N, Cordeiro, A.T.
登録日2020-03-05
公開日2021-03-10
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box.
Acs Infect Dis., 7, 2021
6W2N
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Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC009)
分子名称: 3,5-bis(fluoranyl)-~{N}-[3-[(2-fluoranyl-4-methoxy-phenyl)sulfamoyl]phenyl]benzamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CITRIC ACID, ...
著者Mercaldi, G.F, Fagundes, M, Faria, J.N, Cordeiro, A.T.
登録日2020-03-06
公開日2021-03-10
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box.
Acs Infect Dis., 7, 2021
6W59
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Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC063)
分子名称: 3,5-bis(fluoranyl)-~{N}-[3-[[4-(trifluoromethyloxy)phenyl]sulfamoyl]phenyl]benzamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Malic enzyme
著者Mercaldi, G.F, Fagundes, M, Faria, J.N, Cordeiro, A.T.
登録日2020-03-12
公開日2021-03-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box.
Acs Infect Dis., 7, 2021
6W49
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BU of 6w49 by Molmil
Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC010)
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CITRIC ACID, Malic enzyme, ...
著者Mercaldi, G.F, Fagundes, M, Faria, J.N, Cordeiro, A.T.
登録日2020-03-10
公開日2021-04-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box.
Acs Infect Dis., 7, 2021
6W57
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BU of 6w57 by Molmil
Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC069)
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Malic enzyme, ~{N}-[5-[[4-[bis(fluoranyl)methoxy]phenyl]sulfamoyl]-2-chloranyl-phenyl]-3,5-bis(fluoranyl)benzamide
著者Mercaldi, G.F, Fagundes, M, Faria, J.N, Cordeiro, A.T.
登録日2020-03-12
公開日2021-04-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box.
Acs Infect Dis., 7, 2021
6W53
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Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC070)
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Malic enzyme, N-(2-chloro-5-{[4-(trifluoromethoxy)phenyl]sulfamoyl}phenyl)-3,5-difluorobenzamide
著者Mercaldi, G.F, Fagundes, M, Faria, J.N, Cordeiro, A.T.
登録日2020-03-12
公開日2021-04-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box.
Acs Infect Dis., 7, 2021
6W56
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BU of 6w56 by Molmil
Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC062)
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Malic enzyme, ~{N}-[3-[[4-[bis(fluoranyl)methoxy]phenyl]sulfamoyl]phenyl]-3,5-bis(fluoranyl)benzamide
著者Mercaldi, G.F, Fagundes, M, Faria, J.N, Cordeiro, A.T.
登録日2020-03-12
公開日2021-04-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box.
Acs Infect Dis., 7, 2021
8GIL
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BU of 8gil by Molmil
L-threonine 3-Dehydrogenase from Trypanosoma cruzi (apo form)
分子名称: L-threonine 3-dehydrogenase, POTASSIUM ION
著者Faria, J.N, Mercaldi, G.F, Fagundes, M, Bezerra, E.H.S, Cordeiro, A.T.
登録日2023-03-14
公開日2024-03-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure, allosteric regulation and metabolic activity of L-threonine 3-Dehydrogenase from Trypanosoma cruzi
To Be Published

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件を2024-07-24に公開中

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