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PDB: 182 results

2K3Y
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Solution structure of EAF3 chromo barrel domain bound to histone h3 with a dimethyllysine analog H3K36ME2
Descriptor: Chromatin modification-related protein EAF3
Authors:Mer, G, Xu, C.
Deposit date:2008-05-19
Release date:2008-09-16
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Structural Basis for the Recognition of Methylated Histone H3K36 by the Eaf3 Subunit of Histone Deacetylase Complex Rpd3S.
Structure, 16, 2008
2K3X
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Solution structure of EAF3 chromo barrel domain
Descriptor: Chromatin modification-related protein EAF3
Authors:Mer, G, Xu, C.
Deposit date:2008-05-19
Release date:2008-09-16
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Structural Basis for the Recognition of Methylated Histone H3K36 by the Eaf3 Subunit of Histone Deacetylase Complex Rpd3S.
Structure, 16, 2008
2IG0
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Structure of 53BP1/methylated histone peptide complex
Descriptor: Dimethylated Histone H4-K20 peptide, SULFATE ION, Tumor suppressor p53-binding protein 1
Authors:Mer, G.
Deposit date:2006-09-22
Release date:2007-01-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair.
Cell(Cambridge,Mass.), 127, 2006
1DPU
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SOLUTION STRUCTURE OF THE C-TERMINAL DOMAIN OF HUMAN RPA32 COMPLEXED WITH UNG2(73-88)
Descriptor: REPLICATION PROTEIN A (RPA32) C-TERMINAL DOMAIN, URACIL DNA GLYCOSYLASE (UNG2)
Authors:Mer, G, Edwards, A.M, Chazin, W.J.
Deposit date:1999-12-27
Release date:2000-11-10
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA.
Cell(Cambridge,Mass.), 103, 2000
1PMC
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BU of 1pmc by Molmil
PROTEINASE INHIBITOR PMP-C (NMR, 36 STRUCTURES)
Descriptor: PROTEINASE INHIBITOR PMP-C
Authors:Mer, G, Hietter, H, Lefevre, J.-F.
Deposit date:1995-09-17
Release date:1996-01-29
Last modified:2024-10-23
Method:SOLUTION NMR
Cite:Solution structure of PMP-C: a new fold in the group of small serine proteinase inhibitors.
J.Mol.Biol., 258, 1996
4QO6
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Structural studies of CdsD, a structural protein of the Type III secretion system (TTSS) of Chlamydia trachomatis
Descriptor: Adenylate cyclase-like protein, DI(HYDROXYETHYL)ETHER, ISOPROPYL ALCOHOL
Authors:Merilainen, G, Wierenga, R.K.
Deposit date:2014-06-19
Release date:2015-06-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:The extended structure of the periplasmic region of CdsD, a structural protein of the type III secretion system of Chlamydia trachomatis.
Protein Sci., 25, 2016
4QQ0
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CdsD - The structural protein of the Type III secretion system of Chlamydia trachomatis: C-terminal domain
Descriptor: Adenylate cyclase-like protein, SULFATE ION
Authors:Merilainen, G, Wierenga, R.K.
Deposit date:2014-06-26
Release date:2015-07-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:The extended structure of the periplasmic region of CdsD, a structural protein of the type III secretion system of Chlamydia trachomatis.
Protein Sci., 25, 2016
2WKT
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BU of 2wkt by Molmil
BIOSYNTHETIC THIOLASE FROM Z. RAMIGERA. COMPLEX OF THE N316A MUTANT WITH COENZYME A.
Descriptor: ACETYL-COA ACETYLTRANSFERASE, CHLORIDE ION, COENZYME A, ...
Authors:Merilainen, G, Poikela, V, Kursula, P, Wierenga, R.K.
Deposit date:2009-06-18
Release date:2009-11-03
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Thiolase Reaction Mechanism: The Importance of Asn316 and His348 for Stabilizing the Enolate Intermediate of the Claisen Condensation.
Biochemistry, 48, 2009
2WL6
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BIOSYNTHETIC THIOLASE FROM Z. RAMIGERA. THE N316H-H348N MUTANT.
Descriptor: ACETYL-COA ACETYLTRANSFERASE
Authors:Merilainen, G, Poikela, V, Kursula, P, Wierenga, R.K.
Deposit date:2009-06-22
Release date:2009-11-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:The Thiolase Reaction Mechanism: The Importance of Asn316 and His348 for Stabilizing the Enolate Intermediate of the Claisen Condensation.
Biochemistry, 48, 2009
2WL5
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BU of 2wl5 by Molmil
BIOSYNTHETIC THIOLASE FROM Z. RAMIGERA. COMPLEX OF THE H348N MUTANT WITH COENZYME A.
Descriptor: ACETYL-COA ACETYLTRANSFERASE, CHLORIDE ION, COENZYME A, ...
Authors:Merilainen, G, Poikela, V, Kursula, P, Wierenga, R.K.
Deposit date:2009-06-22
Release date:2009-11-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Thiolase Reaction Mechanism: The Importance of Asn316 and His348 for Stabilizing the Enolate Intermediate of the Claisen Condensation.
Biochemistry, 48, 2009
2WKV
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BU of 2wkv by Molmil
BIOSYNTHETIC THIOLASE FROM Z. RAMIGERA. COMPLEX OF THE N316D MUTANT WITH COENZYME A.
Descriptor: ACETYL-COA ACETYLTRANSFERASE, COENZYME A, SODIUM ION, ...
Authors:Merilainen, G, Poikela, V, Kursula, P, Wierenga, R.K.
Deposit date:2009-06-18
Release date:2009-11-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Thiolase Reaction Mechanism: The Importance of Asn316 and His348 for Stabilizing the Enolate Intermediate of the Claisen Condensation.
Biochemistry, 48, 2009
2WKU
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BU of 2wku by Molmil
BIOSYNTHETIC THIOLASE FROM Z. RAMIGERA. THE N316H MUTANT.
Descriptor: ACETYL-COA ACETYLTRANSFERASE, D-mannose, SULFATE ION
Authors:Merilainen, G, Poikela, V, Kursula, P, Wierenga, R.K.
Deposit date:2009-06-18
Release date:2009-11-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Thiolase Reaction Mechanism: The Importance of Asn316 and His348 for Stabilizing the Enolate Intermediate of the Claisen Condensation.
Biochemistry, 48, 2009
2WL4
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BU of 2wl4 by Molmil
BIOSYNTHETIC THIOLASE FROM Z. RAMIGERA. COMPLEX OF THE H348A MUTANT WITH COENZYME A.
Descriptor: ACETYL-COA ACETYLTRANSFERASE, CHLORIDE ION, COENZYME A, ...
Authors:Merilainen, G, Poikela, V, Kursula, P, Wierenga, R.K.
Deposit date:2009-06-22
Release date:2009-11-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Thiolase Reaction Mechanism: The Importance of Asn316 and His348 for Stabilizing the Enolate Intermediate of the Claisen Condensation.
Biochemistry, 48, 2009
1HV2
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BU of 1hv2 by Molmil
SOLUTION STRUCTURE OF YEAST ELONGIN C IN COMPLEX WITH A VON HIPPEL-LINDAU PEPTIDE
Descriptor: ELONGIN C, VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR
Authors:Botuyan, M.V, Mer, G, Yi, G.-S, Koth, C.M, Case, D.A, Edwards, A.M, Chazin, W.J, Arrowsmith, C.H.
Deposit date:2001-01-05
Release date:2001-09-06
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution structure and dynamics of yeast elongin C in complex with a von Hippel-Lindau peptide.
J.Mol.Biol., 312, 2001
4V2D
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BU of 4v2d by Molmil
FLRT2 LRR domain
Descriptor: FIBRONECTIN LEUCINE RICH TRANSMEMBRANE PROTEIN 2
Authors:Seiradake, E, del Toro, D, Nagel, D, Cop, F, Haertl, R, Ruff, T, Seyit-Bremer, G, Harlos, K, Border, E.C, Acker-Palmer, A, Jones, E.Y, Klein, R.
Deposit date:2014-10-08
Release date:2014-11-05
Last modified:2015-07-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Flrt Structure: Balancing Repulsion and Cell Adhesion in Cortical and Vascular Development
Neuron, 84, 2014
4UV9
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BU of 4uv9 by Molmil
LSD1(KDM1A)-CoREST in complex with 1-Ethyl-Tranylcypromine
Descriptor: LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(4aS,10aS)-4a-[(1S,3E)-3-imino-1-phenylpentyl]-7,8-dimethyl-2,4-dioxo-1,3,4,4a,5,10a-hexahydrobenzo[g]pteridin-10(2H)-yl]pentyl dihydrogen diphosphate
Authors:Vianello, P, Botrugno, O, Cappa, A, Ciossani, G, Dessanti, P, Mai, A, Mattevi, A, Meroni, G, Minucci, S, Thaler, F, Tortorici, M, Trifiro, P, Valente, S, Villa, M, Varasi, M, Mercurio, C.
Deposit date:2014-08-05
Release date:2014-09-10
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A.
Eur.J.Med.Chem., 86C, 2014
4UVB
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BU of 4uvb by Molmil
LSD1(KDM1A)-CoREST in complex with 1-Methyl-Tranylcypromine (1S,2R)
Descriptor: LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-[(1R,3S,3aS,7aS)-1-amino-1,10,11-trimethyl-4,6-dioxo-3-phenyl-2,3,5,6,7,7a-hexahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate
Authors:Vianello, P, Botrugno, O, Cappa, A, Ciossani, G, Dessanti, P, Mai, A, Mattevi, A, Meroni, G, Minucci, S, Thaler, F, Tortorici, M, Trifiro, P, Valente, S, Villa, M, Varasi, M, Mercurio, C.
Deposit date:2014-08-05
Release date:2014-09-10
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A.
Eur.J.Med.Chem., 86C, 2014
3ZRM
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BU of 3zrm by Molmil
Identification of 2-(4-pyridyl)thienopyridinones as GSK-3beta inhibitors
Descriptor: 7-(4-HYDROXYPHENYL)-2-PYRIDIN-4-YL-5H-THIENO[3,2-C]PYRIDIN-4-ONE, GLYCEROL, GLYCOGEN SYNTHASE KINASE-3 BETA, ...
Authors:Gentile, G, Bernasconi, G, Pozzan, A, Merlo, G, Marzorati, P, Bamborough, P, Bax, B, Bridges, A, Brough, C, Carter, P, Cutler, G, Neu, M, Takada, M.
Deposit date:2011-06-17
Release date:2011-06-29
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Identification of 2-(4-Pyridyl)Thienopyridinones as Gsk-3Beta Inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
3ZRK
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BU of 3zrk by Molmil
Identification of 2-(4-pyridyl)thienopyridinones as GSK-3beta inhibitors
Descriptor: 2-(4-PYRIDINYL)FURO[3,2-C]PYRIDIN-4(5H)-ONE, GLYCEROL, GLYCOGEN SYNTHASE KINASE-3 BETA, ...
Authors:Gentile, G, Bernasconi, G, Pozzan, A, Merlo, G, Marzorati, P, Bamborough, P, Bax, B, Bridges, A, Brough, C, Carter, P, Cutler, G, Neu, M, Takada, M.
Deposit date:2011-06-16
Release date:2011-06-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Identification of 2-(4-Pyridyl)Thienopyridinones as Gsk-3Beta Inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
3ZRL
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BU of 3zrl by Molmil
Identification of 2-(4-pyridyl)thienopyridinones as GSK-3beta inhibitors
Descriptor: 7-BROMO-2-PYRIDIN-4-YL-5H-THIENO[3,2-C]PYRIDIN-4-ONE, GLYCEROL, GLYCOGEN SYNTHASE KINASE-3 BETA, ...
Authors:Gentile, G, Bernasconi, G, Pozzan, A, Merlo, G, Marzorati, P, Bamborough, P, Bax, B, Bridges, A, Brough, C, Carter, P, Cutler, G, Neu, M, Takada, M.
Deposit date:2011-06-17
Release date:2011-06-29
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Identification of 2-(4-Pyridyl)Thienopyridinones as Gsk-3Beta Inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
6EJI
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BU of 6eji by Molmil
Structure of a glycosyltransferase
Descriptor: CHLORIDE ION, GLYCEROL, POTASSIUM ION, ...
Authors:Ramirez, A.S, Boilevin, J, Mehdipour, A.R, Hummer, G, Darbre, T, Reymond, J.L, Locher, K.P.
Deposit date:2017-09-21
Release date:2018-02-07
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis of the molecular ruler mechanism of a bacterial glycosyltransferase.
Nat Commun, 9, 2018
6EJK
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Structure of a glycosyltransferase
Descriptor: 2-acetamido-2-deoxy-alpha-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-alpha-D-glucopyranose, NerylNeryl pyrophosphate, Uridine-Diphosphate-Methylene-N-acetyl-galactosamine, ...
Authors:Ramirez, A.S, Boilevin, J, Mehdipour, A.R, Hummer, G, Darbre, T, Reymond, J.L, Locher, K.P.
Deposit date:2017-09-21
Release date:2018-02-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis of the molecular ruler mechanism of a bacterial glycosyltransferase.
Nat Commun, 9, 2018
6MXY
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BU of 6mxy by Molmil
Structure of 53BP1 tandem Tudor domains in complex with small molecule UNC3351
Descriptor: N-[3-(tert-butylamino)propyl]-3-(trifluoromethyl)benzamide, PHOSPHATE ION, TP53-binding protein 1
Authors:Cui, G, Botuyan, M.V, Mer, G.
Deposit date:2018-10-31
Release date:2019-11-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.624 Å)
Cite:An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.
Nat Commun, 14, 2023
6MXZ
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Structure of 53BP1 Tudor domains in complex with small molecule UNC3474
Descriptor: FORMIC ACID, N-[3-(tert-butylamino)propyl]-3-(propan-2-yl)benzamide, TP53-binding protein 1
Authors:Cui, G, Botuyan, M.V, Schuller, D.J, Mer, G.
Deposit date:2018-10-31
Release date:2019-11-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.
Nat Commun, 14, 2023
6MY0
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BU of 6my0 by Molmil
Structure of 53BP1 Tandem Tudor domains with E1549P and D1550N mutations
Descriptor: TP53-binding protein 1
Authors:Cui, G, Botuyan, M.V, Mer, G.
Deposit date:2018-10-31
Release date:2019-11-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.
Nat Commun, 14, 2023

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數據於2024-10-30公開中

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