4MMS
 
 | | Crystal Structure of Prefusion-stabilized RSV F Variant Cav1 at pH 5.5 | | 分子名称: | Fusion glycoprotein F1 fused with Fibritin trimerization domain, Fusion glycoprotein F2, SULFATE ION | | 著者 | Mclellan, J.S, Joyce, M.G, Stewart-Jones, G.B.E, Sastry, M, Yang, Y, Graham, B.S, Kwong, P.D. | | 登録日 | 2013-09-09 | | 公開日 | 2013-11-20 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.397 Å) | | 主引用文献 | Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus.
Science, 342, 2013
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7KQD
 | | Prefusion RSV F Bound to RV521 | | 分子名称: | 1'-{[5-(aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-benzimidazol-2-yl]methyl}-6'-fluorospiro[cyclopropane-1,3'-indol]-2'(1'H)-one, Fusion glycoprotein F0, SULFATE ION | | 著者 | McLellan, J.S. | | 登録日 | 2020-11-14 | | 公開日 | 2021-04-21 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | | 主引用文献 | Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion.
J.Med.Chem., 64, 2021
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4MMQ
 | | Crystal Structure of Prefusion-stabilized RSV F Variant DS | | 分子名称: | Fusion glycoprotein F1 fused with Fibritin trimerization domain, Fusion glycoprotein F2, SULFATE ION | | 著者 | Mclellan, J.S, Joyce, M.G, Stewart-Jones, G.B.E, Sastry, M, Yang, Y, Graham, B.S, Kwong, P.D. | | 登録日 | 2013-09-09 | | 公開日 | 2013-11-20 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.253 Å) | | 主引用文献 | Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus.
Science, 342, 2013
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5UDD
 | | Crystal Structure of RSV F B9320 Bound to MEDI8897 | | 分子名称: | Fusion glycoprotein F0, MEDI8897 Fab Heavy Chain, MEDI8897 Fab Light Chain, ... | | 著者 | McLellan, J.S. | | 登録日 | 2016-12-26 | | 公開日 | 2017-05-17 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (4.3 Å) | | 主引用文献 | A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants.
Sci Transl Med, 9, 2017
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5UDE
 | | Crystal Structure of RSV F B9320 DS-Cav1 | | 分子名称: | Fusion glycoprotein F0, SULFATE ION | | 著者 | McLellan, J.S. | | 登録日 | 2016-12-26 | | 公開日 | 2017-05-17 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.001 Å) | | 主引用文献 | A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants.
Sci Transl Med, 9, 2017
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5UDC
 | | Crystal Structure of RSV F A2 Bound to MEDI8897 | | 分子名称: | CHLORIDE ION, Fusion glycoprotein F0, MEDI8897 Fab Heavy Chain, ... | | 著者 | McLellan, J.S. | | 登録日 | 2016-12-26 | | 公開日 | 2017-05-17 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | | 主引用文献 | A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants.
Sci Transl Med, 9, 2017
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6XKL
 | | SARS-CoV-2 HexaPro S One RBD up | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | 著者 | Wrapp, D, Hsieh, C.-L, Goldsmith, J.A, McLellan, J.S. | | 登録日 | 2020-06-26 | | 公開日 | 2020-07-15 | | 最終更新日 | 2020-09-30 | | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | | 主引用文献 | Structure-based design of prefusion-stabilized SARS-CoV-2 spikes.
Science, 369, 2020
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3V7A
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4DQO
 | | Crystal Structure of PG16 Fab in Complex with V1V2 Region from HIV-1 strain ZM109 | | 分子名称: | 1FD6-V1V2 scaffold ZM109 HIV-1 strain, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PG16 Fab Heavy Chain, ... | | 著者 | Pancera, M, McLellan, J.S, Kwong, P.D. | | 登録日 | 2012-02-16 | | 公開日 | 2013-03-06 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.438 Å) | | 主引用文献 | Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16.
Nat.Struct.Mol.Biol., 20, 2013
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6DC4
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6DC3
 | | RSV prefusion F bound to RSD5 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab RSD5-Germline Heavy Chain, Fab RSD5-Germline Light Chain, ... | | 著者 | Battles, M.B, McLellan, J.S, Jones, H.J. | | 登録日 | 2018-05-04 | | 公開日 | 2019-07-10 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.501 Å) | | 主引用文献 | Alternative conformations of a major antigenic site on RSV F.
Plos Pathog., 15, 2019
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8FU3
 | | Structure Of Respiratory Syncytial Virus Polymerase with Novel Non-Nucleoside Inhibitor | | 分子名称: | 8-methoxy-3-methyl-N-{(2S)-3,3,3-trifluoro-2-[5-fluoro-6-(4-fluorophenyl)-4-(2-hydroxypropan-2-yl)pyridin-2-yl]-2-hydroxypropyl}cinnoline-6-carboxamide, Phosphoprotein, RNA-directed RNA polymerase L | | 著者 | Yu, X, Abeywickrema, P, Bonneux, B, Behera, I, Jacoby, E, Fung, A, Adhikary, S, Bhaumik, A, Carbajo, R.J, Bruyn, S.D, Miller, R, Patrick, A, Pham, Q, Piassek, M, Verheyen, N, Shareef, A, Sutto-Ortiz, P, Ysebaert, N, Vlijmen, H.V, Jonckers, T.H.M, Herschke, F, McLellan, J.S, Decroly, E, Fearns, R, Grosse, S, Roymans, D, Sharma, S, Rigaux, P, Jin, Z. | | 登録日 | 2023-01-16 | | 公開日 | 2023-11-01 | | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | | 主引用文献 | Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor.
Commun Biol, 6, 2023
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7S3N
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7SEJ
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5I08
 | | Prefusion structure of a human coronavirus spike protein | | 分子名称: | Spike glycoprotein,Foldon chimera | | 著者 | Kirchdoerfer, R.N, Cottrell, C.A, Wang, N, Pallesen, J, Yassine, H.M, Turner, H.L, Corbett, K.S, Graham, B.S, McLellan, J.S, Ward, A.B. | | 登録日 | 2016-02-03 | | 公開日 | 2016-03-02 | | 最終更新日 | 2020-04-22 | | 実験手法 | ELECTRON MICROSCOPY (4.04 Å) | | 主引用文献 | Pre-fusion structure of a human coronavirus spike protein.
Nature, 531, 2016
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7RAH
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7S3M
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8VCR
 | | SARS-CoV-2 Spike S2 bound to Fab 54043-5 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 54043-5 Fab Heavy Chain, ... | | 著者 | Johnson, N.V, McLellan, J.S. | | 登録日 | 2023-12-14 | | 公開日 | 2024-07-31 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Discovery and Characterization of a Pan-betacoronavirus S2-binding antibody
To Be Published
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8VVK
 | | CCHFV GP38 bound to ADI-46143 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADI-46143 Fab Heavy Chain, ADI-46143 Fab Light Chain, ... | | 著者 | Hjorth, C.K, McLellan, J.S. | | 登録日 | 2024-01-31 | | 公開日 | 2024-07-17 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | | 主引用文献 | Crimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlapping regions on glycoprotein GP38.
Cell Rep, 43, 2024
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8VVL
 | | CCHFV GP38 bound to c13G8 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | 著者 | Hjorth, C.K, Mishra, A.K, McLellan, J.S. | | 登録日 | 2024-01-31 | | 公開日 | 2024-07-17 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlapping regions on glycoprotein GP38.
Cell Rep, 43, 2024
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8VAO
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8VKE
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8VWW
 | | CCHFV GP38 bound to ADI-46152 and ADI-58048 Fabs | | 分子名称: | ADI-46152 Fab Heavy Chain, ADI-46152 Fab Light Chain, ADI-58048 Fab Heavy Chain, ... | | 著者 | Hjorth, C.K, McLellan, J.S. | | 登録日 | 2024-02-02 | | 公開日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Crimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlapping regions on glycoprotein GP38.
Cell Rep, 43, 2024
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8VIF
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7SJ0
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