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PDB: 183 results
1YHL
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Structure of the complex of Trypanosoma cruzi farnesyl diphosphate synthase with risedronate, dmapp and mg+2
Descriptor: 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, DIMETHYLALLYL DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Gabelli, S.B, McLellan, J.S, Montalvetti, A, Oldfield, E, Docampo, R, Amzel, L.M.
Deposit date:2005-01-09
Release date:2005-12-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: Implications for drug design.
Proteins, 62, 2005
1YHK
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Trypanosoma cruzi farnesyl diphosphate synthase
Descriptor: SULFATE ION, farnesyl pyrophosphate synthase
Authors:Gabelli, S.B, McLellan, J.S, Montalvetti, A, Oldfield, E, Docampo, R, Amzel, L.M.
Deposit date:2005-01-09
Release date:2005-12-20
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: Implications for drug design.
Proteins, 62, 2005
6OE5
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BU of 6oe5 by Molmil
Splayed open prefusion RSV F captured by CR9501 and motavizumab Fabs
Descriptor: CR9501 Fab Heavy Chain, CR9501 Fab Light Chain, Fusion glycoprotein F0,Fibritin, ...
Authors:Gilman, M.S.A, McLellan, J.S.
Deposit date:2019-03-27
Release date:2019-04-17
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Transient opening of trimeric prefusion RSV F proteins.
Nat Commun, 10, 2019
7UR4
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Cryo-EM Structure of the Neutralizing Antibody MPV467 in Complex with Prefusion Human Metapneumovirus F Glycoprotein
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, MPV467 Fab Heavy chain, ...
Authors:Rush, S.A, McLellan, J.S.
Deposit date:2022-04-21
Release date:2022-06-08
Last modified:2022-06-29
Method:ELECTRON MICROSCOPY (3.34 Å)
Cite:Structural basis for ultrapotent antibody-mediated neutralization of human metapneumovirus.
Proc.Natl.Acad.Sci.USA, 119, 2022
7UPB
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BU of 7upb by Molmil
Prefusion-stabilized Nipah virus fusion protein complexed with Fab 1H1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 1H1 heavy chain, Fab 1H1 light chain, ...
Authors:Byrne, P.O, McLellan, J.S.
Deposit date:2022-04-14
Release date:2023-03-29
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for antibody recognition of vulnerable epitopes on Nipah virus F protein.
Nat Commun, 14, 2023
7UPK
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Prefusion-stabilized Nipah virus fusion protein complexed with Fab 1A9
Descriptor: Fab 1A9 heavy chain, Fab 1A9 light chain, Fusion glycoprotein F0
Authors:Byrne, P.O, McLellan, J.S.
Deposit date:2022-04-15
Release date:2023-03-29
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for antibody recognition of vulnerable epitopes on Nipah virus F protein.
Nat Commun, 14, 2023
7USL
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BU of 7usl by Molmil
Integrin alphaM/beta2 ectodomain in complex with adenylate cyclase toxin RTX751 and M1F5 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Goldsmith, J.A, McLellan, J.S.
Deposit date:2022-04-25
Release date:2022-08-17
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural basis for non-canonical integrin engagement by Bordetella adenylate cyclase toxin.
Cell Rep, 40, 2022
7USM
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BU of 7usm by Molmil
Integrin alphaM/beta2 ectodomain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Goldsmith, J.A, McLellan, J.S.
Deposit date:2022-04-25
Release date:2022-08-17
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural basis for non-canonical integrin engagement by Bordetella adenylate cyclase toxin.
Cell Rep, 40, 2022
7UOP
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Prefusion-stabilized Nipah virus fusion protein complexed with Fab 4H3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 4H3 heavy chain, Fab 4H3 light chain, ...
Authors:Byrne, P.O, McLellan, J.S.
Deposit date:2022-04-13
Release date:2023-03-29
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for antibody recognition of vulnerable epitopes on Nipah virus F protein.
Nat Commun, 14, 2023
7UP9
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BU of 7up9 by Molmil
Prefusion-stabilized Nipah virus fusion protein complexed with Fab 2D3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 2D3 heavy chain, ...
Authors:Byrne, P.O, McLellan, J.S.
Deposit date:2022-04-14
Release date:2023-03-29
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for antibody recognition of vulnerable epitopes on Nipah virus F protein.
Nat Commun, 14, 2023
7UPD
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BU of 7upd by Molmil
Prefusion-stabilized Nipah virus fusion protein complexed with Fab 2B12
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 2B12 heavy chain, Fab 2B12 light chain, ...
Authors:Byrne, P.O, McLellan, J.S.
Deposit date:2022-04-14
Release date:2023-03-29
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Structural basis for antibody recognition of vulnerable epitopes on Nipah virus F protein.
Nat Commun, 14, 2023
7UPA
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BU of 7upa by Molmil
Prefusion-stabilized Nipah virus fusion protein complexed with Fab 1H8
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 1H8 heavy chain, Fab 1H8 light chain, ...
Authors:Byrne, P.O, McLellan, J.S.
Deposit date:2022-04-14
Release date:2023-03-29
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Structural basis for antibody recognition of vulnerable epitopes on Nipah virus F protein.
Nat Commun, 14, 2023
6PXG
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BU of 6pxg by Molmil
Crystal Structure of MERS-CoV neutralizing antibody G2 Fab
Descriptor: G2 Fab Heavy Chain, G2 Fab Light chain
Authors:Wang, N, McLellan, J.S.
Deposit date:2019-07-26
Release date:2019-09-25
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD.
Cell Rep, 28, 2019
6PXH
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BU of 6pxh by Molmil
Crystal Structure of MERS-CoV S1-NTD bound with G2 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DIHYDROFOLIC ACID, ...
Authors:Wang, N, McLellan, J.S.
Deposit date:2019-07-26
Release date:2019-09-25
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD.
Cell Rep, 28, 2019
6PZK
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BU of 6pzk by Molmil
Cryo-EM Structure of the Respiratory Syncytial Virus Polymerase (L) Protein Bound by the Tetrameric Phosphoprotein (P)
Descriptor: Phosphoprotein, RNA-directed RNA polymerase L
Authors:Gilman, M.S.A, McLellan, J.S.
Deposit date:2019-08-01
Release date:2019-09-11
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of the Respiratory Syncytial Virus Polymerase Complex.
Cell, 179, 2019
5WB0
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BU of 5wb0 by Molmil
Crystal structure of human metapneumovirus fusion glycoprotein stabilized in the prefusion state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, ...
Authors:Battles, M.B, McLellan, J.S.
Deposit date:2017-06-27
Release date:2017-11-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoprotein.
Nat Commun, 8, 2017
8T7A
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BU of 8t7a by Molmil
Cryo-EM structure of RSV preF in complex with Fab 2.4K
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2.4K Fab Heavy Chain, 2.4K Fab Light Chain, ...
Authors:McCool, R.S, McLellan, J.S.
Deposit date:2023-06-20
Release date:2023-09-13
Last modified:2023-11-08
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein elicits antibodies targeting a membrane-proximal epitope.
J.Virol., 97, 2023
8U1R
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BU of 8u1r by Molmil
Prefusion-stabilized Langya virus F protein, variant G99C/I109C
Descriptor: Fusion glycoprotein F
Authors:Byrne, P.O, McLellan, J.S.
Deposit date:2023-09-01
Release date:2023-12-27
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Prefusion stabilization of the Hendra and Langya virus F proteins.
J.Virol., 98, 2024
8TMA
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BU of 8tma by Molmil
Antibody N3-1 bound to RBD in the up conformation
Descriptor: N3-1 Fab heavy chain, N3-1 Fab light chain, Spike glycoprotein
Authors:Hsieh, C.-L, McLellan, J.S.
Deposit date:2023-07-29
Release date:2024-01-17
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:SARS-COV-2 Omicron variants conformationally escape a rare quaternary antibody binding mode.
Commun Biol, 6, 2023
8U1G
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BU of 8u1g by Molmil
Prefusion-stabilized SARS-CoV-2 S2 subunit
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S2
Authors:Hsieh, C.-L, McLellan, J.S.
Deposit date:2023-08-31
Release date:2024-01-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of prefusion-stabilized SARS-CoV-2 S2-only antigen
To Be Published
8TM1
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BU of 8tm1 by Molmil
Antibody N3-1 bound to RBDs in the up and down conformations
Descriptor: N3-1 Fab heavy chain, N3-1 Fab light chain, Spike glycoprotein
Authors:Hsieh, C.-L, McLellan, J.S.
Deposit date:2023-07-27
Release date:2024-01-17
Method:ELECTRON MICROSCOPY (2.79 Å)
Cite:SARS-COV-2 Omicron variants conformationally escape a rare quaternary antibody binding mode.
Commun Biol, 6, 2023
8TW3
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BU of 8tw3 by Molmil
hMPV fusion protein complexed with single domain antibodies sdHMPV16 and sdHMPV12
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein, Single domain antibody sdHMPV12, ...
Authors:Rush, S.A, McLellan, J.S.
Deposit date:2023-08-19
Release date:2024-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A neutralizing single-domain antibody that targets the trimer interface of the human metapneumovirus fusion protein.
Mbio, 15, 2024
8V5K
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BU of 8v5k by Molmil
Structure of the Human Respirovirus 3 Fusion Protein Bound to Camelid Nanobodies 4C03 and 4C06
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Camelid Nanobody 4C03, Camelid Nanobody 4C06, ...
Authors:Johnson, N.V, Ramamohan, A.R, McLellan, J.S.
Deposit date:2023-11-30
Release date:2024-05-22
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural basis for potent neutralization of human respirovirus type 3 by protective single-domain camelid antibodies.
Nat Commun, 15, 2024
8V62
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Structure of the Human Respirovirus 3 Fusion Protein Bound to Camelid Nanobodies 1D10 and 4C06
Descriptor: Camelid nanobody 1D10, Camelid nanobody 4C06, Fusion glycoprotein F0
Authors:Johnson, N.J, Ramamohan, A.R, McLellan, J.S.
Deposit date:2023-12-01
Release date:2024-05-22
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis for potent neutralization of human respirovirus type 3 by protective single-domain camelid antibodies.
Nat Commun, 15, 2024
8V5A
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BU of 8v5a by Molmil
Prefusion-stabilized Respirovirus type 3 Fusion protein
Descriptor: Camelid nanobody 4C06, Fusion glycoprotein F0
Authors:Johnson, N.V, McLellan, J.S.
Deposit date:2023-11-30
Release date:2024-06-19
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Universal paramyxovirus vaccine design by stabilizing regions involved in structural transformation of the fusion protein.
Nat Commun, 15, 2024

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數據於2024-07-31公開中

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