5U8U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5u8u by Molmil](/molmil-images/mine/5u8u) | Dihydrolipoamide dehydrogenase (LpdG) from Pseudomonas aeruginosa | Descriptor: | DIMETHYL SULFOXIDE, Dihydrolipoyl dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Glasser, N.R, Wang, B.X, Hoy, J.A, Newman, D.K. | Deposit date: | 2016-12-15 | Release date: | 2017-02-15 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | The Pyruvate and alpha-Ketoglutarate Dehydrogenase Complexes of Pseudomonas aeruginosa Catalyze Pyocyanin and Phenazine-1-carboxylic Acid Reduction via the Subunit Dihydrolipoamide Dehydrogenase. J. Biol. Chem., 292, 2017
|
|
5H37
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5h37 by Molmil](/molmil-images/mine/5h37) | Cryo-EM structure of zika virus complexed with Fab C10 at pH 8.0 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C10 IgG heavy chain variable region, C10 IgG light chain variable region, ... | Authors: | Zhang, S, Kostyuchenko, V, Ng, T.-S, Lim, X.-N, Ooi, J.S.G, Lambert, S, Tan, T.Y, Widman, D, Shi, J, Baric, R.S, Lok, S.-M. | Deposit date: | 2016-10-20 | Release date: | 2016-11-30 | Last modified: | 2022-03-23 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Neutralization mechanism of a highly potent antibody against Zika virus Nat Commun, 7, 2016
|
|
7MW0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7mw0 by Molmil](/molmil-images/mine/7mw0) | Crystal structure of Homo sapiens NUP93 solenoid (residues 174-819) | Descriptor: | 1,2-ETHANEDIOL, Nuclear pore complex protein Nup93 | Authors: | Petrovic, S, Samanta, D, Perriches, T, Bley, C.J, Thierbach, K, Brown, B, Nie, S, Mobbs, G.W, Stevens, T.A, Liu, X, Tomaleri, G.P, Schaus, L, Hoelz, A. | Deposit date: | 2021-05-15 | Release date: | 2022-06-15 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Architecture of the linker-scaffold in the nuclear pore. Science, 376, 2022
|
|
5NSD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5nsd by Molmil](/molmil-images/mine/5nsd) | Co-crystal structure of NAMPT dimer with KPT-9274 | Descriptor: | (~{E})-3-(6-azanylpyridin-3-yl)-~{N}-[[5-[4-[4,4-bis(fluoranyl)piperidin-1-yl]carbonylphenyl]-7-(4-fluorophenyl)-1-benzofuran-2-yl]methyl]prop-2-enamide, GLYCEROL, Nicotinamide phosphoribosyltransferase, ... | Authors: | Neggers, J.E, Kwanten, B, Dierckx, T, Noguchi, H, Voet, A, Vercruysse, T, Baloglu, E, Senapedis, W, Jacquemyn, M, Daelemans, D. | Deposit date: | 2017-04-26 | Release date: | 2018-02-14 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.046 Å) | Cite: | Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes. Nat Commun, 9, 2018
|
|
5OHK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ohk by Molmil](/molmil-images/mine/5ohk) | Crystal structure of USP30 in covalent complex with ubiquitin propargylamide (high resolution) | Descriptor: | Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 30,Ubiquitin carboxyl-terminal hydrolase 30,Ubiquitin carboxyl-terminal hydrolase 30, ZINC ION, ... | Authors: | Gersch, M, Komander, D. | Deposit date: | 2017-07-17 | Release date: | 2017-09-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Mechanism and regulation of the Lys6-selective deubiquitinase USP30. Nat. Struct. Mol. Biol., 24, 2017
|
|
5OHP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ohp by Molmil](/molmil-images/mine/5ohp) | |
8UYI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8uyi by Molmil](/molmil-images/mine/8uyi) | Structure of ADP-bound and phosphorylated Pediculus humanus (Ph) PINK1 dimer | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Serine/threonine-protein kinase Pink1, ... | Authors: | Gan, Z.Y, Kirk, N.S, Leis, A, Komander, D. | Deposit date: | 2023-11-13 | Release date: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (3.13 Å) | Cite: | Interaction of PINK1 with nucleotides and kinetin. Sci Adv, 10, 2024
|
|
5OHL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ohl by Molmil](/molmil-images/mine/5ohl) | K6-specific affimer bound to K6 diUb | Descriptor: | GLYCEROL, K6-specific affimer, POLYETHYLENE GLYCOL (N=34), ... | Authors: | Michel, M.A, Komander, D. | Deposit date: | 2017-07-17 | Release date: | 2017-10-04 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling. Mol. Cell, 68, 2017
|
|
5FMV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5fmv by Molmil](/molmil-images/mine/5fmv) | Crystal structure of human CD45 extracellular region, domains d1-d4 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C, SULFATE ION | Authors: | Chang, V.T, Fernandes, R.A, Ganzinger, K.A, Lee, S.F, Siebold, C, McColl, J, Jonsson, P, Palayret, M, Harlos, K, Coles, C.H, Jones, E.Y, Lui, Y, Huang, E, Gilbert, R.J.C, Klenerman, D, Aricescu, A.R, Davis, S.J. | Deposit date: | 2015-11-09 | Release date: | 2016-03-23 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Initiation of T Cell Signaling by Cd45 Segregation at 'Close Contacts'. Nat.Immunol., 17, 2016
|
|
5FN6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5fn6 by Molmil](/molmil-images/mine/5fn6) | Crystal structure of human CD45 extracellular region, domains d1-d3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C | Authors: | Chang, V.T, Fernandes, R.A, Ganzinger, K.A, Lee, S.F, Siebold, C, McColl, J, Jonsson, P, Palayret, M, Harlos, K, Coles, C.H, Jones, E.Y, Lui, Y, Huang, E, Gilbert, R.J.C, Klenerman, D, Aricescu, A.R, Davis, S.J. | Deposit date: | 2015-11-10 | Release date: | 2016-03-23 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Initiation of T Cell Signaling by Cd45 Segregation at 'Close Contacts'. Nat.Immunol., 17, 2016
|
|
6M9T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6m9t by Molmil](/molmil-images/mine/6m9t) | Crystal structure of EP3 receptor bound to misoprostol-FA | Descriptor: | (11alpha,12alpha,13E,16S)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, OLEIC ACID, ... | Authors: | Audet, M, White, K.L, Breton, B, Zarzycka, B, Han, G.W, Lu, Y, Gati, C, Batyuk, A, Popov, P, Velasquez, J, Manahan, D, Hu, H, Weierstall, U, Liu, W, Shui, W, Katrich, V, Cherezov, V, Hanson, M.A, Stevens, R.C. | Deposit date: | 2018-08-24 | Release date: | 2018-12-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of misoprostol bound to the labor inducer prostaglandin E2receptor. Nat. Chem. Biol., 15, 2019
|
|
5OE7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5oe7 by Molmil](/molmil-images/mine/5oe7) | |
2TPK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2tpk by Molmil](/molmil-images/mine/2tpk) | |
4A7H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4a7h by Molmil](/molmil-images/mine/4a7h) | Structure of the Actin-Tropomyosin-Myosin Complex (rigor ATM 2) | Descriptor: | ACTIN, ALPHA SKELETAL MUSCLE, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Behrmann, E, Mueller, M, Penczek, P.A, Mannherz, H.G, Manstein, D.J, Raunser, S. | Deposit date: | 2011-11-14 | Release date: | 2012-08-01 | Last modified: | 2017-08-30 | Method: | ELECTRON MICROSCOPY (7.8 Å) | Cite: | Structure of the Rigor Actin-Tropomyosin-Myosin Complex. Cell(Cambridge,Mass.), 150, 2012
|
|
3ZNZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3znz by Molmil](/molmil-images/mine/3znz) | Crystal structure of OTULIN OTU domain (C129A) in complex with Met1- di ubiquitin | Descriptor: | POLYUBIQUITIN-C, PROTEIN FAM105B, SULFATE ION | Authors: | Keusekotten, K, Elliott, P.R, Glockner, L, Kulathu, Y, Wauer, T, Krappmann, D, Hofmann, K, Komander, D. | Deposit date: | 2013-02-18 | Release date: | 2013-06-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Otulin Antagonizes Lubac Signaling by Specifically Hydrolyzing met1-Linked Polyubiquitin. Cell(Cambridge,Mass.), 153, 2013
|
|
8W35
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8w35 by Molmil](/molmil-images/mine/8w35) | Aca2 from Pectobacterium phage ZF40 bound to RNA | Descriptor: | Anti-CRISPR associated (Aca) protein, Aca2, IR2 and IR-RBS RNA | Authors: | Wilkinson, M.E, Birkholz, N, Kimanius, D, Fineran, P.C. | Deposit date: | 2024-02-21 | Release date: | 2024-07-24 | Last modified: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (2.61 Å) | Cite: | Phage anti-CRISPR control by an RNA- and DNA-binding helix-turn-helix protein. Nature, 631, 2024
|
|
8UYF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8uyf by Molmil](/molmil-images/mine/8uyf) | Structure of nucleotide-free Pediculus humanus (Ph) PINK1 dimer | Descriptor: | Serine/threonine-protein kinase Pink1, mitochondrial | Authors: | Gan, Z.Y, Kirk, N.S, Leis, A, Komander, D. | Deposit date: | 2023-11-13 | Release date: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (2.75 Å) | Cite: | Interaction of PINK1 with nucleotides and kinetin. Sci Adv, 10, 2024
|
|
8UYH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8uyh by Molmil](/molmil-images/mine/8uyh) | Structure of AMP-PNP-bound Pediculus humanus (Ph) PINK1 dimer | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Pink1, ... | Authors: | Gan, Z.Y, Kirk, N.S, Leis, A, Komander, D. | Deposit date: | 2023-11-13 | Release date: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Interaction of PINK1 with nucleotides and kinetin. Sci Adv, 10, 2024
|
|
5HIA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5hia by Molmil](/molmil-images/mine/5hia) | Human hypoxanthine-guanine phosphoribosyltransferase in complex with [3R,4R]-4-guanin-9-yl-3-((S)-2-hydroxy-2-phosphonoethyl)oxy-1-N-(phosphonopropionyl)pyrrolidine | Descriptor: | Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION, [3-[(3~{R},4~{R})-3-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-[(2~{S})-2-oxidanyl-2-phosphono-ethoxy]pyrrolidin-1-y l]-3-oxidanylidene-propyl]phosphonic acid | Authors: | Guddat, L.W, Keough, D.T, Rejman, D. | Deposit date: | 2016-01-11 | Release date: | 2017-01-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.773 Å) | Cite: | Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics. ACS Chem. Biol., 2017
|
|
7MVZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7mvz by Molmil](/molmil-images/mine/7mvz) | Single particle cryo-EM structure of the Chaetomium thermophilum Nup188-Nic96-Nup145N complex (Nup188 residues 1-1858; Nic96 residues 240-301; Nup145N residues 640-732) | Descriptor: | Nucleoporin NIC96, Nucleoporin NUP145N, Nucleoporin NUP188 | Authors: | Petrovic, S, Samanta, D, Perriches, T, Bley, C.J, Thierbach, K, Brown, B, Nie, S, Mobbs, G.W, Stevens, T.A, Liu, X, Tomaleri, G.P, Schaus, L, Hoelz, A. | Deposit date: | 2021-05-15 | Release date: | 2022-06-15 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.81 Å) | Cite: | Architecture of the linker-scaffold in the nuclear pore. Science, 376, 2022
|
|
7MVW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7mvw by Molmil](/molmil-images/mine/7mvw) | Crystal structure of Chaetomium thermophilum Nup188 NTD (residues 1-1134) | Descriptor: | GLYCEROL, Nucleoporin NUP188 | Authors: | Petrovic, S, Samanta, D, Perriches, T, Bley, C.J, Thierbach, K, Brown, B, Nie, S, Mobbs, G.W, Stevens, T.A, Liu, X, Tomaleri, G.P, Schaus, L, Hoelz, A. | Deposit date: | 2021-05-15 | Release date: | 2022-06-15 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | Architecture of the linker-scaffold in the nuclear pore. Science, 376, 2022
|
|
7MVT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7mvt by Molmil](/molmil-images/mine/7mvt) | Crystal structure of the Chaetomium thermophilum Nup192-Nic96 complex (Nup192 residues 185-1756; Nic96 residues 187-301) | Descriptor: | Nucleoporin NIC96, Nucleoporin NUP192 | Authors: | Petrovic, S, Samanta, D, Perriches, T, Bley, C.J, Thierbach, K, Brown, B, Nie, S, Mobbs, G.W, Stevens, T.A, Liu, X, Tomaleri, G.P, Schaus, L, Hoelz, A. | Deposit date: | 2021-05-15 | Release date: | 2022-06-15 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Architecture of the linker-scaffold in the nuclear pore. Science, 376, 2022
|
|
7MVV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7mvv by Molmil](/molmil-images/mine/7mvv) | Single particle cryo-EM structure of the Chaetomium thermophilum Nup192-Nic96-Nup53-Nup145N complex (Nup192 residues 1-1756; Nic96 residues 240-301; Nup53 31-67; Nup145N 616-683) | Descriptor: | Nucleoporin NIC96, Nucleoporin NUP145N, Nucleoporin NUP192, ... | Authors: | Petrovic, S, Samanta, D, Perriches, T, Bley, C.J, Thierbach, K, Brown, B, Nie, S, Mobbs, G.W, Stevens, T.A, Liu, X, Tomaleri, G.P, Schaus, L, Hoelz, A. | Deposit date: | 2021-05-15 | Release date: | 2022-06-15 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.22 Å) | Cite: | Architecture of the linker-scaffold in the nuclear pore. Science, 376, 2022
|
|
7MW1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7mw1 by Molmil](/molmil-images/mine/7mw1) | Crystal structure of the Homo sapiens NUP93-NUP53 complex (NUP93 residues 174-819; NUP53 residues 84-150) | Descriptor: | Nuclear pore complex protein Nup93, Nucleoporin Nup35 | Authors: | Petrovic, S, Samanta, D, Perriches, T, Bley, C.J, Thierbach, K, Brown, B, Nie, S, Mobbs, G.W, Stevens, T.A, Liu, X, Tomaleri, G.P, Schaus, L, Hoelz, A. | Deposit date: | 2021-05-15 | Release date: | 2022-06-15 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Architecture of the linker-scaffold in the nuclear pore. Science, 376, 2022
|
|
7MVU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7mvu by Molmil](/molmil-images/mine/7mvu) | Single particle cryo-EM structure of the Chaetomium thermophilum Nup192-Nic96 complex (Nup192 residues 1-1756; Nic96 residues 240-301) | Descriptor: | Nucleoporin NIC96, Nucleoporin NUP192 | Authors: | Petrovic, S, Samanta, D, Perriches, T, Bley, C.J, Thierbach, K, Brown, B, Nie, S, Mobbs, G.W, Stevens, T.A, Liu, X, Tomaleri, G.P, Schaus, L, Hoelz, A. | Deposit date: | 2021-05-15 | Release date: | 2022-06-15 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.77 Å) | Cite: | Architecture of the linker-scaffold in the nuclear pore. Science, 376, 2022
|
|