3ZLS
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![BU of 3zls by Molmil](/molmil-images/mine/3zls) | Crystal structure of MEK1 in complex with fragment 6 | 分子名称: | 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID, DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1, SODIUM ION | 著者 | Amaning, K, Lowinsky, M, Vallee, F, Steier, V, Marcireau, C, Ugolini, A, Delorme, C, McCort, G, Andouche, C, Vougier, S, Llopart, S, Halland, N, Rak, A. | 登録日 | 2013-02-04 | 公開日 | 2013-05-22 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The Use of Virtual Screening and Differential Scanning Fluorimetry for the Rapid Identification of Fragments Active Against Mek1. Bioorg.Med.Chem.Lett., 23, 2013
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3ZM4
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![BU of 3zm4 by Molmil](/molmil-images/mine/3zm4) | Crystal structure of MEK1 in complex with fragment 1 | 分子名称: | 7-chloranyl-6-[(3S)-pyrrolidin-3-yl]oxy-2H-isoquinolin-1-one, DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 | 著者 | Amaning, K, Lowinsky, M, Vallee, F, Steier, V, Marcireau, C, Ugolini, A, Delorme, C, McCort, G, Andouche, C, Vougier, S, Llopart, S, Halland, N, Rak, A. | 登録日 | 2013-02-05 | 公開日 | 2013-05-22 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | 主引用文献 | The Use of Virtual Screening and Differential Scanning Fluorimetry for the Rapid Identification of Fragments Active Against Mek1. Bioorg.Med.Chem.Lett., 23, 2013
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3ZLY
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![BU of 3zly by Molmil](/molmil-images/mine/3zly) | Crystal structure of MEK1 in complex with fragment 8 | 分子名称: | 3-AMINO-1H-INDAZOLE-4-CARBONITRILE, DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1, SODIUM ION | 著者 | Amaning, K, Lowinsky, M, Vallee, F, Steier, V, Marcireau, C, Ugolini, A, Delorme, C, McCort, G, Andouche, C, Vougier, S, Llopart, S, Halland, N, Rak, A. | 登録日 | 2013-02-04 | 公開日 | 2013-05-22 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | The Use of Virtual Screening and Differential Scanning Fluorimetry for the Rapid Identification of Fragments Active Against Mek1. Bioorg.Med.Chem.Lett., 23, 2013
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6IW3
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3H5J
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![BU of 3h5j by Molmil](/molmil-images/mine/3h5j) | LeuD_1-168 small subunit of isopropylmalate isomerase (Rv2987c) from mycobacterium tuberculosis | 分子名称: | 1,2-ETHANEDIOL, 3-isopropylmalate dehydratase small subunit, SULFATE ION | 著者 | Manikandan, K, Geerlof, A, Weiss, M.S. | 登録日 | 2009-04-22 | 公開日 | 2010-04-07 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Structural studies on the enzyme complex isopropylmalate isomerase (LeuCD) from Mycobacterium tuberculosis Proteins, 79, 2011
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6JCK
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![BU of 6jck by Molmil](/molmil-images/mine/6jck) | Complex structure of Axin-DIX and Dvl2-DIX | 分子名称: | Axin-1, Segment polarity protein dishevelled homolog DVL-2 | 著者 | Yamanishi, K, Shibata, N. | 登録日 | 2019-01-29 | 公開日 | 2020-01-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.09 Å) | 主引用文献 | A direct heterotypic interaction between the DIX domains of Dishevelled and Axin mediates signaling to beta-catenin. Sci.Signal., 12, 2019
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3H5E
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![BU of 3h5e by Molmil](/molmil-images/mine/3h5e) | |
3H5H
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3ZLW
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![BU of 3zlw by Molmil](/molmil-images/mine/3zlw) | Crystal structure of MEK1 in complex with fragment 3 | 分子名称: | (1R)-1-hydroxy-1-methyl-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-5-one, DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 MAPK/ERK KINASE 1, MEK 1, ... | 著者 | Amaning, K, Lowinsky, M, Vallee, F, Steier, V, Marcireau, C, Ugolini, A, Delorme, C, McCort, G, Andouche, C, Vougier, S, Llopart, S, Halland, N, Rak, A. | 登録日 | 2013-02-04 | 公開日 | 2013-05-22 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | The Use of Virtual Screening and Differential Scanning Fluorimetry for the Rapid Identification of Fragments Active Against Mek1. Bioorg.Med.Chem.Lett., 23, 2013
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3ZLX
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![BU of 3zlx by Molmil](/molmil-images/mine/3zlx) | Crystal structure of MEK1 in complex with fragment 18 | 分子名称: | 7-choro-6-[(3R)-pyrrolidin-3-ylmethoxy]isoquinolin-1(2H)-one, DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 | 著者 | Amaning, K, Lowinsky, M, Vallee, F, Steier, V, Marcireau, C, Ugolini, A, Delorme, C, McCort, G, Andouche, C, Vougier, S, Llopart, S, Halland, N, Rak, A. | 登録日 | 2013-02-04 | 公開日 | 2013-05-22 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The Use of Virtual Screening and Differential Scanning Fluorimetry for the Rapid Identification of Fragments Active Against Mek1. Bioorg.Med.Chem.Lett., 23, 2013
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7AU2
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![BU of 7au2 by Molmil](/molmil-images/mine/7au2) | Cryo-EM structure of human exostosin-like 3 (EXTL3) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Exostosin-like 3, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Wilson, L.F.L, Dendooven, T, Hardwick, S.W, Chirgadze, D.Y, Luisi, B.F, Logan, D.T, Mani, K, Dupree, P. | 登録日 | 2020-11-02 | 公開日 | 2022-05-18 | 最終更新日 | 2022-06-15 | 実験手法 | ELECTRON MICROSCOPY (2.43 Å) | 主引用文献 | The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis. Nat Commun, 13, 2022
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7AUA
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![BU of 7aua by Molmil](/molmil-images/mine/7aua) | Cryo-EM structure of human exostosin-like 3 (EXTL3) in complex with UDP | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Exostosin-like 3, MANGANESE (II) ION, ... | 著者 | Wilson, L.F.L, Dendooven, T, Hardwick, S.W, Chirgadze, D.Y, Luisi, B.F, Logan, D.T, Mani, K, Dupree, P. | 登録日 | 2020-11-02 | 公開日 | 2022-05-18 | 最終更新日 | 2022-06-15 | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | 主引用文献 | The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis. Nat Commun, 13, 2022
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4YWT
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4BWE
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![BU of 4bwe by Molmil](/molmil-images/mine/4bwe) | Crystal structure of C-terminally truncated glypican-1 after controlled dehydration to 86 percent relative humidity | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Glypican-1 | 著者 | Awad, W, Svensson Birkedal, G, Thunnissen, M.M.G.M, Mani, K, Logan, D.T. | 登録日 | 2013-07-01 | 公開日 | 2013-12-18 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | Improvements in the order, isotropy and electron density of glypican-1 crystals by controlled dehydration. Acta Crystallogr. D Biol. Crystallogr., 69, 2013
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4AD7
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![BU of 4ad7 by Molmil](/molmil-images/mine/4ad7) | Crystal structure of full-length N-glycosylated human glypican-1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYPICAN-1 | 著者 | Svensson, G, Awad, W, Mani, K, Logan, D.T. | 登録日 | 2011-12-22 | 公開日 | 2012-03-21 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.945 Å) | 主引用文献 | Crystal Structure of N-Glycosylated Human Glypican-1 Core Protein: Structure of Two Loops Evolutionarily Conserved in Vertebrate Glypican-1. J.Biol.Chem., 287, 2012
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4ACR
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![BU of 4acr by Molmil](/molmil-images/mine/4acr) | Crystal structure of N-glycosylated, C-terminally truncated human glypican-1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYPICAN-1 | 著者 | Svensson, G, Awad, W, Mani, K, Logan, D.T. | 登録日 | 2011-12-17 | 公開日 | 2012-02-22 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Crystal Structure of N-Glycosylated Human Glypican-1 Core Protein: Structure of Two Loops Evolutionarily Conserved in Vertebrate Glypican-1. J.Biol.Chem., 287, 2012
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7PY4
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![BU of 7py4 by Molmil](/molmil-images/mine/7py4) | Cryo-EM structure of ATP8B1-CDC50A in E2P autoinhibited state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BERYLLIUM TRIFLUORIDE ION, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Dieudonne, T, Abad-Herrera, S, Juknaviciute Laursen, M, Lejeune, M, Stock, C, Slimani, K, Jaxel, C, Lyons, J.A, Montigny, C, Gunther Pomorski, T, Nissen, P, Lenoir, G. | 登録日 | 2021-10-08 | 公開日 | 2022-04-27 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Autoinhibition and regulation by phosphoinositides of ATP8B1, a human lipid flippase associated with intrahepatic cholestatic disorders. Elife, 11, 2022
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2I6Y
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![BU of 2i6y by Molmil](/molmil-images/mine/2i6y) | Structure and Mechanism of Mycobacterium tuberculosis Salicylate Synthase, MbtI | 分子名称: | Anthranilate synthase component I, putative | 著者 | Zwahlen, J, Subramaniapillai, K, Zhou, R, Kisker, C, Tonge, P.J. | 登録日 | 2006-08-29 | 公開日 | 2007-06-19 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure and mechanism of MbtI, the salicylate synthase from Mycobacterium tuberculosis Biochemistry, 46, 2007
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2Y42
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![BU of 2y42 by Molmil](/molmil-images/mine/2y42) | Structure of Isopropylmalate dehydrogenase from Thermus thermophilus - complex with NADH and Mn | 分子名称: | 3-ISOPROPYLMALATE DEHYDROGENASE, BICINE, MANGANESE (II) ION, ... | 著者 | Graczer, E, merlin, A, Singh, R.K, Manikandan, K, Zavodsky, P, Weiss, M.S, Vas, M. | 登録日 | 2011-01-04 | 公開日 | 2011-01-19 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Atomic Level Description of the Domain Closure in a Dimeric Enzyme: Thermus Thermophilus 3-Isopropylmalate Dehydrogenase. Mol.Biosyst., 7, 2011
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1RKU
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![BU of 1rku by Molmil](/molmil-images/mine/1rku) | Crystal Structure of ThrH gene product of Pseudomonas Aeruginosa | 分子名称: | 1,2-ETHANEDIOL, MAGNESIUM ION, homoserine kinase | 著者 | Singh, S.K, Yang, K, Subramanian, K, Karthikeyan, S, Huynh, T, Zhang, X, Phillips, M.A, Zhang, H. | 登録日 | 2003-11-23 | 公開日 | 2004-03-30 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | The thrH Gene Product of Pseudomonas aeruginosa Is a Dual Activity Enzyme with a Novel Phosphoserine:Homoserine Phosphotransferase Activity. J.Biol.Chem., 279, 2004
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2FGL
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![BU of 2fgl by Molmil](/molmil-images/mine/2fgl) | An alkali thermostable F/10 xylanase from alkalophilic Bacillus sp. NG-27 | 分子名称: | MAGNESIUM ION, alkaline thermostable endoxylanase, alpha-D-xylopyranose, ... | 著者 | Ramakumar, S, Manikandan, K, Bhardwaj, A, Reddy, V.S, Lokanath, N.K, Ghosh, A. | 登録日 | 2005-12-22 | 公開日 | 2006-09-26 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structures of native and xylosaccharide-bound alkali thermostable xylanase from an alkalophilic Bacillus sp. NG-27: structural insights into alkalophilicity and implications for adaptation to polyextreme conditions. Protein Sci., 15, 2006
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1RKV
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![BU of 1rkv by Molmil](/molmil-images/mine/1rkv) | Structure of Phosphate complex of ThrH from Pseudomonas aeruginosa | 分子名称: | 1,2-ETHANEDIOL, MAGNESIUM ION, PHOSPHATE ION, ... | 著者 | Singh, S.K, Yang, K, Subramanian, K, Karthikeyan, S, Huynh, T, Zhang, X, Phillips, M.A, Zhang, H. | 登録日 | 2003-11-23 | 公開日 | 2004-03-30 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The thrH Gene Product of Pseudomonas aeruginosa Is a Dual Activity Enzyme with a Novel Phosphoserine:Homoserine Phosphotransferase Activity. J.Biol.Chem., 279, 2004
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2Y41
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![BU of 2y41 by Molmil](/molmil-images/mine/2y41) | Structure of Isopropylmalate dehydrogenase from Thermus thermophilus - complex with IPM and MN | 分子名称: | 3-ISOPROPYLMALATE DEHYDROGENASE, 3-ISOPROPYLMALIC ACID, MANGANESE (II) ION | 著者 | Graczer, E, merlin, A, Singh, R.K, Manikandan, K, Zavodsky, P, Weiss, M.S, Vas, M. | 登録日 | 2011-01-04 | 公開日 | 2011-01-19 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Atomic Level Description of the Domain Closure in a Dimeric Enzyme: Thermus Thermophilus 3-Isopropylmalate Dehydrogenase. Mol.Biosyst., 7, 2011
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2Y40
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![BU of 2y40 by Molmil](/molmil-images/mine/2y40) | Structure of Isopropylmalate dehydrogenase from Thermus thermophilus - complex with Mn | 分子名称: | 3-ISOPROPYLMALATE DEHYDROGENASE, MANGANESE (II) ION | 著者 | Graczer, E, merlin, A, Singh, R.K, Manikandan, K, Zavodsky, P, Weiss, M.S, Vas, M. | 登録日 | 2011-01-04 | 公開日 | 2011-01-19 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Atomic Level Description of the Domain Closure in a Dimeric Enzyme: Thermus Thermophilus 3-Isopropylmalate Dehydrogenase. Mol.Biosyst., 7, 2011
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2Y3Z
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![BU of 2y3z by Molmil](/molmil-images/mine/2y3z) | Structure of Isopropylmalate dehydrogenase from Thermus thermophilus - apo enzyme | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-ISOPROPYLMALATE DEHYDROGENASE, GLYCEROL, ... | 著者 | Graczer, E, merlin, A, Singh, R.K, Manikandan, K, Zavodsky, P, Weiss, M.S, Vas, M. | 登録日 | 2011-01-04 | 公開日 | 2011-01-19 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Atomic Level Description of the Domain Closure in a Dimeric Enzyme: Thermus Thermophilus 3-Isopropylmalate Dehydrogenase. Mol.Biosyst., 7, 2011
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