5UDC
| Crystal Structure of RSV F A2 Bound to MEDI8897 | 分子名称: | CHLORIDE ION, Fusion glycoprotein F0, MEDI8897 Fab Heavy Chain, ... | 著者 | McLellan, J.S. | 登録日 | 2016-12-26 | 公開日 | 2017-05-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | 主引用文献 | A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants. Sci Transl Med, 9, 2017
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4MMS
| Crystal Structure of Prefusion-stabilized RSV F Variant Cav1 at pH 5.5 | 分子名称: | Fusion glycoprotein F1 fused with Fibritin trimerization domain, Fusion glycoprotein F2, SULFATE ION | 著者 | Mclellan, J.S, Joyce, M.G, Stewart-Jones, G.B.E, Sastry, M, Yang, Y, Graham, B.S, Kwong, P.D. | 登録日 | 2013-09-09 | 公開日 | 2013-11-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.397 Å) | 主引用文献 | Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus. Science, 342, 2013
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4MMQ
| Crystal Structure of Prefusion-stabilized RSV F Variant DS | 分子名称: | Fusion glycoprotein F1 fused with Fibritin trimerization domain, Fusion glycoprotein F2, SULFATE ION | 著者 | Mclellan, J.S, Joyce, M.G, Stewart-Jones, G.B.E, Sastry, M, Yang, Y, Graham, B.S, Kwong, P.D. | 登録日 | 2013-09-09 | 公開日 | 2013-11-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.253 Å) | 主引用文献 | Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus. Science, 342, 2013
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3QWO
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3RRT
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3RRR
| Structure of the RSV F protein in the post-fusion conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0 | 著者 | McLellan, J.S, Yongping, Y, Graham, B.S, Kwong, P.D. | 登録日 | 2011-04-30 | 公開日 | 2011-06-08 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.821 Å) | 主引用文献 | Structure of respiratory syncytial virus fusion glycoprotein in the postfusion conformation reveals preservation of neutralizing epitopes. J.Virol., 85, 2011
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8SAK
| BtCoV-422 in complex with neutralizing antibody JC57-11 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | McFadden, E, McLellan, J.S. | 登録日 | 2023-04-01 | 公開日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | A MERS-CoV antibody neutralizes a pre-emerging group 2c bat coronavirus. Sci Transl Med, 15, 2023
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8FU3
| Structure Of Respiratory Syncytial Virus Polymerase with Novel Non-Nucleoside Inhibitor | 分子名称: | 8-methoxy-3-methyl-N-{(2S)-3,3,3-trifluoro-2-[5-fluoro-6-(4-fluorophenyl)-4-(2-hydroxypropan-2-yl)pyridin-2-yl]-2-hydroxypropyl}cinnoline-6-carboxamide, Phosphoprotein, RNA-directed RNA polymerase L | 著者 | Yu, X, Abeywickrema, P, Bonneux, B, Behera, I, Jacoby, E, Fung, A, Adhikary, S, Bhaumik, A, Carbajo, R.J, Bruyn, S.D, Miller, R, Patrick, A, Pham, Q, Piassek, M, Verheyen, N, Shareef, A, Sutto-Ortiz, P, Ysebaert, N, Vlijmen, H.V, Jonckers, T.H.M, Herschke, F, McLellan, J.S, Decroly, E, Fearns, R, Grosse, S, Roymans, D, Sharma, S, Rigaux, P, Jin, Z. | 登録日 | 2023-01-16 | 公開日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor. Commun Biol, 6, 2023
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6U7K
| Prefusion structure of PEDV spike | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Wrapp, D, McLellan, J.S. | 登録日 | 2019-09-03 | 公開日 | 2019-09-18 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | 主引用文献 | The 3.1-Angstrom Cryo-electron Microscopy Structure of the Porcine Epidemic Diarrhea Virus Spike Protein in the Prefusion Conformation. J.Virol., 93, 2019
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7M30
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4DQO
| Crystal Structure of PG16 Fab in Complex with V1V2 Region from HIV-1 strain ZM109 | 分子名称: | 1FD6-V1V2 scaffold ZM109 HIV-1 strain, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PG16 Fab Heavy Chain, ... | 著者 | Pancera, M, McLellan, J.S, Kwong, P.D. | 登録日 | 2012-02-16 | 公開日 | 2013-03-06 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.438 Å) | 主引用文献 | Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16. Nat.Struct.Mol.Biol., 20, 2013
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5L1X
| Structure of the Human Metapneumovirus Fusion Protein in the Postfusion Conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Mas, V, Melero, J.A, McLellan, J.S. | 登録日 | 2016-07-29 | 公開日 | 2016-08-24 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Engineering, Structure and Immunogenicity of the Human Metapneumovirus F Protein in the Postfusion Conformation. Plos Pathog., 12, 2016
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6XKL
| SARS-CoV-2 HexaPro S One RBD up | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Wrapp, D, Hsieh, C.-L, Goldsmith, J.A, McLellan, J.S. | 登録日 | 2020-06-26 | 公開日 | 2020-07-15 | 最終更新日 | 2020-09-30 | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | 主引用文献 | Structure-based design of prefusion-stabilized SARS-CoV-2 spikes. Science, 369, 2020
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7S3N
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7SEJ
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7SEM
| Structure-based design of prefusion-stabilized human metapneumovirus fusion proteins | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, MPE8 Fab heavy chain, ... | 著者 | Rush, S.A, Hsieh, C.-L, McLellan, J.S. | 登録日 | 2021-09-30 | 公開日 | 2022-02-16 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure-based design of prefusion-stabilized human metapneumovirus fusion proteins. Nat Commun, 13, 2022
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7SJ0
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1YHL
| Structure of the complex of Trypanosoma cruzi farnesyl diphosphate synthase with risedronate, dmapp and mg+2 | 分子名称: | 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, DIMETHYLALLYL DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Gabelli, S.B, McLellan, J.S, Montalvetti, A, Oldfield, E, Docampo, R, Amzel, L.M. | 登録日 | 2005-01-09 | 公開日 | 2005-12-20 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: Implications for drug design. Proteins, 62, 2005
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1YHK
| Trypanosoma cruzi farnesyl diphosphate synthase | 分子名称: | SULFATE ION, farnesyl pyrophosphate synthase | 著者 | Gabelli, S.B, McLellan, J.S, Montalvetti, A, Oldfield, E, Docampo, R, Amzel, L.M. | 登録日 | 2005-01-09 | 公開日 | 2005-12-20 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: Implications for drug design. Proteins, 62, 2005
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1YHM
| Structure of the complex of Trypanosoma cruzi farnesyl disphosphate synthase with alendronate, Isopentenyl diphosphate and mg+2 | 分子名称: | 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, 4-AMINO-1-HYDROXYBUTANE-1,1-DIYLDIPHOSPHONATE, MAGNESIUM ION, ... | 著者 | Gabelli, S.B, McLellan, J.S, Montalvetti, A, Oldfield, E, Docampo, R, Amzel, L.M. | 登録日 | 2005-01-09 | 公開日 | 2005-12-20 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: Implications for drug design. Proteins, 62, 2005
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8CW9
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8DF1
| Chi3l1 bound by antibody C59 | 分子名称: | C59 Fab Heavy chain, C59 Fab Light chain, Chitinase-3-like protein 1, ... | 著者 | Wrapp, D, McLellan, J.S. | 登録日 | 2022-06-21 | 公開日 | 2023-03-01 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | A novel humanized Chi3l1 blocking antibody attenuates acetaminophen-induced liver injury in mice. Antib Ther, 6, 2023
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8DCN
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8DCM
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8DMJ
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