Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 93 件
7F9D
DownloadVisualize
BU of 7f9d by Molmil
Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L96
分子名称: 4-[(3S)-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(5-methoxypyridin-3-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, CALCIUM ION, ...
著者Manickam, Y, Malhotra, N, Sharma, A.
登録日2021-07-04
公開日2022-10-05
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.497 Å)
主引用文献Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
7F9B
DownloadVisualize
BU of 7f9b by Molmil
Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L95
分子名称: Bifunctional glutamate/proline--tRNA ligase, CALCIUM ION, CHLORIDE ION, ...
著者Manickam, Y, Malhotra, N, Sharma, A.
登録日2021-07-04
公開日2022-10-05
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.995 Å)
主引用文献Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
7F99
DownloadVisualize
BU of 7f99 by Molmil
Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L96
分子名称: 4-[(3S)-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(5-methoxypyridin-3-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, CALCIUM ION, ...
著者Manickam, Y, Malhotra, N, Sharma, A.
登録日2021-07-04
公開日2022-07-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.979 Å)
主引用文献Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
5Z79
DownloadVisualize
BU of 5z79 by Molmil
Crystal Structure Analysis of the HPPK-DHPS in complex with substrates
分子名称: 4-AMINOBENZOIC ACID, 5'-DEOXYADENOSINE, 6-HYDROXYMETHYLPTERIN-DIPHOSPHATE, ...
著者Manickam, Y, Karl, H, Sharma, A.
登録日2018-01-27
公開日2018-08-29
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase fromPlasmodium vivaxsheds light on drug resistance
J. Biol. Chem., 293, 2018
4LMZ
DownloadVisualize
BU of 4lmz by Molmil
Structural insight into RNA recognition by RRM1+2 domain of human ETR-3 protein
分子名称: CUGBP Elav-like family member 2, RNA (5'-R(*GP*CP*UP*GP*CP*GP*UP*AP*UP*UP*GP*UP*UP*UP*G)-3')
著者Bhatt, H, Manickam, Y, Bhavesh, N.S.
登録日2013-07-11
公開日2014-07-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.78 Å)
主引用文献sequence specific RNA recognition of ETR3 RRM 1-2 domains
TO BE PUBLISHED
6M0T
DownloadVisualize
BU of 6m0t by Molmil
Crystal Structure of Lysyl-tRNA Synthetase from Plasmodium falciparum complexed with L-lysine and Cladosporin derivative (CL-2)
分子名称: (3R)-3-[(R)-[(2R,6S)-6-methyloxan-2-yl]-oxidanyl-methyl]-6,8-bis(oxidanyl)-3,4-dihydroisochromen-1-one, LYSINE, Lysine--tRNA ligase
著者Babbar, P, Sharma, A, Manickam, Y.
登録日2020-02-22
公開日2021-04-21
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Design, Synthesis, and Structural Analysis of Cladosporin-Based Inhibitors of Malaria Parasites.
Acs Infect Dis., 7, 2021
5XIP
DownloadVisualize
BU of 5xip by Molmil
Crystal Structure of Eimeria tenella Prolyl-tRNA Synthetase (EtPRS) in complex with Halofuginone
分子名称: 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Jain, V, Manickam, Y, Sharma, A.
登録日2017-04-26
公開日2018-03-07
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIK
DownloadVisualize
BU of 5xik by Molmil
Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with tetrahydro quinazolinone febrifugine
分子名称: 3-[2-oxidanylidene-3-[(2R,3R)-3-oxidanylpiperidin-2-yl]propyl]-5,6,7,8-tetrahydroquinazolin-4-one, CHLORIDE ION, MAGNESIUM ION, ...
著者Jain, V, Manickam, Y, Sharma, A.
登録日2017-04-26
公開日2018-03-07
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIJ
DownloadVisualize
BU of 5xij by Molmil
Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with Inhibitor 9
分子名称: 3-[(2R)-2-oxidanyl-3-[(2R,3R)-3-oxidanylpiperidin-2-yl]propyl]quinazolin-4-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Jain, V, Manickam, Y, Sharma, A.
登録日2017-04-26
公開日2018-03-07
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIH
DownloadVisualize
BU of 5xih by Molmil
Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with inhibitor 5
分子名称: 6,7-bis(fluoranyl)-3-[3-[(2R)-3-oxidanylidenepiperidin-2-yl]propyl]quinazolin-4-one, CHLORIDE ION, MAGNESIUM ION, ...
著者Jain, V, Manickam, Y, Sharma, A.
登録日2017-04-26
公開日2018-03-07
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIO
DownloadVisualize
BU of 5xio by Molmil
Crystal Structure of Cryptosporidium parvum Prolyl-tRNA Synthetase (CpPRS) in complex with Halofuginone
分子名称: 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Proline-tRNA synthetase class II aaRS (Ybak RNA binding domain plus tRNA synthetase), ...
著者Jain, V, Manickam, Y, Sharma, A.
登録日2017-04-26
公開日2018-03-07
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5JLD
DownloadVisualize
BU of 5jld by Molmil
Crystal Structure of Arginyl-tRNA Synthetase from Plasmodium falciparum (PfRRS)
分子名称: Arginyl-tRNA synthetase, putative
著者Jain, V, Manickam, Y, Sharma, A.
登録日2016-04-27
公開日2016-08-24
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Dimerization of Arginyl-tRNA Synthetase by Free Heme Drives Its Inactivation in Plasmodium falciparum
Structure, 24, 2016
6L4Q
DownloadVisualize
BU of 6l4q by Molmil
Crystal Structure of Lysyl-tRNA Synthetase from Plasmodium falciparum complexed with L-lysine and Clado-B
分子名称: (3R)-3-[[(3R)-3-methylpiperidin-1-yl]methyl]-6,8-bis(oxidanyl)-3,4-dihydroisochromen-1-one, LYSINE, Lysine--tRNA ligase
著者Babbar, P, Sharma, A, Manickam, Y, Mishra, S, Harlos, K.
登録日2019-10-19
公開日2021-05-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Crystal Structure of Lysyl-tRNA Synthetase from Plasmodium falciparum complexed with L-lysine and Cladosporin inhibitor, Cla-B
Chembiochem, 2021
6L3Y
DownloadVisualize
BU of 6l3y by Molmil
Crystal Structure of Lysyl-tRNA Synthetase from Plasmodium falciparum complexed with L-lysine and Clado-C
分子名称: (3R)-3-[[(3S)-3-ethylpiperidin-1-yl]methyl]-6,8-bis(oxidanyl)-3,4-dihydroisochromen-1-one, LYSINE, Lysine--tRNA ligase, ...
著者Babbar, P, Sharma, A, Mishra, S, Manickam, Y, Harlos, K.
登録日2019-10-15
公開日2021-05-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Crystal Structure of Lysyl-tRNA Synthetase from Plasmodium falciparum complexed with L-lysine and Cladosporin inhibitor, Cla-B
Chembiochem, 2021
7EVU
DownloadVisualize
BU of 7evu by Molmil
Co-crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in complex with HFG and JE6
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, Prolyl-tRNA synthetase (ProRS), ...
著者Mishra, S, Malhotra, N, Manickam, Y, Sharma, A.
登録日2021-05-22
公開日2022-03-09
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.697 Å)
主引用文献Double drugging of prolyl-tRNA synthetase provides a new paradigm for anti-infective drug development.
Plos Pathog., 18, 2022
7EVV
DownloadVisualize
BU of 7evv by Molmil
Co-crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in complex with JE6 and L-pro
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, PROLINE, ...
著者Malhotra, N, Mishra, S, Manickam, Y, Sharma, A.
登録日2021-05-22
公開日2022-03-09
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.704 Å)
主引用文献Double drugging of prolyl-tRNA synthetase provides a new paradigm for anti-infective drug development.
Plos Pathog., 18, 2022
7F9T
DownloadVisualize
BU of 7f9t by Molmil
Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in Complex with inhibitor L97 and Halofuginone
分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-[(3S)-3-cyclopropyl-3-(hydroxymethyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, ...
著者Malhotra, N, Manickam, Y, Sharma, A.
登録日2021-07-04
公開日2022-10-05
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.489 Å)
主引用文献TgPRS with double inhibitors
To Be Published
5ZG8
DownloadVisualize
BU of 5zg8 by Molmil
Crystal Structure of TtNRS
分子名称: Asparagine--tRNA ligase
著者Mutharasappan, N, Jain, V, Sharma, A, Manickam, Y, Jeyaraman, J.
登録日2018-03-08
公開日2019-03-13
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal Structure of TtNRS
To be published
5XIF
DownloadVisualize
BU of 5xif by Molmil
Crystal Structure of Prolyl-tRNA Synthetase (PRS) from Toxoplasma gondii
分子名称: CHLORIDE ION, Prolyl-tRNA synthetase (ProRS)
著者Jain, V, Manickam, Y, Sharma, A.
登録日2017-04-26
公開日2018-03-07
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIQ
DownloadVisualize
BU of 5xiq by Molmil
Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with Halofuginone
分子名称: 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Jain, V, Manickam, Y, Sharma, A.
登録日2017-04-26
公開日2018-03-07
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XII
DownloadVisualize
BU of 5xii by Molmil
Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with inhibitor 6
分子名称: 1,2-ETHANEDIOL, 6-chloranyl-7-fluoranyl-3-[3-[(2R)-3-oxidanylidenepiperidin-2-yl]propyl]quinazolin-4-one, CHLORIDE ION, ...
著者Jain, V, Manickam, Y, Sharma, A.
登録日2017-04-26
公開日2018-03-07
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.17 Å)
主引用文献Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIL
DownloadVisualize
BU of 5xil by Molmil
Crystal Structure of Leishmania major Prolyl-tRNA Synthetase (LmPRS)
分子名称: ACETATE ION, MAGNESIUM ION, Putative prolyl-tRNA synthetase, ...
著者Jain, V, Manickam, Y, Sharma, A.
登録日2017-04-26
公開日2018-03-07
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIG
DownloadVisualize
BU of 5xig by Molmil
Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with Inhibitor 1
分子名称: 3-[3-[(2R)-3-oxidanylidenepiperidin-2-yl]propyl]quinazolin-4-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Jain, V, Manickam, Y, Sharma, A.
登録日2017-04-26
公開日2018-03-07
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
4JFA
DownloadVisualize
BU of 4jfa by Molmil
Crystal Structure of Plasmodium falciparum Tryptophanyl-tRNA synthetase
分子名称: BETA-MERCAPTOETHANOL, POTASSIUM ION, TRYPTOPHAN, ...
著者Khan, S, Garg, A, Manickam, Y, Sharma, A.
登録日2013-02-28
公開日2014-01-29
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献An appended domain results in an unusual architecture for malaria parasite tryptophanyl-tRNA synthetase
Plos One, 8, 2013
7DPI
DownloadVisualize
BU of 7dpi by Molmil
Plasmodium falciparum cytoplasmic Phenylalanyl-tRNA synthetase in complex with BRD7929
分子名称: (8R,9S,10S)-10-[(dimethylamino)methyl]-N-(4-methoxyphenyl)-9-[4-(2-phenylethynyl)phenyl]-1,6-diazabicyclo[6.2.0]decane-6-carboxamide, MAGNESIUM ION, Phenylalanine--tRNA ligase, ...
著者Manmohan, S, Malhotra, N, Harlos, K, Manickam, Y, Sharma, A.
登録日2020-12-19
公開日2022-03-23
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (3.597 Å)
主引用文献Inhibition of Plasmodium falciparum phenylalanine tRNA synthetase provides opportunity for antimalarial drug development.
Structure, 30, 2022

223532

件を2024-08-07に公開中

PDB statisticsPDBj update infoContact PDBjnumon