5T5W
| Structure of an affinity matured lambda-IFN/IFN-lambdaR1/IL-10Rbeta receptor complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interferon lambda receptor 1, Interferon lambda-3, ... | Authors: | Mendoza, J.L, Jude, K.M, Garcia, K.C. | Deposit date: | 2016-08-31 | Release date: | 2017-03-29 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.847 Å) | Cite: | The IFN-lambda-IFN-lambda R1-IL-10R beta Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity. Immunity, 46, 2017
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8SSG
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8SSF
| Minimal protein-only/RNA-free Ribonuclease P from Hydrogenobacter thermophilus | Descriptor: | RNA-free ribonuclease P, SULFATE ION | Authors: | Mendoza, J, Mallik, L, Wilhelm, C.A, Koutmos, M. | Deposit date: | 2023-05-08 | Release date: | 2023-10-18 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Bacterial RNA-free RNase P: Structural and functional characterization of multiple oligomeric forms of a minimal protein-only ribonuclease P. J.Biol.Chem., 299, 2023
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6E3K
| Interferon gamma signalling complex with IFNGR1 and IFNGR2 | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Jude, K.M, Mendoza, J.L, Garcia, K.C. | Deposit date: | 2018-07-14 | Release date: | 2019-02-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Structure of the IFN gamma receptor complex guides design of biased agonists. Nature, 567, 2019
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6E3L
| Interferon gamma signalling complex with IFNGR1 and IFNGR2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, ... | Authors: | Jude, K.M, Mendoza, J.L, Garcia, K.C. | Deposit date: | 2018-07-14 | Release date: | 2019-02-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structure of the IFN gamma receptor complex guides design of biased agonists. Nature, 567, 2019
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1YKR
| Crystal structure of cdk2 with an aminoimidazo pyridine inhibitor | Descriptor: | 4-{[6-(2,6-DICHLOROBENZOYL)IMIDAZO[1,2-A]PYRIDIN-2-YL]AMINO}BENZENESULFONAMIDE, Cell division protein kinase 2 | Authors: | Hamdouchi, C, Zhong, B, Mendoza, J, Jaramillo, C, Zhang, F, Brooks, H.B. | Deposit date: | 2005-01-18 | Release date: | 2006-01-24 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-based design of a new class of highly selective aminoimidazo[1,2-a]pyridine-based inhibitors of cyclin dependent kinases Bioorg.Med.Chem.Lett., 15, 2005
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8SSE
| Methionine synthase, C-terminal fragment, Cobalamin and Reactivation Domains from Thermus thermophilus HB8 | Descriptor: | COBALAMIN, Methionine synthase | Authors: | Yamada, K, Mendoza, J, Koutmos, M. | Deposit date: | 2023-05-08 | Release date: | 2023-10-11 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Structure of full-length cobalamin-dependent methionine synthase and cofactor loading captured in crystallo. Nat Commun, 14, 2023
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8UY1
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8UY2
| Methylenetetrahydrofolate reductase from Chaetomium thermophilum DSM 1495, AdoMet-bound, Inhibited (T) State | Descriptor: | ACETATE ION, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | Authors: | Yamada, K, Mendoza, J, Koutmos, M. | Deposit date: | 2023-11-12 | Release date: | 2024-06-19 | Last modified: | 2024-07-03 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | Structural basis of S-adenosylmethionine-dependent allosteric transition from active to inactive states in methylenetetrahydrofolate reductase. Nat Commun, 15, 2024
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8SSC
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8SSD
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