3NVL
 
 | | Crystal Structure of Phosphoglycerate Mutase from Trypanosoma brucei | | 分子名称: | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, COBALT (II) ION, SULFATE ION | | 著者 | Mercaldi, G.F, Pereira, H.M, Cordeiro, A.T, Andricopulo, A.D, Thiemann, O.H. | | 登録日 | 2010-07-08 | | 公開日 | 2011-07-27 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of phosphoglycerate mutase from Trypanosoma brucei.
Febs J., 279, 2012
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5AQ1
 | | Trypanosoma cruzi Glucose-6-phosphate Dehydrogenase in complex with G6P and NADPH | | 分子名称: | 6-O-phosphono-beta-D-glucopyranose, GLUCOSE-6-PHOSPHATE DEHYDROGENASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Mercaldi, G.F, Dawson, A, Hunter, W.N, Cordeiro, A.T. | | 登録日 | 2015-09-18 | | 公開日 | 2016-07-20 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | The Structure of a Trypanosoma Cruzi Glucose-6-Phosphate Dehydrogenase Reveals Differences from the Mammalian Enzyme.
FEBS Lett., 590, 2016
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8GJB
 | | L-threonine 3-Dehydrogenase from Trypanosoma cruzi in complex with NAD and acetate | | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, GLYCEROL, ... | | 著者 | Mercaldi, G.F, Faria, J.N, Fagundes, M, Bezerra, E.H.S, Cordeiro, A.T. | | 登録日 | 2023-03-15 | | 公開日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structure, allosteric regulation and metabolic activity of L-threonine 3-Dehydrogenase from Trypanosoma cruzi
To Be Published
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6WQ6
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6WQS
 | | Xanthomonas citri Methionyl-tRNA synthetase in complex with REP8839 | | 分子名称: | 2-{[3-({[4-bromo-5-(1-fluoroethenyl)-3-methylthiophen-2-yl]methyl}amino)propyl]amino}quinolin-4(1H)-one, Methionine--tRNA ligase, ZINC ION | | 著者 | Mercaldi, G.F, Benedetti, C.E. | | 登録日 | 2020-04-29 | | 公開日 | 2021-04-21 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Molecular basis for diaryldiamine selectivity and competition with tRNA in a type 2 methionyl-tRNA synthetase from a Gram-negative bacterium.
J.Biol.Chem., 296, 2021
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6WQT
 | | Xanthomonas citri Methionyl-tRNA synthetase in complex with REP3123 | | 分子名称: | 5-[(3-{[(4R)-6,8-dibromo-3,4-dihydro-2H-1-benzopyran-4-yl]amino}propyl)amino]thieno[3,2-b]pyridin-7(6H)-one, Methionine--tRNA ligase, ZINC ION | | 著者 | Mercaldi, G.F, Benedetti, C.E. | | 登録日 | 2020-04-29 | | 公開日 | 2021-04-21 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Molecular basis for diaryldiamine selectivity and competition with tRNA in a type 2 methionyl-tRNA synthetase from a Gram-negative bacterium.
J.Biol.Chem., 296, 2021
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6WQI
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6W59
 | | Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC063) | | 分子名称: | 3,5-bis(fluoranyl)-~{N}-[3-[[4-(trifluoromethyloxy)phenyl]sulfamoyl]phenyl]benzamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Malic enzyme | | 著者 | Mercaldi, G.F, Fagundes, M, Faria, J.N, Cordeiro, A.T. | | 登録日 | 2020-03-12 | | 公開日 | 2021-03-17 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box.
Acs Infect Dis., 7, 2021
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6W29
 | | Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC013) | | 分子名称: | 3,5-bis(fluoranyl)-~{N}-[3-[(4-methoxyphenyl)sulfamoyl]phenyl]benzamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CITRIC ACID, ... | | 著者 | Mercaldi, G.F, Fagundes, M, Faria, J.N, Cordeiro, A.T. | | 登録日 | 2020-03-05 | | 公開日 | 2021-03-10 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | | 主引用文献 | Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box.
Acs Infect Dis., 7, 2021
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6W2N
 | | Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC009) | | 分子名称: | 3,5-bis(fluoranyl)-~{N}-[3-[(2-fluoranyl-4-methoxy-phenyl)sulfamoyl]phenyl]benzamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CITRIC ACID, ... | | 著者 | Mercaldi, G.F, Fagundes, M, Faria, J.N, Cordeiro, A.T. | | 登録日 | 2020-03-06 | | 公開日 | 2021-03-10 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box.
Acs Infect Dis., 7, 2021
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6W49
 | | Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC010) | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CITRIC ACID, Malic enzyme, ... | | 著者 | Mercaldi, G.F, Fagundes, M, Faria, J.N, Cordeiro, A.T. | | 登録日 | 2020-03-10 | | 公開日 | 2021-04-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box.
Acs Infect Dis., 7, 2021
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6W57
 | | Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC069) | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Malic enzyme, ~{N}-[5-[[4-[bis(fluoranyl)methoxy]phenyl]sulfamoyl]-2-chloranyl-phenyl]-3,5-bis(fluoranyl)benzamide | | 著者 | Mercaldi, G.F, Fagundes, M, Faria, J.N, Cordeiro, A.T. | | 登録日 | 2020-03-12 | | 公開日 | 2021-04-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box.
Acs Infect Dis., 7, 2021
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6W53
 | | Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC070) | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Malic enzyme, N-(2-chloro-5-{[4-(trifluoromethoxy)phenyl]sulfamoyl}phenyl)-3,5-difluorobenzamide | | 著者 | Mercaldi, G.F, Fagundes, M, Faria, J.N, Cordeiro, A.T. | | 登録日 | 2020-03-12 | | 公開日 | 2021-04-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box.
Acs Infect Dis., 7, 2021
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6W56
 | | Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC062) | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Malic enzyme, ~{N}-[3-[[4-[bis(fluoranyl)methoxy]phenyl]sulfamoyl]phenyl]-3,5-bis(fluoranyl)benzamide | | 著者 | Mercaldi, G.F, Fagundes, M, Faria, J.N, Cordeiro, A.T. | | 登録日 | 2020-03-12 | | 公開日 | 2021-04-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box.
Acs Infect Dis., 7, 2021
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4X44
 | | Crystal Structure of Mutant R89Q of human Adenine phosphoribosyltransferase | | 分子名称: | ADENOSINE MONOPHOSPHATE, Adenine phosphoribosyltransferase, GLYCEROL, ... | | 著者 | Pimenta, A, Pereira, H.M, Mercaldi, G, Thiemann, O.H. | | 登録日 | 2014-12-02 | | 公開日 | 2015-12-02 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.0535 Å) | | 主引用文献 | Crystal Structure of Mutant R89Q of human Adenine phosphoribosyltransferase
To Be Published
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8GIL
 | | L-threonine 3-Dehydrogenase from Trypanosoma cruzi (apo form) | | 分子名称: | L-threonine 3-dehydrogenase, POTASSIUM ION | | 著者 | Faria, J.N, Mercaldi, G.F, Fagundes, M, Bezerra, E.H.S, Cordeiro, A.T. | | 登録日 | 2023-03-14 | | 公開日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure, allosteric regulation and metabolic activity of L-threonine 3-Dehydrogenase from Trypanosoma cruzi
To Be Published
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4X45
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