7KQD

Prefusion RSV F Bound to RV521

Summary for 7KQD

• Entry DOI: 10.2210/pdb7kqd/pdb
• Descriptor: Fusion glycoprotein F0, 1'-{[5-(aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-benzimidazol-2-yl]methyl}-6'-fluorospiro[cyclopropane-1,3'-indol]-2'(1'H)-one, SULFATE ION (3 entities in total)
• Functional Keywords: ds-cav1, rsv f, inhibitor, viral protein
• Biological source: Respiratory syncytial virus
• Total number of polymer chains: 1
• Total formula weight: 64241.16

Authors

McLellan, J.S. (deposition date: 2020-11-14, release date: 2021-04-21, Last modification date: 2023-10-18)

• Primary citation: Cockerill, G.S.,Angell, R.M.,Bedernjak, A.,Chuckowree, I.,Fraser, I.,Gascon-Simorte, J.,Gilman, M.S.A.,Good, J.A.D.,Harland, R.,Johnson, S.M.,Ludes-Meyers, J.H.,Littler, E.,Lumley, J.,Lunn, G.,Mathews, N.,McLellan, J.S.,Paradowski, M.,Peeples, M.E.,Scott, C.,Tait, D.,Taylor, G.,Thom, M.,Thomas, E.,Villalonga Barber, C.,Ward, S.E.,Watterson, D.,Williams, G.,Young, P.,Powell, K.; Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion.; J.Med.Chem., 64:3658-3676, 2021; PubMed: 33729773; DOI: 10.1021/acs.jmedchem.0c01882

Experimental method

X-RAY DIFFRACTION (2.94 Å)