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PDB: 12 件
4TSE
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BU of 4tse by Molmil
Crystal Structure of the Mib Repeat Domain of Mind bomb 1
分子名称: E3 ubiquitin-protein ligase MIB1
著者McMillan, B.J, Blacklow, S.C.
登録日2014-06-18
公開日2015-03-18
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.057 Å)
主引用文献A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb e3 ligases.
Mol.Cell, 57, 2015
5J45
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Crystal structure of Shrub, fly ortholog of SNF7/CHMP4B
分子名称: GH13992p
著者McMillan, B.J, Blacklow, S.C.
登録日2016-03-31
公開日2016-07-20
最終更新日2016-08-17
実験手法X-RAY DIFFRACTION (2.758 Å)
主引用文献Electrostatic Interactions between Elongated Monomers Drive Filamentation of Drosophila Shrub, a Metazoan ESCRT-III Protein.
Cell Rep, 16, 2016
7M05
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CryoEM structure of PRMT5 bound to covalent PBM-site inhibitor BRD-6988
分子名称: 2-(5-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-{[2-(pyridin-2-yl)ethyl]sulfamoyl}phenyl)acetamide, Methylosome protein 50, Protein arginine N-methyltransferase 5
著者McMillan, B.J, McKinney, D.C, Timm, D.E.
登録日2021-03-10
公開日2021-03-17
最終更新日2021-08-25
実験手法ELECTRON MICROSCOPY (2.39 Å)
主引用文献Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction.
J.Med.Chem., 64, 2021
4XIB
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Crystal structure of the MZM-REP domains of Mind bomb 1 in complex with fly Delta N-box peptide
分子名称: Delta N-box peptide, E3 ubiquitin-protein ligase MIB1, SULFATE ION, ...
著者McMillan, B.J, Blacklow, S.C.
登録日2015-01-06
公開日2015-03-18
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.147 Å)
主引用文献A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb e3 ligases.
Mol.Cell, 57, 2015
4XI6
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BU of 4xi6 by Molmil
Crystal structure of the MZM-REP domains of Mind bomb 1
分子名称: E3 ubiquitin-protein ligase MIB1, SULFATE ION, ZINC ION
著者McMillan, B.J, Blacklow, S.C.
登録日2015-01-06
公開日2015-03-18
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb e3 ligases.
Mol.Cell, 57, 2015
4XI7
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BU of 4xi7 by Molmil
Crystal structure of the MZM-REP domains of Mind bomb 1 in complex with Jagged1 N-box peptide
分子名称: E3 ubiquitin-protein ligase MIB1, Jagged 1 N-box peptide, SULFATE ION, ...
著者McMillan, B.J, Blacklow, S.C.
登録日2015-01-06
公開日2015-03-18
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.051 Å)
主引用文献A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb e3 ligases.
Mol.Cell, 57, 2015
6V0P
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BU of 6v0p by Molmil
PRMT5 complex bound to covalent PBM inhibitor BRD6711
分子名称: 2-(5-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-sulfamoylphenyl)acetamide, CHLORIDE ION, GLYCEROL, ...
著者McMillan, B.J, McKinney, D.C.
登録日2019-11-19
公開日2020-11-25
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction.
J.Med.Chem., 64, 2021
6V0N
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BU of 6v0n by Molmil
PRMT5 bound to PBM peptide from Riok1
分子名称: Methylosome protein 50, Protein arginine N-methyltransferase 5, Riok1 PBM peptide, ...
著者McMIllan, B.J, Raymond, D.D.
登録日2019-11-19
公開日2020-08-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Molecular basis for substrate recruitment to the PRMT5 methylosome.
Mol.Cell, 81, 2021
6V0O
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PRMT5 bound to the PBM peptide from pICln
分子名称: ACETYL GROUP, Methylosome protein 50, PBM peptide, ...
著者McMillan, B.J, Raymond, D.D.
登録日2019-11-19
公開日2020-08-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.86 Å)
主引用文献Molecular basis for substrate recruitment to the PRMT5 methylosome.
Mol.Cell, 81, 2021
5VO5
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Crystal structure of Lgd-Shrub complex, single chain fusion
分子名称: Coiled-coil and C2 domain-containing protein 1-like,GH13992p
著者McMillan, B.J, Seegar, T.C.M, Blacklow, S.C.
登録日2017-05-02
公開日2017-06-14
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.004 Å)
主引用文献Structural Basis for Regulation of ESCRT-III Complexes by Lgd.
Cell Rep, 19, 2017
5VNY
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Crystal structure of DM14-3 domain of Lgd
分子名称: Lethal (2) giant discs 1, isoform B
著者McMillan, B.J, Blacklow, S.C.
登録日2017-05-01
公開日2017-06-14
実験手法X-RAY DIFFRACTION (1.101 Å)
主引用文献Structural Basis for Regulation of ESCRT-III Complexes by Lgd.
Cell Rep, 19, 2017
5TCX
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BU of 5tcx by Molmil
Crystal structure of human tetraspanin CD81
分子名称: CD81 antigen, CHOLESTEROL
著者Zimmerman, B, McMillan, B.J, Seegar, T.C.M, Kruse, A.C, Blacklow, S.C.
登録日2016-09-16
公開日2016-11-09
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.955 Å)
主引用文献Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket.
Cell, 167, 2016

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件を2024-08-28に公開中

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