1YHL

Structure of the complex of Trypanosoma cruzi farnesyl diphosphate synthase with risedronate, dmapp and mg+2

Summary for 1YHL

• Entry DOI: 10.2210/pdb1yhl/pdb
• Related: 1YHK
• Descriptor: farnesyl pyrophosphate synthase, MAGNESIUM ION, SULFATE ION, ... (6 entities in total)
• Functional Keywords: farnesyl diphosphate synthase, bisphosphonate, dimethyl allyl pyrophosphate sulfate, fpps, transferase
• Biological source: Trypanosoma cruzi
• Total number of polymer chains: 1
• Total formula weight: 41923.51

Authors

Gabelli, S.B.,McLellan, J.S.,Montalvetti, A.,Oldfield, E.,Docampo, R.,Amzel, L.M. (deposition date: 2005-01-09, release date: 2005-12-20, Last modification date: 2024-02-14)

• Primary citation: Gabelli, S.B.,McLellan, J.S.,Montalvetti, A.,Oldfield, E.,Docampo, R.,Amzel, L.M.; Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: Implications for drug design.; Proteins, 62:80-88, 2005; PubMed: 16288456; DOI: 10.1002/prot.20754

Experimental method

X-RAY DIFFRACTION (1.95 Å)