8IGS
| Cryo-EM structure of RNAP-promoter open complex at lambda promoter PRE | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Zhao, M, Gao, B, Wen, A, Feng, Y, Lu, Y. | Deposit date: | 2023-02-21 | Release date: | 2023-05-17 | Last modified: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis of lambda CII-dependent transcription activation. Structure, 31, 2023
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8IDP
| Crystal structure of reducing-end xylose-releasing exoxylanase in GH30 from Talaromyces cellulolyticus | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ... | Authors: | Nakamichi, Y, Watanabe, M, Fujii, T, Inoue, H, Morita, T. | Deposit date: | 2023-02-14 | Release date: | 2023-05-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of reducing-end xylose-releasing exoxylanase in subfamily 7 of glycoside hydrolase family 30. Proteins, 91, 2023
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4UMR
| Structure of MELK in complex with inhibitors | Descriptor: | 4-fluoro-N-(1,2,3,4-tetrahydroisoquinolin-7-yl)benzamide, MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE | Authors: | Johnson, C.N, Berdini, V, Beke, L, Bonnet, P, Brehmer, D, Coyle, J.E, Day, P.J, Frederickson, M, Freyne, E.J.E, Gilissen, R.A.H.J, Hamlett, C.C.F, Howard, S, Meerpoel, L, McMenamin, R, Patel, S, Rees, D.C, Sharff, A, Sommen, F, Wu, T, Linders, J.T.M. | Deposit date: | 2014-05-20 | Release date: | 2014-10-08 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase Acs Med.Chem.Lett., 6, 2015
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8QDG
| compound 1a bound KMT9 crystal structure | Descriptor: | (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[(3~{S})-pyrrolidin-3-yl]amino]-2-azanyl-butanoic acid, Methyltransferase N6AMT1, Multifunctional methyltransferase subunit TRM112-like protein | Authors: | Sheng, W, Eric, M, Roland, S. | Deposit date: | 2023-08-29 | Release date: | 2024-09-11 | Method: | X-RAY DIFFRACTION (1.392 Å) | Cite: | compound 1a bound KMT9 crystal structure To Be Published
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4UR3
| Crystal structure of the PCE reductive dehalogenase from S. multivorans P2(1) crystal form | Descriptor: | IRON/SULFUR CLUSTER, NORPSEUDO-B12, TETRACHLOROETHENE REDUCTIVE DEHALOGENASE CATALYTIC SUBUNIT | Authors: | Bommer, M, Kunze, C, Fesseler, J, Schubert, T, Diekert, G, Dobbek, H. | Deposit date: | 2014-06-25 | Release date: | 2014-10-15 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.235 Å) | Cite: | Structural Basis for Organohalide Respiration. Science, 346, 2014
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8QDI
| compound 1b bound KMT9 crystal structure | Descriptor: | (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[2-[(2~{R})-pyrrolidin-2-yl]ethyl]amino]-2-azanyl-butanoic acid, Methyltransferase N6AMT1, Multifunctional methyltransferase subunit TRM112-like protein | Authors: | Sheng, W, Eric, M, Roland, S. | Deposit date: | 2023-08-29 | Release date: | 2024-09-11 | Method: | X-RAY DIFFRACTION (1.467 Å) | Cite: | compound 1a bound KMT9 crystal structure To Be Published
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4UR0
| Crystal structure of the PCE reductive dehalogenase from S. multivorans in complex with trichloroethene | Descriptor: | 1,1,2-trichloroethene, BENZAMIDINE, GLYCEROL, ... | Authors: | Bommer, M, Kunze, C, Fesseler, J, Schubert, T, Diekert, G, Dobbek, H. | Deposit date: | 2014-06-25 | Release date: | 2014-10-15 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.798 Å) | Cite: | Structural Basis for Organohalide Respiration. Science, 346, 2014
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8QF9
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4V7F
| Arx1 pre-60S particle. | Descriptor: | 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | Authors: | Leidig, C, Thoms, M, Holdermann, I, Bradatsch, B, Berninghausen, O, Bange, G, Sinning, I, Hurt, E, Beckmann, R. | Deposit date: | 2013-12-10 | Release date: | 2014-07-09 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (8.7 Å) | Cite: | 60S ribosome biogenesis requires rotation of the 5S ribonucleoprotein particle. Nat Commun, 5, 2014
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8QJ5
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8HR3
| [D-Cys5,Asp7,Val8,D-Lys16]-STp(5-17) | Descriptor: | DCY-CYS-ASP-VAL-CYS-CYS-ASN-PRO-ALA-CYS-ALA-DLY-CYS | Authors: | Shimamoto, S, Hidaka, Y, Yoshino, S, Goto, M. | Deposit date: | 2022-12-14 | Release date: | 2023-09-20 | Method: | SOLUTION NMR | Cite: | The Molecular Basis of Heat-Stable Enterotoxin for Vaccine Development and Cancer Cell Detection. Molecules, 28, 2023
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4UZ1
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8GX2
| The crystal structure of human CtsL in complex with 14c | Descriptor: | DIMETHYL SULFOXIDE, N-[(2S)-3-cyclohexyl-1-[[(2S,3S)-4-(cyclopropylamino)-3-oxidanyl-4-oxidanylidene-1-[(3S)-2-oxidanylidenepiperidin-3-yl]butan-2-yl]amino]-1-oxidanylidene-propan-2-yl]-1-benzofuran-2-carboxamide, Procathepsin L | Authors: | Zhao, Y, Shao, M, Zhao, J, Yang, H, Rao, Z. | Deposit date: | 2022-09-18 | Release date: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The crystal structure of human CtsL in complex with 14a To Be Published
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4USN
| The structure of the immature HIV-1 capsid in intact virus particles at sub-nm resolution | Descriptor: | P24 | Authors: | Schur, F.K.M, Hagen, W.J.H, Rumlova, M, Ruml, T, Mueller, B, Kraeusslich, H.-G, Briggs, J.A.G. | Deposit date: | 2014-07-11 | Release date: | 2014-11-05 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (8.8 Å) | Cite: | Structure of the Immature HIV-1 Capsid in Intact Virus Particles at 8.8 A Resolution. Nature, 517, 2015
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4UVN
| Crystal structure of human tankyrase 2 in complex with 5-amino-3-(4- chlorophenyl)-1,2-dihydroisoquinolin-1-one | Descriptor: | 5-amino-3-(4-chlorophenyl)isoquinolin-1(2H)-one, GLYCEROL, SULFATE ION, ... | Authors: | Narwal, M, Haikarainen, T, Lehtio, L. | Deposit date: | 2014-08-07 | Release date: | 2015-07-29 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Exploration of the Nicotinamide-Binding Site of the Tankyrases, Identifying 3-Arylisoquinolin-1-Ones as Potent and Selective Inhibitors in Vitro. Bioorg.Med.Chem., 23, 2015
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6ML1
| Structure of the USP15 deubiquitinase domain in complex with an affinity-matured inhibitory Ubv | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Singer, A.U, Teyra, J, Boehmelt, G, Lenter, M, Sicheri, F, Sidhu, S.S. | Deposit date: | 2018-09-26 | Release date: | 2019-01-23 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15. Structure, 27, 2019
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4V1A
| Structure of the large subunit of the mammalian mitoribosome, part 2 of 2 | Descriptor: | MITORIBOSOMAL PROTEIN ML37, MRPL37, MITORIBOSOMAL PROTEIN ML38, ... | Authors: | Greber, B.J, Boehringer, D, Leibundgut, M, Bieri, P, Leitner, A, Schmitz, N, Aebersold, R, Ban, N. | Deposit date: | 2014-09-25 | Release date: | 2014-10-08 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | The Complete Structure of the Large Subunit of the Mammalian Mitochondrial Ribosome Nature, 515, 2014
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8QDE
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6MRT
| 12-meric ClyA pore complex | Descriptor: | Hemolysin E, chromosomal | Authors: | Peng, W, de Souza Santos, M, Li, Y, Tomchick, D.R, Orth, K. | Deposit date: | 2018-10-15 | Release date: | 2019-05-15 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers. Plos One, 14, 2019
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4US3
| Crystal Structure of the bacterial NSS member MhsT in an Occluded Inward-Facing State | Descriptor: | DODECYL-ALPHA-D-MALTOSIDE, SODIUM ION, TRANSPORTER, ... | Authors: | Malinauskaite, L, Quick, M, Reinhard, L, Lyons, J.A, Yano, H, Javitch, J.A, Nissen, P. | Deposit date: | 2014-07-02 | Release date: | 2014-09-24 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.098 Å) | Cite: | A Mechanism for Intracellular Release of Na+ by Neurotransmitter/Sodium Symporters Nat.Struct.Mol.Biol., 21, 2014
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8QHO
| Human Carbonic Anhydrase II in complex with 3,4-dihydro-1H-benzo[c][1,2]oxaborinin-1-ol | Descriptor: | 1,1-bis(oxidanyl)-3,4-dihydro-2,1$l^{4}-benzoxaborinine, Carbonic anhydrase 2, GLYCEROL, ... | Authors: | Angeli, A, Ferraroni, M. | Deposit date: | 2023-09-08 | Release date: | 2024-09-18 | Method: | X-RAY DIFFRACTION (1.43 Å) | Cite: | Human Carbonic Anhydrase II in complex with 3,4-dihydro-1H-benzo[c][1,2]oxaborinin-1-ol To Be Published
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4UXT
| Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, KINESIN HEAVY CHAIN ISOFORM 5A, ... | Authors: | Atherton, J, Farabella, I, Yu, I.M, Rosenfeld, S.S, Houdusse, A, Topf, M, Moores, C. | Deposit date: | 2014-08-27 | Release date: | 2014-09-24 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (7.4 Å) | Cite: | Conserved Mechanisms of Microtubule-Stimulated Adp Release, ATP Binding, and Force Generation in Transport Kinesins. Elife, 3, 2014
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8GWJ
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4UY2
| Crystal structure of the complex of the extracellular domain of human alpha9 nAChR with alpha-bungarotoxin. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-BUNGAROTOXIN ISOFORM V31, NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-9 | Authors: | Giastas, P, Zouridakis, M, Zarkadas, E, Tzartos, S.J. | Deposit date: | 2014-08-28 | Release date: | 2014-10-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.697 Å) | Cite: | Crystal Structures of Free and Antagonist-Bound States of Human Alpha9 Nicotinic Receptor Extracellular Domain Nat.Struct.Mol.Biol., 21, 2014
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8GXI
| The crystal structure of SARS-CoV-2 main protease in complex with 14c | Descriptor: | 3C-like proteinase nsp5, N-[(2S)-3-cyclohexyl-1-[[(2S,3R)-4-(cyclopropylamino)-3-oxidanyl-4-oxidanylidene-1-[(3S)-2-oxidanylidenepiperidin-3-yl]butan-2-yl]amino]-1-oxidanylidene-propan-2-yl]-1-benzofuran-2-carboxamide | Authors: | Zhao, Y, Zhao, J, Shao, M, Yang, H, Rao, Z. | Deposit date: | 2022-09-20 | Release date: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | The crystal structure of SARS-CoV-2 main protease in complex with 14c To Be Published
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