PDB クエリの検索結果 - 日本蛋白質構造データバンク

PDB: 3 件

Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model
分子名称:	N-[2-(2,6-dichlorophenyl)-1H-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide, Non-receptor tyrosine-protein kinase TYK2
著者	Ultsch, M.H, Magnuson, S.
登録日	2017-06-26
公開日	2017-09-06
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (2.45 Å)
主引用文献	Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model. Bioorg. Med. Chem. Lett., 27, 2017

Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model
分子名称:	N-[2-(2,6-dichlorophenyl)-1H-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide, Tyrosine-protein kinase JAK2
著者	Ultsch, M.H, Magnuson, S.
登録日	2017-07-10
公開日	2017-09-06
最終更新日	2023-11-15
実験手法	X-RAY DIFFRACTION (1.854 Å)
主引用文献	Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model. Bioorg. Med. Chem. Lett., 27, 2017

Tyk2 (JH1) in complex with adenosine di-phosphate
分子名称:	ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Non-receptor tyrosine-protein kinase TYK2
著者	Liang, J, Abbema, A.V, Bao, L, Barrett, K, Beresini, M, Berezhkovskiy, L, Blair, W, Chang, C, Driscoll, J, Eigenbrot, C, Ghilardi, N, Gibbons, P, Halladay, J, Johnson, A, Kohli, P.B, Lai, Y, Liimatta, M, Mantik, P, Menghrajani, K, Murray, J, Sambrone, A, Shao, Y, Shia, S, Shin, Y, Smith, J, Sohn, S, Stanley, M, Tsui, V, Ultsch, M, Wu, L, Zhang, B, Magnuson, S.
登録日	2012-08-30
公開日	2013-08-14
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2.03 Å)
主引用文献	Lead identification of novel and selective TYK2 inhibitors. Eur.J.Med.Chem., 67, 2013