5FRM
| Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ384 (compound 4a) | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-azanylidene-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-1,8-naphthyridine-3-carboxamide, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP *TP*CP*GP*CP*A)-3', ... | 著者 | Maskell, D.P, Pye, V.E, Cherepanov, P. | 登録日 | 2015-12-18 | 公開日 | 2016-02-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases. Acs Chem.Biol., 11, 2016
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5FRO
| Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ446 (compound 4f) | 分子名称: | 4-azanyl-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-6-[2-(phenylsulfonyl)ethyl]-1,8-naphthyridine-3-carboxamide, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP *TP*CP*GP*CP*A)-3', 5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP *AP*CP*A)-3', ... | 著者 | Maskell, D.P, Pye, V.E, Cherepanov, P. | 登録日 | 2015-12-18 | 公開日 | 2016-02-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | 主引用文献 | HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases. Acs Chem.Biol., 11, 2016
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5FRN
| Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ419 (compound 4c) | 分子名称: | 4-azanyl-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-6-(5-oxidanylpentyl)-1,8-naphthyridine-3-carboxamide, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP *TP*CP*GP*CP*A)-3', 5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP *AP*CP*A)-3', ... | 著者 | Maskell, D.P, Pye, V.E, Cherepanov, P. | 登録日 | 2015-12-18 | 公開日 | 2016-02-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases. Acs Chem.Biol., 11, 2016
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5MMB
| Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ434 (compound 6p) | 分子名称: | DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), GLYCEROL, ... | 著者 | Maskell, D.P, Pye, V.E, Cherepanov, P. | 登録日 | 2016-12-09 | 公開日 | 2017-08-02 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | 主引用文献 | Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors. J. Med. Chem., 60, 2017
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5MMA
| Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ379 (compound 5'g) | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), ... | 著者 | Maskell, D.P, Pye, V.E, Cherepanov, P. | 登録日 | 2016-12-09 | 公開日 | 2017-08-02 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors. J. Med. Chem., 60, 2017
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7ZPP
| Cryo-EM structure of the MVV CSC intasome at 4.5A resolution | 分子名称: | Integrase, vDNA, non-transferred strand, ... | 著者 | Ballandras-Colas, A, Maskell, D, Pye, V.E, Locke, J, Swuec, S, Kotecha, A, Costa, A, Cherepanov, P. | 登録日 | 2022-04-28 | 公開日 | 2022-05-11 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | A supramolecular assembly mediates lentiviral DNA integration Science, 355, 2017
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6RNY
| PFV intasome - nucleosome strand transfer complex | 分子名称: | DNA (108-MER), DNA (128-MER), DNA (33-MER), ... | 著者 | Pye, V.E, Renault, L, Maskell, D.P, Cherepanov, P, Costa, A. | 登録日 | 2019-05-09 | 公開日 | 2019-09-25 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer. Nat Commun, 10, 2019
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8CBW
| CryoEM structure of the Hendra henipavirus nucleocapsid sauronoid assembly monomer | 分子名称: | Nucleocapsid, RNA (5'-R(P*UP*UP*UP*UP*UP*U)-3') | 著者 | Passchier, T.C, Maskell, D.P, Edwards, T.A, Barr, J.N. | 登録日 | 2023-01-26 | 公開日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.485 Å) | 主引用文献 | The cryoEM structure of the Hendra henipavirus nucleoprotein reveals insights into paramyxoviral nucleocapsid architectures. Sci Rep, 14, 2024
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8C4H
| CryoEM structure of the Hendra henipavirus nucleocapsid sauronoid assembly multimer | 分子名称: | Nucleocapsid, RNA (84-MER) | 著者 | Passchier, T.C, Maskell, D.P, Edwards, T.A, Barr, J.N. | 登録日 | 2023-01-04 | 公開日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.485 Å) | 主引用文献 | The cryoEM structure of the Hendra henipavirus nucleoprotein reveals insights into paramyxoviral nucleocapsid architectures. Sci Rep, 14, 2024
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6YRF
| Vip3Bc1 tetramer | 分子名称: | Vegetative insecticidal protein | 著者 | Thompson, R.F, Byrne, M.J, Iadanza, M.I, Arribas Perez, M, Maskell, D.P, George, R.M, Hesketh, E.L, Beales, P.A, Zack, M.D, Berry, C. | 登録日 | 2020-04-20 | 公開日 | 2021-03-17 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Cryo-EM structures of an insecticidal Bt toxin reveal its mechanism of action on the membrane. Nat Commun, 12, 2021
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5M0R
| Cryo-EM reconstruction of the maedi-visna virus (MVV) strand transfer complex | 分子名称: | integrase, tDNA, vDNA, ... | 著者 | Pye, V.E, Ballandras-Colas, A, Maskell, D, Locke, J, Kotecha, A, Costa, A, Cherepanov, P. | 登録日 | 2016-10-05 | 公開日 | 2017-01-18 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (8.2 Å) | 主引用文献 | A supramolecular assembly mediates lentiviral DNA integration. Science, 355, 2017
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1NXM
| The high resolution structures of RmlC from Streptococcus suis | 分子名称: | dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase | 著者 | Dong, C, Major, L.L, Allen, A, Blankenfeldt, W, Maskell, D, Naismith, J.H. | 登録日 | 2003-02-11 | 公開日 | 2003-06-24 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | High-Resolution Structures of RmlC from Streptococcus suis in Complex with Substrate Analogs Locate the Active Site of This Class of Enzyme Structure, 11, 2003
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1NYW
| The high resolution structures of RmlC from Streptoccus suis in complex with dTDP-D-glucose | 分子名称: | 2'DEOXY-THYMIDINE-5'-DIPHOSPHO-ALPHA-D-GLUCOSE, dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase | 著者 | Dong, C, Major, L.L, Allen, A, Blankenfeldt, W, Maskell, D, Naismith, J.H. | 登録日 | 2003-02-14 | 公開日 | 2003-06-24 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | High-Resolution Structures of RmlC from Streptococcus suis in Complex with Substrate Analogs Locate the Active Site of This Class of Enzyme Structure, 11, 2003
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1NZC
| The high resolution structures of RmlC from Streptococcus suis in complex with dTDP-D-xylose | 分子名称: | NICKEL (II) ION, THYMIDINE-5'-DIPHOSPHO-BETA-D-XYLOSE, dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase | 著者 | Dong, C, Major, L.L, Allen, A, Blankenfeldt, W, Maskell, D, Naismith, J.H. | 登録日 | 2003-02-17 | 公開日 | 2003-06-24 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | High-Resolution Structures of RmlC from Streptococcus suis in Complex with Substrate Analogs Locate the Active Site of This Class of Enzyme Structure, 11, 2003
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5LLJ
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2Q1S
| Crystal structure of the Bordetella bronchiseptica enzyme WbmF in complex with NADH | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Putative nucleotide sugar epimerase/ dehydratase | 著者 | Harmer, N.J, King, J.D, Palmer, C.M, Maskell, D, Blundell, T.L. | 登録日 | 2007-05-25 | 公開日 | 2007-10-02 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Predicting protein function from structure--the roles of short-chain dehydrogenase/reductase enzymes in Bordetella O-antigen biosynthesis. J.Mol.Biol., 374, 2007
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2Q1T
| Crystal structure of the Bordetella bronchiseptica enzyme WbmF in complex with NAD+ and UDP | 分子名称: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Putative nucleotide sugar epimerase/ dehydratase, URIDINE-5'-DIPHOSPHATE | 著者 | Harmer, N.J, King, J.D, Palmer, C.M, Maskell, D, Blundell, T.L. | 登録日 | 2007-05-25 | 公開日 | 2007-10-02 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Predicting protein function from structure--the roles of short-chain dehydrogenase/reductase enzymes in Bordetella O-antigen biosynthesis. J.Mol.Biol., 374, 2007
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2PZJ
| Crystal structure of the Bordetella bronchiseptica enzyme WbmF in complex with NAD+ | 分子名称: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Putative nucleotide sugar epimerase/ dehydratase | 著者 | Harmer, N.J, King, J.D, Palmer, C.M, Maskell, D, Blundell, T.L. | 登録日 | 2007-05-18 | 公開日 | 2007-10-02 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Predicting protein function from structure--the roles of short-chain dehydrogenase/reductase enzymes in Bordetella O-antigen biosynthesis. J.Mol.Biol., 374, 2007
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2Q1U
| Crystal structure of the Bordetella bronchiseptica enzyme WbmF in complex with NAD+ and UDP | 分子名称: | GLYCEROL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Putative nucleotide sugar epimerase/ dehydratase, ... | 著者 | Harmer, N.J, King, J.D, Palmer, C.M, Maskell, D, Blundell, T.L. | 登録日 | 2007-05-25 | 公開日 | 2007-10-02 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Predicting protein function from structure--the roles of short-chain dehydrogenase/reductase enzymes in Bordetella O-antigen biosynthesis. J.Mol.Biol., 374, 2007
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2PZM
| Crystal structure of the Bordetella bronchiseptica enzyme WbmG in complex with NAD and UDP | 分子名称: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Putative nucleotide sugar epimerase/ dehydratase, SULFATE ION, ... | 著者 | Harmer, N.J, King, J.D, Palmer, C.M, Maskell, D, Blundell, T.L. | 登録日 | 2007-05-18 | 公開日 | 2007-10-02 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Predicting protein function from structure--the roles of short-chain dehydrogenase/reductase enzymes in Bordetella O-antigen biosynthesis. J.Mol.Biol., 374, 2007
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5MLU
| Crystal structure of the PFV GAG CBS bound to a mononucleosome | 分子名称: | DNA (145-MER), Histone H2A type 1, Histone H2B, ... | 著者 | Pye, V.E, Maskell, D.P, Lesbats, P, Cherepanov, P. | 登録日 | 2016-12-07 | 公開日 | 2017-05-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis for spumavirus GAG tethering to chromatin. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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2Q1W
| Crystal structure of the Bordetella bronchiseptica enzyme WbmH in complex with NAD+ | 分子名称: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Putative nucleotide sugar epimerase/ dehydratase | 著者 | King, J.D, Harmer, N.J, Maskell, D.J, Blundell, T.L. | 登録日 | 2007-05-25 | 公開日 | 2007-10-02 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Predicting protein function from structure--the roles of short-chain dehydrogenase/reductase enzymes in Bordetella O-antigen biosynthesis. J.Mol.Biol., 374, 2007
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2PZK
| Crystal structure of the Bordetella bronchiseptica enzyme WbmG in complex with NAD | 分子名称: | MAGNESIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Putative nucleotide sugar epimerase/ dehydratase | 著者 | King, J.D, Harmer, N.J, Maskell, D.J, Blundell, T.L. | 登録日 | 2007-05-18 | 公開日 | 2007-10-02 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Predicting protein function from structure--the roles of short-chain dehydrogenase/reductase enzymes in Bordetella O-antigen biosynthesis. J.Mol.Biol., 374, 2007
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2PZL
| Crystal structure of the Bordetella bronchiseptica enzyme WbmG in complex with NAD and UDP | 分子名称: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Putative nucleotide sugar epimerase/ dehydratase, URIDINE-5'-DIPHOSPHATE | 著者 | King, J.D, Harmer, N.J, Maskell, D.J, Blundell, T.L. | 登録日 | 2007-05-18 | 公開日 | 2007-10-02 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Predicting protein function from structure--the roles of short-chain dehydrogenase/reductase enzymes in Bordetella O-antigen biosynthesis. J.Mol.Biol., 374, 2007
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