7DPI
Plasmodium falciparum cytoplasmic Phenylalanyl-tRNA synthetase in complex with BRD7929
Summary for 7DPI
Entry DOI | 10.2210/pdb7dpi/pdb |
Descriptor | Phenylalanine--tRNA ligase, Phenylalanyl-tRNA synthetase beta subunit, (8R,9S,10S)-10-[(dimethylamino)methyl]-N-(4-methoxyphenyl)-9-[4-(2-phenylethynyl)phenyl]-1,6-diazabicyclo[6.2.0]decane-6-carboxamide, ... (4 entities in total) |
Functional Keywords | aminoacylation, aminoacyl-trna synthetase, trna-binding, atp-binding, auxiliary pocket, heterotetrameric, ligase |
Biological source | Plasmodium falciparum More |
Total number of polymer chains | 4 |
Total formula weight | 219180.68 |
Authors | Manmohan, S.,Malhotra, N.,Harlos, K.,Manickam, Y.,Sharma, A. (deposition date: 2020-12-19, release date: 2022-03-23, Last modification date: 2024-05-29) |
Primary citation | Sharma, M.,Mutharasappan, N.,Manickam, Y.,Harlos, K.,Melillo, B.,Comer, E.,Tabassum, H.,Parvez, S.,Schreiber, S.L.,Sharma, A. Inhibition of Plasmodium falciparum phenylalanine tRNA synthetase provides opportunity for antimalarial drug development. Structure, 30:962-972.e3, 2022 Cited by PubMed: 35460612DOI: 10.1016/j.str.2022.03.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.597 Å) |
Structure validation
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