8G46
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![BU of 8g46 by Molmil](/molmil-images/mine/8g46) | Cryo-EM structure of DDB1deltaB-DDA1-DCAF16-BRD4(BD2)-MMH2 | Descriptor: | Bromodomain-containing protein 4, DDB1- and CUL4-associated factor 16, DET1- and DDB1-associated protein 1, ... | Authors: | Ma, M.W, Hunkeler, M, Jin, C.Y, Fischer, E.S. | Deposit date: | 2023-02-08 | Release date: | 2023-03-08 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders. Biorxiv, 2023
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6U42
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![BU of 6u42 by Molmil](/molmil-images/mine/6u42) | Natively decorated ciliary doublet microtubule | Descriptor: | DC1, DC2, DC3, ... | Authors: | Ma, M, Stoyanova, M, Rademacher, G, Dutcher, S.K, Brown, A, Zhang, R. | Deposit date: | 2019-08-22 | Release date: | 2019-11-13 | Last modified: | 2020-01-08 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure of the Decorated Ciliary Doublet Microtubule. Cell, 179, 2019
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8FRR
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![BU of 8frr by Molmil](/molmil-images/mine/8frr) | Wild-type myocilin olfactomedin domain | Descriptor: | CALCIUM ION, GLYCEROL, Myocilin, ... | Authors: | Ma, M.T, Lieberman, R.L, Huard, D.J.E. | Deposit date: | 2023-01-08 | Release date: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.27 Å) | Cite: | Competition between inside-out unfolding and pathogenic aggregation in an amyloid-forming beta-propeller. Nat Commun, 15, 2024
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4Z5Q
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![BU of 4z5q by Molmil](/molmil-images/mine/4z5q) | Crystal structure of the LnmZ cytochrome P450 hydroxylase from the leinamycin biosynthetic pathway of Streptomyces atroolivaceus S-140 at 1.8 A resolution | Descriptor: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, CHLORIDE ION, Cytochrome P450 hydroxylase, ... | Authors: | Ma, M, Lohman, J, Rudolf, J, Miller, M.D, Cao, H, Osipiuk, J, Joachimiak, A, Phillips Jr, G.N, Shen, B, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2015-04-02 | Release date: | 2015-08-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.801 Å) | Cite: | Crystal structure of the LnmZ cytochrome P450 hydroxylase from the leinamycin biosynthetic pathway of Streptomyces atroolivaceus S-140 To be Published
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4Z5P
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![BU of 4z5p by Molmil](/molmil-images/mine/4z5p) | Crystal structure of the LnmA cytochrome P450 hydroxylase from the leinamycin biosynthetic pathway of Streptomyces atroolivaceus S-140 at 1.9 A resolution | Descriptor: | Cytochrome P450 hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, TRIETHYLENE GLYCOL | Authors: | Ma, M, Lohman, J, Rudolf, J, Miller, M.D, Cao, H, Osipiuk, J, Babnigg, G, Phillips Jr, G.N, Joachimiak, A, Shen, B, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2015-04-02 | Release date: | 2015-07-29 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of the LnmA cytochrome P450 hydroxylase from the leinamycin biosynthetic pathway of Streptomyces atroolivaceus S-140 To be Published
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7RTG
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![BU of 7rtg by Molmil](/molmil-images/mine/7rtg) | Crystal Structure of the Human Adenosine Deaminase 1 | Descriptor: | Adenosine deaminase, ZINC ION | Authors: | Ma, M.T, Lieberman, R.L, Blazeck, J, Jennings, M.R. | Deposit date: | 2021-08-13 | Release date: | 2022-01-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.591 Å) | Cite: | Catalytically active holo Homo sapiens adenosine deaminase I adopts a closed conformation. Acta Crystallogr D Struct Biol, 78, 2022
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7CU6
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![BU of 7cu6 by Molmil](/molmil-images/mine/7cu6) | lasso peptide C24 mutant - A11V2C | Descriptor: | lasso peptide C24_A11V2C | Authors: | Ma, M, Liu, X.H. | Deposit date: | 2020-08-21 | Release date: | 2021-08-25 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Rational generation of lasso peptides based on biosynthetic gene mutations and site-selective chemical modifications. Chem Sci, 12, 2021
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7XRF
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![BU of 7xrf by Molmil](/molmil-images/mine/7xrf) | Crystal structaure of DgpB/C complex | Descriptor: | AP_endonuc_2 domain-containing protein, DgpB, MANGANESE (II) ION | Authors: | Ma, M, He, P. | Deposit date: | 2022-05-10 | Release date: | 2023-02-15 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.137 Å) | Cite: | Structural mechanism of a dual-functional enzyme DgpA/B/C as both a C -glycoside cleaving enzyme and an O - to C -glycoside isomerase. Acta Pharm Sin B, 13, 2023
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4ZXW
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![BU of 4zxw by Molmil](/molmil-images/mine/4zxw) | Crystal structure of SgcC5 protein from Streptomyces globisporus (complex with (R)-(-)-1-(2-naphthyl)-1,2-ethanediol and sucrose) | Descriptor: | (1R)-1-(naphthalen-2-yl)ethane-1,2-diol, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, C-domain type II peptide synthetase, ... | Authors: | Michalska, K, Bigelow, L, Jedrzejczak, R, Babnigg, G, Lohman, J, Ma, M, Rudolf, J, Chang, C.-Y, Shen, B, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2015-05-20 | Release date: | 2015-06-17 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.187 Å) | Cite: | Crystal structure of SgcC5 protein from Streptomyces globisporus To Be Published
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7YUA
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![BU of 7yua by Molmil](/molmil-images/mine/7yua) | |
7YV0
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![BU of 7yv0 by Molmil](/molmil-images/mine/7yv0) | |
6LK3
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![BU of 6lk3 by Molmil](/molmil-images/mine/6lk3) | The Functional Characterization and Crystal Structure of Type II Peptidyl Carrier Protein ColA1a in Collismycins Biosynthesis | Descriptor: | Putative free-standing acyl carrier protein | Authors: | Ma, X.Y, Wang, G.Y, Liu, T, Chi, C.B, Zhang, Z.Y, Yang, D.H, Liu, W, Ma, M. | Deposit date: | 2019-12-18 | Release date: | 2020-10-28 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The functional characterization and crystal structure of type II peptidyl carrier protein ColA1a in collismycins biosynthesis. Chin.J.Chem., 38, 2020
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4ZNM
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![BU of 4znm by Molmil](/molmil-images/mine/4znm) | Crystal structure of SgcC5 protein from Streptomyces globisporus (apo form) | Descriptor: | C-domain type II peptide synthetase, CHLORIDE ION, SODIUM ION | Authors: | Michalska, K, Bigelow, L, Jedrzejczak, R, Babnigg, G, Lohman, J, Ma, M, Rudolf, J, Chang, C.-Y, Shen, B, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2015-05-04 | Release date: | 2015-05-27 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (1.998 Å) | Cite: | Crystal structure of SgcC5 protein from Streptomyces globisporus (apo form) To Be Published
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7DMO
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7DMN
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![BU of 7dmn by Molmil](/molmil-images/mine/7dmn) | Crystal structure of two pericyclases catalyzing [4+2] cycloaddition | Descriptor: | Diels-Alderase fsa2, GLYCEROL | Authors: | Chi, C.B, Wang, Z.D, Liu, T, Zhang, Z.Y, Ma, M. | Deposit date: | 2020-12-04 | Release date: | 2021-10-06 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structures of Fsa2 and Phm7 Catalyzing [4 + 2] Cycloaddition Reactions with Reverse Stereoselectivities in Equisetin and Phomasetin Biosynthesis. Acs Omega, 6, 2021
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8Y74
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8YLA
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![BU of 8yla by Molmil](/molmil-images/mine/8yla) | Crystal structures of terpene synthases complexed with a substrate mimic | Descriptor: | MAGNESIUM ION, N-benzyl-N,N-diethylethanaminium, PYROPHOSPHATE, ... | Authors: | Xu, M, Ma, M. | Deposit date: | 2024-03-05 | Release date: | 2024-04-24 | Last modified: | 2024-06-12 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structural Insights Into the Terpene Cyclization Domains of Two Fungal Sesterterpene Synthases and Enzymatic Engineering for Sesterterpene Diversification. Angew.Chem.Int.Ed.Engl., 63, 2024
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8YL9
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![BU of 8yl9 by Molmil](/molmil-images/mine/8yl9) | Crystal structures of terpene synthases complexed with a substrate mimic | Descriptor: | MAGNESIUM ION, N-benzyl-N,N-diethylethanaminium, PYROPHOSPHATE, ... | Authors: | Xu, M, Ma, M. | Deposit date: | 2024-03-05 | Release date: | 2024-04-24 | Last modified: | 2024-06-12 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural Insights Into the Terpene Cyclization Domains of Two Fungal Sesterterpene Synthases and Enzymatic Engineering for Sesterterpene Diversification. Angew.Chem.Int.Ed.Engl., 63, 2024
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6M19
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![BU of 6m19 by Molmil](/molmil-images/mine/6m19) | Template lasso peptide C24 mutant W14F | Descriptor: | lasso peptide | Authors: | Liu, X.H, Liu, T, Ma, X.J, Yu, J.H, Yang, D.H, Ma, M. | Deposit date: | 2020-02-25 | Release date: | 2021-03-03 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Rational generation of lasso peptides based on biosynthetic gene mutations and site-selective chemical modifications. Chem Sci, 12, 2021
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7JU4
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![BU of 7ju4 by Molmil](/molmil-images/mine/7ju4) | Radial spoke 2 stalk, IDAc, and N-DRC attached with doublet microtubule | Descriptor: | 28 kDa inner dynein arm light chain, axonemal, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Gui, M, Ma, M, Sze-Tu, E, Wang, X, Koh, F, Zhong, E, Berger, B, Davis, J, Dutcher, S, Zhang, R, Brown, A. | Deposit date: | 2020-08-19 | Release date: | 2020-12-16 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structures of radial spokes and associated complexes important for ciliary motility. Nat.Struct.Mol.Biol., 28, 2021
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7JTK
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![BU of 7jtk by Molmil](/molmil-images/mine/7jtk) | Radial spoke 1 isolated from Chlamydomonas reinhardtii | Descriptor: | Cytochrome b5 heme-binding domain-containing protein, Dynein 8 kDa light chain, flagellar outer arm, ... | Authors: | Gui, M, Ma, M, Sze-Tu, E, Wang, X, Koh, F, Zhong, E, Berger, B, Davis, J, Dutcher, S, Zhang, R, Brown, A. | Deposit date: | 2020-08-17 | Release date: | 2020-12-16 | Last modified: | 2021-01-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structures of radial spokes and associated complexes important for ciliary motility. Nat.Struct.Mol.Biol., 28, 2021
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4WKY
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![BU of 4wky by Molmil](/molmil-images/mine/4wky) | Streptomcyes albus JA3453 oxazolomycin ketosynthase domain OzmN KS2 | Descriptor: | 1,2-ETHANEDIOL, Beta-ketoacyl synthase, GLYCEROL, ... | Authors: | Cuff, M.E, Mack, J.C, Endres, M, Babnigg, G, Bingman, C.A, Yennamalli, R, Lohman, J.R, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2014-10-03 | Release date: | 2014-10-29 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases. Proc.Natl.Acad.Sci.USA, 112, 2015
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5BMO
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![BU of 5bmo by Molmil](/molmil-images/mine/5bmo) | LnmX protein, a putative GlcNAc-PI de-N-acetylase from Streptomyces atroolivaceus | Descriptor: | ACETATE ION, POTASSIUM ION, Putative uncharacterized protein LnmX | Authors: | Osipiuk, J, Hatzos-Skintges, C, Cuff, M, Endres, M, Babnigg, G, Lohman, J, Ma, M, Rudolf, J, Chang, C.-Y, Shen, B, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2015-05-22 | Release date: | 2015-06-10 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | LnmX protein, a putative GlcNAc-PI de-N-acetylase from Streptomyces atroolivaceus. to be published
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7N7V
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![BU of 7n7v by Molmil](/molmil-images/mine/7n7v) | Crystal structure of TtnM, a Fe(II)-alpha-ketoglutarate-dependent hydroxylase from the tautomycetin biosynthesis pathway in Streptomyces griseochromogenes at 2 A. | Descriptor: | CHLORIDE ION, FE (II) ION, Predicted hydroxylase | Authors: | Han, L, Xu, W, Ma, M, Miller, M.D, Shen, B, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2021-06-11 | Release date: | 2022-07-06 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structure of TtnM, a Fe(II)-alpha-ketoglutarate-dependent hydroxylase from the tautomycetin biosynthesis pathway in Streptomyces griseochromogenes. To Be Published
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4QYR
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![BU of 4qyr by Molmil](/molmil-images/mine/4qyr) | Streptomyces platensis isomigrastatin ketosynthase domain MgsE KS3 | Descriptor: | ACETIC ACID, AT-less polyketide synthase, CHLORIDE ION, ... | Authors: | Kim, Y, Li, H, Endres, M, Babnigg, J, Bingman, C.A, Yennamalli, R, Lohman, J.R, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2014-07-25 | Release date: | 2014-08-20 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.902 Å) | Cite: | Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases. Proc.Natl.Acad.Sci.USA, 112, 2015
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