4AB7
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![BU of 4ab7 by Molmil](/molmil-images/mine/4ab7) | Crystal structure of a tetrameric acetylglutamate kinase from Saccharomyces cerevisiae complexed with its substrate N- acetylglutamate | Descriptor: | N-ACETYL-L-GLUTAMATE, PROTEIN ARG5,6, MITOCHONDRIAL | Authors: | de Cima, S, Gil-Ortiz, F, Crabeel, M, Fita, I, Rubio, V. | Deposit date: | 2011-12-07 | Release date: | 2012-05-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Insight on an Arginine Synthesis Metabolon from the Tetrameric Structure of Yeast Acetylglutamate Kinase Plos One, 7, 2012
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2MW2
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![BU of 2mw2 by Molmil](/molmil-images/mine/2mw2) | Hha-H-NS46 charge zipper complex | Descriptor: | DNA-binding protein H-NS, Hemolysin expression-modulating protein Hha | Authors: | Cordeiro, T.N, Garcia, J, Bernado, P, Millet, O, Pons, M. | Deposit date: | 2014-10-24 | Release date: | 2015-07-29 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | A Three-protein Charge Zipper Stabilizes a Complex Modulating Bacterial Gene Silencing. J. Biol. Chem., 290, 2015
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4AOF
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![BU of 4aof by Molmil](/molmil-images/mine/4aof) | Selective small molecule inhibitor discovered by chemoproteomic assay platform reveals regulation of Th17 cell differentiation by PI3Kgamma | Descriptor: | N-[6-(5-methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]ethanamide, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM | Authors: | Bergamini, G, Bell, K, Shimamura, S, Werner, T, Cansfield, A, Muller, K, Perrin, J, Rau, C, Ellard, K, Hopf, C, Doce, C, Leggate, D, Mangano, R, Mathieson, T, OMahony, A, Plavec, I, Rharbaoui, F, Reinhard, F, Savitski, M.M, Ramsden, N, Hirsch, E, Drewes, G, Rausch, O, Bantscheff, M, Neubauer, G. | Deposit date: | 2012-03-26 | Release date: | 2012-05-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | A Selective Inhibitor Reveals Pi3Kgamma Dependence of T(H)17 Cell Differentiation. Nat.Chem.Biol., 8, 2012
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4A0V
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![BU of 4a0v by Molmil](/molmil-images/mine/4a0v) | model refined against the Symmetry-free cryo-EM map of TRiC-AMP-PNP | Descriptor: | T-COMPLEX PROTEIN 1 SUBUNIT BETA | Authors: | Cong, Y, Schroder, G.F, Meyer, A.S, Jakana, J, Ma, B, Dougherty, M.T, Schmid, M.F, Reissmann, S, Levitt, M, Ludtke, S.L, Frydman, J, Chiu, W. | Deposit date: | 2011-09-13 | Release date: | 2012-02-15 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (10.7 Å) | Cite: | Symmetry-Free Cryo-Em Structures of the Chaperonin Tric Along its ATPase-Driven Conformational Cycle. Embo J., 31, 2012
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1NNO
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![BU of 1nno by Molmil](/molmil-images/mine/1nno) | CONFORMATIONAL CHANGES OCCURRING UPON NO BINDING IN NITRITE REDUCTASE FROM PSEUDOMONAS AERUGINOSA | Descriptor: | HEME C, HEME D, NITRIC OXIDE, ... | Authors: | Nurizzo, D, Tegoni, M, Cambillau, C. | Deposit date: | 1998-07-20 | Release date: | 1999-04-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Conformational changes occurring upon reduction and NO binding in nitrite reductase from Pseudomonas aeruginosa. Biochemistry, 37, 1998
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4A1Y
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![BU of 4a1y by Molmil](/molmil-images/mine/4a1y) | Human myelin P2 protein, K65Q mutant | Descriptor: | CHLORIDE ION, MYELIN P2 PROTEIN, PALMITIC ACID | Authors: | Lehtimaki, M, Kursula, P. | Deposit date: | 2011-09-20 | Release date: | 2012-10-10 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Structure-Function Relationships in the Myelin Peripheral Membrane Protein P2 To be Published
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2MPV
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![BU of 2mpv by Molmil](/molmil-images/mine/2mpv) | Structural insight into host recognition and biofilm formation by aggregative adherence fimbriae of enteroaggregative Esherichia coli | Descriptor: | Major fimbrial subunit of aggregative adherence fimbria II AafA | Authors: | Matthews, S.J, Yang, Y, Berry, A.A, Pakharukova, N, Garnett, J.A, Lee, W, Cota, E, Liu, B, Roy, S, Tuittila, M, Marchant, J, Inman, K.G, Ruiz-Perez, F, Mandomando, I, Nataro, J.P, Zavialov, A.V. | Deposit date: | 2014-06-04 | Release date: | 2014-10-29 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structural insight into host recognition by aggregative adherence fimbriae of enteroaggregative Escherichia coli. Plos Pathog., 10, 2014
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4A4Z
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![BU of 4a4z by Molmil](/molmil-images/mine/4a4z) | CRYSTAL STRUCTURE OF THE S. CEREVISIAE DEXH HELICASE SKI2 BOUND TO AMPPNP | Descriptor: | 1,2-ETHANEDIOL, ANTIVIRAL HELICASE SKI2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Halbach, F, Rode, M, Conti, E. | Deposit date: | 2011-10-20 | Release date: | 2011-12-21 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The Crystal Structure of S. Cerevisiae Ski2, a Dexh Helicase Associated with the Cytoplasmic Functions of the Exosome. RNA, 18, 2012
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2MQB
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![BU of 2mqb by Molmil](/molmil-images/mine/2mqb) | |
4AB3
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![BU of 4ab3 by Molmil](/molmil-images/mine/4ab3) | ATP-triggered molecular mechanics of the chaperonin GroEL | Descriptor: | 60 KDA CHAPERONIN, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Clare, D.K, Vasishtan, D, Stagg, S, Quispe, J, Farr, G.W, Topf, M, Horwich, A.L, Saibil, H.R. | Deposit date: | 2011-12-06 | Release date: | 2012-12-12 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (8.5 Å) | Cite: | ATP-Triggered Conformational Changes Delineate Substrate-Binding and -Folding Mechanics of the Groel Chaperonin. Cell(Cambridge,Mass.), 149, 2012
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2N2G
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4ZDV
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4ADX
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![BU of 4adx by Molmil](/molmil-images/mine/4adx) | The Cryo-EM Structure of the Archaeal 50S Ribosomal Subunit in Complex with Initiation Factor 6 | Descriptor: | 23S Ribosomal RNA EXPANSION SEGMENTS, 23S ribosomal RNA, 5S Ribosomal RNA, ... | Authors: | Greber, B.J, Boehringer, D, Godinic-Mikulcic, V, Crnkovic, A, Ibba, M, Weygand-Durasevic, I, Ban, N. | Deposit date: | 2012-01-04 | Release date: | 2012-02-08 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (6.6 Å) | Cite: | Cryo-Em Structure of the Archaeal 50S Ribosomal Subunit in Complex with Initiation Factor 6 and Implications for Ribosome Evolution J.Mol.Biol., 418, 2012
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2N0F
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![BU of 2n0f by Molmil](/molmil-images/mine/2n0f) | NMR structure of Neuromedin C in 60% TFE | Descriptor: | Neuromedin C (NMC) | Authors: | Adrover, M, Sanchis, P, Vilanova, B, Pauwels, K, Martorell, G, Perez, J. | Deposit date: | 2015-03-05 | Release date: | 2015-10-21 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Conformational ensembles of neuromedin C reveal a progressive coil-helix transition within a binding-induced folding mechanism. RSC ADV, 5, 2015
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2QH5
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![BU of 2qh5 by Molmil](/molmil-images/mine/2qh5) | Crystal structure of mannose-6-phosphate isomerase from Helicobacter pylori | Descriptor: | Mannose-6-phosphate isomerase | Authors: | Patskovsky, Y, Ramagopal, U, Toro, R, Sauder, J.M, Dickey, M, Iizuka, M, Maletic, M, Wasserman, S.R, Koss, J, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2007-06-29 | Release date: | 2007-07-17 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of Mannose-6-phosphate isomerase from Helicobacter pylori. To be Published
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2N79
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![BU of 2n79 by Molmil](/molmil-images/mine/2n79) | The structural and functional effects of the Familial Hypertrophic Cardiomyopathy-linked cardiac troponin C mutation, L29Q | Descriptor: | CALCIUM ION, Troponin C, slow skeletal and cardiac muscles | Authors: | Robertson, I.M, Sevrieva, I, Li, M.X, Irving, M, Sun, Y, Sykes, B. | Deposit date: | 2015-09-06 | Release date: | 2015-10-28 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The structural and functional effects of the familial hypertrophic cardiomyopathy-linked cardiac troponin C mutation, L29Q. J.MOL.CELL.CARDIOL., 87, 2015
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4AK1
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![BU of 4ak1 by Molmil](/molmil-images/mine/4ak1) | Structure of BT4661, a SusE-like surface located polysaccharide binding protein from the Bacteroides thetaiotaomicron heparin utilisation locus | Descriptor: | BT_4661, SODIUM ION | Authors: | Lowe, E.C, Basle, A, Czjzek, M, Thomas, S, Murray, H, Firbank, S.J, Bolam, D.N. | Deposit date: | 2012-02-21 | Release date: | 2013-03-06 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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2MWM
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4AKT
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![BU of 4akt by Molmil](/molmil-images/mine/4akt) | PatG macrocyclase in complex with peptide | Descriptor: | SUBSTRATE ANALOGUE, THIAZOLINE OXIDASE/SUBTILISIN-LIKE PROTEASE | Authors: | Koehnke, J, Bent, A, Houssen, W.E, Zollman, D, Morawitz, F, Shirran, S, Vendome, J, Nneoyiegbe, A.F, Trembleau, L, Botting, C.H, Smith, M.C.M, Jaspars, M, Naismith, J.H. | Deposit date: | 2012-02-28 | Release date: | 2012-07-18 | Last modified: | 2013-11-06 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | The Mechanism of Patellamide Macrocyclization Revealed by the Characterization of the Patg Macrocyclase Domain. Nat.Struct.Mol.Biol., 19, 2012
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4AGD
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![BU of 4agd by Molmil](/molmil-images/mine/4agd) | CRYSTAL STRUCTURE OF VEGFR2 (JUXTAMEMBRANE AND KINASE DOMAINS) IN COMPLEX WITH SUNITINIB (SU11248) (N-2-diethylaminoethyl)-5-((Z)-(5- fluoro-2-oxo-1H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3- carboxamide) | Descriptor: | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 | Authors: | McTigue, M, Deng, Y, Ryan, K, Brooun, A, Diehl, W, Stewart, A. | Deposit date: | 2012-01-26 | Release date: | 2012-09-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Molecular Conformations, Interactions, and Properties Associated with Drug Efficiency and Clinical Performance Among Vegfr Tk Inhibitors. Proc.Natl.Acad.Sci.USA, 109, 2012
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4AR2
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![BU of 4ar2 by Molmil](/molmil-images/mine/4ar2) | Dodecahedron formed of penton base protein from adenovirus Ad3 | Descriptor: | CALCIUM ION, FIBER PROTEIN, L2 PROTEIN III (PENTON BASE) | Authors: | Burmeister, W.P, Szolajska, E, Zochowska, M, Nerlo, B, Andreev, I, Schoehn, G, Andrieu, J.-P, Fender, P, Naskalska, A, Zubieta, C, Cusack, S, Chroboczek, J. | Deposit date: | 2012-04-20 | Release date: | 2012-10-24 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | The Structural Basis for the Integrity of Adenovirus Ad3 Dodecahedron. Plos One, 7, 2012
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4F11
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![BU of 4f11 by Molmil](/molmil-images/mine/4f11) | Crystal structure of the extracellular domain of human GABA(B) receptor GBR2 | Descriptor: | Gamma-aminobutyric acid type B receptor subunit 2 | Authors: | Geng, Y, Xiong, D, Mosyak, L, Malito, D.L, Kniazeff, J, Chen, Y, Burmakina, S, Quick, M, Bush, M, Javitch, J.A, Pin, J.-P, Fan, Q.R. | Deposit date: | 2012-05-05 | Release date: | 2012-06-06 | Last modified: | 2012-08-15 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Structure and functional interaction of the extracellular domain of human GABA(B) receptor GBR2. Nat.Neurosci., 15, 2012
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2JIN
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![BU of 2jin by Molmil](/molmil-images/mine/2jin) | Crystal structure of PDZ domain of Synaptojanin-2 binding protein | Descriptor: | SODIUM ION, SULFATE ION, SYNAPTOJANIN-2 BINDING PROTEIN | Authors: | Tickle, J, Phillips, C, Pike, A.C.W, Cooper, C, Salah, E, Elkins, J, Turnbull, A.P, Edwards, A, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Doyle, D. | Deposit date: | 2007-06-28 | Release date: | 2007-07-10 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal Structure of Pdz Domain of Synaptojanin-2 Binding Protein To be Published
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4AQG
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![BU of 4aqg by Molmil](/molmil-images/mine/4aqg) | X-ray crystallographic structure of Crimean-congo haemorrhagic fever virus nucleoprotein | Descriptor: | NUCLEOPROTEIN, SULFATE ION | Authors: | Wang, Y, Dutta, S, Karlberg, H, Devignot, S, Weber, F, Hao, Q, Tan, Y.J, Mirazimi, A, Kotaka, M. | Deposit date: | 2012-04-17 | Release date: | 2012-09-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of Crimean-Congo Haemorraghic Fever Virus Nucleoprotein: Superhelical Homo-Oligomers and the Role of Caspase-3 Cleavage. J.Virol., 86, 2012
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4AR4
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![BU of 4ar4 by Molmil](/molmil-images/mine/4ar4) | Neutron crystallographic structure of the reduced form perdeuterated Pyrococcus furiosus rubredoxin to 1.38 Angstrom resolution. | Descriptor: | FE (III) ION, Rubredoxin, deuterium(1+), ... | Authors: | Cuypers, M.G, Mason, S.A, Blakeley, M.P, Mitchell, E.P, Haertlein, M, Forsyth, V.T. | Deposit date: | 2012-04-20 | Release date: | 2013-01-16 | Last modified: | 2024-06-19 | Method: | NEUTRON DIFFRACTION (1.381 Å) | Cite: | Near-Atomic Resolution Neutron Crystallography on Perdeuterated Pyrococcus Furiosus Rubredoxin: Implication of Hydronium Ions and Protonation State Equilibria in Redox Changes. Angew.Chem.Int.Ed.Engl., 52, 2013
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