7ZMT
| Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G5-006 | Descriptor: | ATP-dependent DNA helicase Q5, Gluebody G5-006, ZINC ION | Authors: | Ye, M, Makola, M, Newman, J.A, Fairhead, M, MacLean, E, Krojer, T, Aitkenhead, H, Bountra, C, Gileadi, O, von Delft, F. | Deposit date: | 2022-04-19 | Release date: | 2022-06-22 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive crystal contacts To Be Published
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6YDB
| Human wtSTING in complex with 2',2'-difluoro-3',3'-c-di-GMP | Descriptor: | 2-azanyl-9-[(1~{R},6~{R},8~{R},9~{R},10~{R},15~{R},17~{R},18~{R})-17-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadecan-8-yl]-1~{H}-purin-6-one, Stimulator of interferon protein | Authors: | Boura, E, Smola, M. | Deposit date: | 2020-03-20 | Release date: | 2021-03-31 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.801 Å) | Cite: | Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein. Angew.Chem.Int.Ed.Engl., 60, 2021
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7ZMV
| Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G5-006 | Descriptor: | ATP-dependent DNA helicase Q5, Gluebody G5-006, SULFATE ION, ... | Authors: | Ye, M, Makola, M, Newman, J.A, Fairhead, M, MacLean, E, Krojer, T, Aitkenhead, H, Bountra, C, Gileadi, O, von Delft, F. | Deposit date: | 2022-04-19 | Release date: | 2022-06-22 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.002 Å) | Cite: | Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive crystal contacts To Be Published
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6YDZ
| Human wtSTING in complex with 3',3'-cGAMP | Descriptor: | 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, Stimulator of interferon protein | Authors: | Boura, E, Smola, M. | Deposit date: | 2020-03-23 | Release date: | 2021-03-31 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein. Angew.Chem.Int.Ed.Engl., 60, 2021
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7ZMP
| Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G3-055 | Descriptor: | ATP-dependent DNA helicase Q5, Gluebody G3-055, ZINC ION | Authors: | Ye, M, Makola, M, Newman, J.A, Fairhead, M, MacLean, E, Krojer, T, Aitkenhead, H, Bountra, C, Gileadi, O, von Delft, F. | Deposit date: | 2022-04-19 | Release date: | 2022-06-22 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.626 Å) | Cite: | Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive crystal contacts To Be Published
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7ZMR
| Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G2*-011 | Descriptor: | ATP-dependent DNA helicase Q5, Gluebody G2*-011, SULFATE ION, ... | Authors: | Ye, M, Makola, M, Newman, J.A, Fairhead, M, MacLean, E, Krojer, T, Aitkenhead, H, Bountra, C, Gileadi, O, von Delft, F. | Deposit date: | 2022-04-19 | Release date: | 2022-06-22 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive crystal contacts To Be Published
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8TTW
| Cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with temsavir, 8ANC195, and 10-1074 | Descriptor: | 1-[4-(benzenecarbonyl)piperazin-1-yl]-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Tolbert, W.D, Pozharski, E, Pazgier, M. | Deposit date: | 2023-08-15 | Release date: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir. Nat Commun, 14, 2023
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6YEA
| Human wtSTING in complex with 2',2'-difluoro-3',3'-cGAMP | Descriptor: | 2',2'-difluoro-3',3'-cGAMP, Stimulator of interferon protein | Authors: | Boura, E, Smola, M. | Deposit date: | 2020-03-24 | Release date: | 2021-03-31 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.805 Å) | Cite: | Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein. Angew.Chem.Int.Ed.Engl., 60, 2021
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7ZMQ
| Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G2*-006 | Descriptor: | ATP-dependent DNA helicase Q5, Gluebody G2*-006, SULFATE ION, ... | Authors: | Ye, M, Makola, M, Newman, J.A, Fairhead, M, MacLean, E, Krojer, T, Aitkenhead, H, Bountra, C, Gileadi, O, von Delft, F. | Deposit date: | 2022-04-19 | Release date: | 2022-06-22 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive crystal contacts To Be Published
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7ZML
| Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G1-001 | Descriptor: | ATP-dependent DNA helicase Q5, Gluebody G1-001, SULFATE ION, ... | Authors: | Ye, M, Makola, M, Newman, J.A, Fairhead, M, MacLean, E, Krojer, T, Aitkenhead, H, Bountra, C, Gileadi, O, von Delft, F. | Deposit date: | 2022-04-19 | Release date: | 2022-06-22 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive crystal contacts To Be Published
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7ZMM
| Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G2-001 | Descriptor: | ATP-dependent DNA helicase Q5, Gluebody G2-001, ZINC ION | Authors: | Ye, M, Makola, M, Newman, J.A, Fairhead, M, MacLean, E, Krojer, T, Aitkenhead, H, Bountra, C, Gileadi, O, von Delft, F. | Deposit date: | 2022-04-19 | Release date: | 2022-06-22 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive crystal contacts To Be Published
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7ZMN
| Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G3-048 | Descriptor: | ATP-dependent DNA helicase Q5, Gluebody G3-048, SULFATE ION, ... | Authors: | Ye, M, Makola, M, Newman, J.A, Fairhead, M, MacLean, E, Krojer, T, Aitkenhead, H, Bountra, C, Gileadi, O, von Delft, F. | Deposit date: | 2022-04-19 | Release date: | 2022-06-22 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive crystal contacts To Be Published
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7QIO
| Homology model of myosin neck domain in skeletal sarcomere | Descriptor: | Myosin light chain 1/3, skeletal muscle isoform, Myosin regulatory light chain 2, ... | Authors: | Wang, Z, Grange, M, Pospich, S, Wagner, T, Kho, A.L, Gautel, M, Raunser, S. | Deposit date: | 2021-12-15 | Release date: | 2022-02-16 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (9 Å) | Cite: | Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin. Science, 375, 2022
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2VF3
| Aquifex aeolicus IspE in complex with ligand | Descriptor: | 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL KINASE, BROMIDE ION, CHLORIDE ION, ... | Authors: | Alphey, M.S, Hunter, W.N. | Deposit date: | 2007-10-30 | Release date: | 2008-11-25 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Inhibitors of the Kinase Ispe: Structure-Activity Relationships and Co-Crystal Structure Analysis. Org.Biomol.Chem., 6, 2008
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3E1Z
| Crystal structure of the parasite protesase inhibitor chagasin in complex with papain | Descriptor: | ACETIC ACID, Chagasin, FORMIC ACID, ... | Authors: | Redzynia, I, Bujacz, G, Bujacz, A, Ljunggren, A, Abrahamson, M, Jaskolski, M. | Deposit date: | 2008-08-05 | Release date: | 2009-01-27 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Crystal structure of the parasite inhibitor chagasin in complex with papain allows identification of structural requirements for broad reactivity and specificity determinants for target proteases. Febs J., 276, 2009
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3DL3
| Crystal structure of the tellurite resistance protein TehB. Northeast Structural Genomics Consortium target VfR98 . | Descriptor: | Tellurite resistance protein B | Authors: | Kuzin, A.P, Su, M, Seetharaman, J, Wang, D, Mao, L, Maglaqui, M, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2008-06-26 | Release date: | 2008-08-26 | Last modified: | 2017-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the tellurite resistance protein TehB. Northeast Structural Genomics Consortium target VfR98. To be Published
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7QIN
| In situ structure of actomyosin complex in skeletal sarcomere | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Wang, Z, Grange, M, Pospich, S, Wagner, T, Kho, A.L, Gautel, M, Raunser, S. | Deposit date: | 2021-12-15 | Release date: | 2022-02-16 | Last modified: | 2022-03-02 | Method: | ELECTRON MICROSCOPY (6.6 Å) | Cite: | Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin. Science, 375, 2022
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3DIB
| Crystal structure of bovine pancreatic ribonuclease A variant (I106A) | Descriptor: | CHLORIDE ION, Ribonuclease pancreatic, SULFATE ION | Authors: | Kurpiewska, K, Font, J, Ribo, M, Vilanova, M, Lewinski, K. | Deposit date: | 2008-06-20 | Release date: | 2008-07-15 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | X-ray crystallographic studies of RNase A variants engineered at the most destabilizing positions of the main hydrophobic core: further insight into protein stability Proteins, 77, 2009
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3DM3
| Crystal structure of a domain of a Replication factor A protein, from Methanocaldococcus jannaschii. NorthEast Structural Genomics target MjR118E | Descriptor: | Replication factor A, SODIUM ION | Authors: | Seetharaman, J, Su, M, Maglaqui, M, Janjua, H, Ciccosanti, C, Xiao, R, Nair, R, Everett, J.K, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2008-06-30 | Release date: | 2008-08-26 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of a domain of a Replication factor A protein, from Methanocaldococcus jannaschii. NorthEast Structural Genomics target MjR118E To be Published
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5KSU
| Crystal structure of HLA-DQ2.5-CLIP1 at 2.73 resolution | Descriptor: | HLA class II histocompatibility antigen gamma chain, HLA class II histocompatibility antigen, DQ alpha 1 chain, ... | Authors: | Nguyen, T.-B, Jayaraman, P, Bergseng, E, Madhusudhan, M.S, Kim, C.-Y, Sollid, L.M. | Deposit date: | 2016-07-10 | Release date: | 2017-04-05 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.73 Å) | Cite: | Unraveling the structural basis for the unusually rich association of human leukocyte antigen DQ2.5 with class-II-associated invariant chain peptides. J. Biol. Chem., 292, 2017
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5KUG
| Human mitochondrial calcium uniporter (residues 72-189) crystal structure with lithium | Descriptor: | Calcium uniporter protein, mitochondrial | Authors: | Mok, M.C.Y, Lee, S.K, Junop, M.S, Stathopulos, P.B. | Deposit date: | 2016-07-13 | Release date: | 2016-09-07 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Insights into Mitochondrial Calcium Uniporter Regulation by Divalent Cations. Cell Chem Biol, 23, 2016
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6Y0D
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6HB4
| TFAM in Complex with Site-Y | Descriptor: | DNA (5'*CP*TP*GP*TP*GP*CP*AP*GP*AP*CP*AP*TP*TP*CP*AP*AP*TP*TP*GP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*CP*AP*AP*TP*TP*GP*AP*AP*TP*GP*TP*CP*TP*GP*CP*AP*CP*AP*G)-3'), GLYCEROL, ... | Authors: | Cuppari, A, Fernandez-Millan, P, Rubio-Cosials, A, Tarres-Sole, A, Lyonnais, S, Sola, M. | Deposit date: | 2018-08-09 | Release date: | 2019-06-05 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | DNA specificities modulate the binding of human transcription factor A to mitochondrial DNA control region. Nucleic Acids Res., 47, 2019
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6YQ5
| Hybrid structure of the SPP1 tail tube by solid-state NMR and cryo EM - NMR Ensemble | Descriptor: | Tail tube protein gp17.1* | Authors: | Zinke, M, Sachowsky, K.A.A, Zinn-Justin, S, Ravelli, R, Schroder, G.F, Habeck, M, Lange, A. | Deposit date: | 2020-04-16 | Release date: | 2020-10-14 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4 Å), SOLID-STATE NMR | Cite: | Architecture of the flexible tail tube of bacteriophage SPP1. Nat Commun, 11, 2020
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7PAY
| Structure of the human heterotetrameric cis-prenyltransferase complex in complex with magnesium and GGsPP | Descriptor: | Dehydrodolichyl diphosphate synthase complex subunit DHDDS, Dehydrodolichyl diphosphate synthase complex subunit NUS1, MAGNESIUM ION, ... | Authors: | Giladi, M, Lisnyansky Bar-El, M, Haitin, Y. | Deposit date: | 2021-07-30 | Release date: | 2022-06-01 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for long-chain isoprenoid synthesis by cis -prenyltransferases. Sci Adv, 8, 2022
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