3BM3
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![BU of 3bm3 by Molmil](/molmil-images/mine/3bm3) | Restriction endonuclease PspGI-substrate DNA complex | 分子名称: | CITRIC ACID, DNA (5'-D(*CP*AP*TP*CP*CP*AP*GP*GP*TP*AP*C)-3'), DNA (5'-D(*GP*GP*TP*AP*CP*CP*TP*GP*GP*AP*T)-3'), ... | 著者 | Szczepanowski, R.H, Carpenter, M, Czapinska, H, Tamulaitis, G, Siksnys, V, Bhagwat, A, Bochtler, M. | 登録日 | 2007-12-12 | 公開日 | 2008-09-16 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | A direct crystallographic demonstration that Type II restriction endonuclease PspGI flips nucleotides To be Published
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6YYN
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![BU of 6yyn by Molmil](/molmil-images/mine/6yyn) | Structure of Cathepsin S in complex with Compound 14 | 分子名称: | CITRATE ANION, Cathepsin S, SULFATE ION, ... | 著者 | Wagener, M, Schade, M, Merla, B, Hars, U, Kueckelhaus, S.Q. | 登録日 | 2020-05-05 | 公開日 | 2021-05-12 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Highly Selective Sub-Nanomolar Cathepsin S Inhibitors by Merging Fragment Binders with Nitrile Inhibitors. J.Med.Chem., 63, 2020
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6QMG
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6BOT
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![BU of 6bot by Molmil](/molmil-images/mine/6bot) | Human APE1 substrate complex with an C/C mismatch adjacent the THF | 分子名称: | 1,2-ETHANEDIOL, 21-mer DNA, DNA-(apurinic or apyrimidinic site) lyase | 著者 | Freudenthal, B.D, Whitaker, A.M, Fairlamb, M.S. | 登録日 | 2017-11-20 | 公開日 | 2018-08-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Apurinic/apyrimidinic (AP) endonuclease 1 processing of AP sites with 5' mismatches. Acta Crystallogr D Struct Biol, 74, 2018
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6YYO
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![BU of 6yyo by Molmil](/molmil-images/mine/6yyo) | Structure of Cathepsin S in complex with Compound 1 | 分子名称: | 1,2-ETHANEDIOL, 6-(4-methylsulfonylpiperazin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine, CITRATE ANION, ... | 著者 | Wagener, M, Schade, M, Merla, B, Hars, U, Kueckelhaus, S.Q. | 登録日 | 2020-05-05 | 公開日 | 2021-05-12 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Highly Selective Sub-Nanomolar Cathepsin S Inhibitors by Merging Fragment Binders with Nitrile Inhibitors. J.Med.Chem., 63, 2020
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6YYP
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![BU of 6yyp by Molmil](/molmil-images/mine/6yyp) | Structure of Cathepsin S in complex with Compound 2 | 分子名称: | 1-(furan-2-ylmethyl)-5-(trifluoromethyl)benzimidazol-2-amine, ACETATE ION, Cathepsin S, ... | 著者 | Wagener, M, Schade, M, Merla, B, Hars, U, Kueckelhaus, S.Q. | 登録日 | 2020-05-05 | 公開日 | 2021-05-12 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Highly Selective Sub-Nanomolar Cathepsin S Inhibitors by Merging Fragment Binders with Nitrile Inhibitors. J.Med.Chem., 63, 2020
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5ZN4
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![BU of 5zn4 by Molmil](/molmil-images/mine/5zn4) | X-ray structure of protein kinase ck2 alpha subunit H148N mutant | 分子名称: | Casein kinase II subunit alpha, SULFATE ION | 著者 | Shibazaki, C, Arai, S, Shimizu, R, Kinoshita, T, Kuroki, R, Adachi, M. | 登録日 | 2018-04-07 | 公開日 | 2018-11-21 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.651 Å) | 主引用文献 | Hydration Structures of the Human Protein Kinase CK2 alpha Clarified by Joint Neutron and X-ray Crystallography. J. Mol. Biol., 430, 2018
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6YYQ
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![BU of 6yyq by Molmil](/molmil-images/mine/6yyq) | Structure of Cathepsin S in complex with Compound 3 | 分子名称: | (6~{R})-2-phenyl-5,6,7,8-tetrahydroquinazolin-6-amine, Cathepsin S | 著者 | Wagener, M, Schade, M, Merla, B, Hars, U, Kueckelhaus, S.Q. | 登録日 | 2020-05-05 | 公開日 | 2021-05-12 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Highly Selective Sub-Nanomolar Cathepsin S Inhibitors by Merging Fragment Binders with Nitrile Inhibitors. J.Med.Chem., 63, 2020
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7XX4
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![BU of 7xx4 by Molmil](/molmil-images/mine/7xx4) | designed glycosyltransferase | 分子名称: | Oleandomycin glycosyltransferase, URIDINE-5'-DIPHOSPHATE-GLUCOSE | 著者 | Lu, M, Wu, X. | 登録日 | 2022-05-28 | 公開日 | 2023-06-14 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Design of a chimeric glycosyltransferase OleD for the site-specific O-monoglycosylation of 3-hydroxypyridine in nosiheptide. Microb Biotechnol, 16, 2023
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6QQL
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![BU of 6qql by Molmil](/molmil-images/mine/6qql) | Crystal structure of Porphyromonas gingivalis glutaminyl cyclase | 分子名称: | Glutamine cyclotransferase, ZINC ION | 著者 | Linnert, M, Piechotta, A, Parthier, C, Taudte, N, Kolenko, P, Rahfeld, J, Potempa, J, Stubbs, M.T. | 登録日 | 2019-02-18 | 公開日 | 2019-03-06 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.814 Å) | 主引用文献 | Mammalian-like type II glutaminyl cyclases in Porphyromonas gingivalis and other oral pathogenic bacteria as targets for treatment of periodontitis. J.Biol.Chem., 296, 2021
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6YYR
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![BU of 6yyr by Molmil](/molmil-images/mine/6yyr) | Structure of Cathepsin S in complex with Compound 20b | 分子名称: | (2~{R})-~{N}-(2-azanylideneethyl)-2-[2-(3-methyl-1,2-oxazol-5-yl)ethanoylamino]-3-(4-pyridin-2-ylpiperazin-1-yl)sulfonyl-propanamide, 1,2-ETHANEDIOL, CITRATE ANION, ... | 著者 | Wagener, M, Schade, M, Merla, B, Hars, U, Kueckelhaus, S.Q. | 登録日 | 2020-05-05 | 公開日 | 2021-05-12 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Highly Selective Sub-Nanomolar Cathepsin S Inhibitors by Merging Fragment Binders with Nitrile Inhibitors. J.Med.Chem., 63, 2020
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6ZHH
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![BU of 6zhh by Molmil](/molmil-images/mine/6zhh) | Ca2+-ATPase from Listeria Monocytogenes with G4 insertion. | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, BERYLLIUM TRIFLUORIDE ION, Calcium-transporting ATPase, ... | 著者 | Basse Hansen, S, Dyla, M, Neumann, C, Quistgaard, E.M.H, Lauwring Andersen, J, Kjaergaard, M, Nissen, P. | 登録日 | 2020-06-23 | 公開日 | 2021-05-19 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The Crystal Structure of the Ca 2+ -ATPase 1 from Listeria monocytogenes reveals a Pump Primed for Dephosphorylation. J.Mol.Biol., 433, 2021
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4PNJ
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![BU of 4pnj by Molmil](/molmil-images/mine/4pnj) | Recombinant Sperm Whale P6 Myoglobin Solved with Single Pulse Free Electron Laser Data | 分子名称: | Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | 著者 | Cohen, A, Gonzalez, A, Lam, W, Lyubimov, A, Sauter, N, Tsai, Y, Uervirojnangkoorn, M, Brunger, A, Soltis, M. | 登録日 | 2014-05-23 | 公開日 | 2014-11-05 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | 主引用文献 | Goniometer-based femtosecond crystallography with X-ray free electron lasers. Proc.Natl.Acad.Sci.USA, 111, 2014
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5HF9
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![BU of 5hf9 by Molmil](/molmil-images/mine/5hf9) | Crystal structure of human acetylcholinesterase in complex with paraoxon and HI6 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Franklin, M.F, Rudolph, M.J, Ginter, C, Cassidy, M.S, Cheung, J. | 登録日 | 2016-01-06 | 公開日 | 2016-06-22 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structures of paraoxon-inhibited human acetylcholinesterase reveal perturbations of the acyl loop and the dimer interface. Proteins, 84, 2016
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6ZHF
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![BU of 6zhf by Molmil](/molmil-images/mine/6zhf) | Calcium ATPase-1 from Listeria monocytogenes in complex with BeF | 分子名称: | BERYLLIUM TRIFLUORIDE ION, Calcium-transporting ATPase, MAGNESIUM ION | 著者 | Basse Hansen, S, Dyla, M, Neumann, C, Quistgaard, E.M.H, Lauwring Andersen, J, Kjaergaard, M, Nissen, P. | 登録日 | 2020-06-23 | 公開日 | 2021-05-19 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (4 Å) | 主引用文献 | The Crystal Structure of the Ca 2+ -ATPase 1 from Listeria monocytogenes reveals a Pump Primed for Dephosphorylation. J.Mol.Biol., 433, 2021
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6ZHG
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![BU of 6zhg by Molmil](/molmil-images/mine/6zhg) | Ca2+-ATPase from Listeria Monocytogenes in complex with AlF | 分子名称: | Calcium-transporting ATPase, MAGNESIUM ION, TETRAFLUOROALUMINATE ION | 著者 | Basse Hansen, S, Dyla, M, Neumann, C, Quistgaard, E.M.H, Lauwring Andersen, J, Kjaergaard, M, Nissen, P. | 登録日 | 2020-06-23 | 公開日 | 2021-05-19 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (4 Å) | 主引用文献 | The Crystal Structure of the Ca 2+ -ATPase 1 from Listeria monocytogenes reveals a Pump Primed for Dephosphorylation. J.Mol.Biol., 433, 2021
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3CU8
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![BU of 3cu8 by Molmil](/molmil-images/mine/3cu8) | Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome | 分子名称: | 14-3-3 protein zeta/delta, MAGNESIUM ION, PROPANOIC ACID, ... | 著者 | Schumacher, B, Weyand, M, Kuhlmann, J, Ottmann, C. | 登録日 | 2008-04-16 | 公開日 | 2009-05-05 | 最終更新日 | 2017-10-25 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol. Cell. Biol., 30, 2010
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5ZN0
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![BU of 5zn0 by Molmil](/molmil-images/mine/5zn0) | Joint X-ray/neutron structure of protein kinase ck2 alpha subunit | 分子名称: | Casein kinase II subunit alpha, SULFATE ION | 著者 | Shibazaki, C, Arai, S, Shimizu, R, Kinoshita, T, Ostermann, A, Schrader, T.E, Sunami, T, Kuroki, R, Adachi, M. | 登録日 | 2018-04-07 | 公開日 | 2018-11-21 | 最終更新日 | 2024-04-03 | 実験手法 | NEUTRON DIFFRACTION (1.1 Å), X-RAY DIFFRACTION | 主引用文献 | Hydration Structures of the Human Protein Kinase CK2 alpha Clarified by Joint Neutron and X-ray Crystallography. J. Mol. Biol., 430, 2018
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6OWJ
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![BU of 6owj by Molmil](/molmil-images/mine/6owj) | Zn-mediated polymerization of human SFPQ | 分子名称: | Splicing factor, proline- and glutamine-rich, ZINC ION | 著者 | Lee, M. | 登録日 | 2019-05-10 | 公開日 | 2020-02-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Structural basis of the zinc-induced cytoplasmic aggregation of the RNA-binding protein SFPQ. Nucleic Acids Res., 48, 2020
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5HNO
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![BU of 5hno by Molmil](/molmil-images/mine/5hno) | The structure of the kdo-capped saccharide binding subunit of the O-12 specific ABC transporter, Wzt | 分子名称: | ABC type transport system putative ATP binding protein, CHLORIDE ION | 著者 | Mallette, E, Mann, E, Whitfield, C, Kimber, M.S. | 登録日 | 2016-01-18 | 公開日 | 2016-03-09 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The Klebsiella pneumoniae O12 ATP-binding Cassette (ABC) Transporter Recognizes the Terminal Residue of Its O-antigen Polysaccharide Substrate. J.Biol.Chem., 291, 2016
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5ZH3
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![BU of 5zh3 by Molmil](/molmil-images/mine/5zh3) | CRYSTAL STRUCTURE OF PfKRS WITH INHIBITOR CLADO-6 | 分子名称: | (3S)-6,8-dihydroxy-3-{[(2R,6R)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, LYSINE, Lysine-tRNA ligase | 著者 | Babbar, P, Malhotra, N, Sharma, M, Harlos, K, Reddy, D.S, Manickam, Y, Sharma, A. | 登録日 | 2018-03-11 | 公開日 | 2018-06-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | 主引用文献 | Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite J. Med. Chem., 61, 2018
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8TFN
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![BU of 8tfn by Molmil](/molmil-images/mine/8tfn) | Structure of anti-TCRvbeta6-5 antibody in complex with the cognate TCR | 分子名称: | Anti-TCRVb6-5 Fab heavy chain, Anti-TCRVb6-5 Fab light chain, TRAV12-3, ... | 著者 | Katragadda, M, Servatalab, R, Wirth, J. | 登録日 | 2023-07-11 | 公開日 | 2023-11-08 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | 主引用文献 | Innate TCR beta-chain engagement drives human T cells toward distinct memory-like effector phenotypes with immunotherapeutic potentials. Sci Adv, 9, 2023
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8TTW
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![BU of 8ttw by Molmil](/molmil-images/mine/8ttw) | Cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with temsavir, 8ANC195, and 10-1074 | 分子名称: | 1-[4-(benzenecarbonyl)piperazin-1-yl]-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Tolbert, W.D, Pozharski, E, Pazgier, M. | 登録日 | 2023-08-15 | 公開日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | 主引用文献 | Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir. Nat Commun, 14, 2023
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6QVV
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![BU of 6qvv by Molmil](/molmil-images/mine/6qvv) | Structure and function of phenuiviridae cap snatching endonucleases | 分子名称: | GLYCEROL, MANGANESE (III) ION, RNA-dependent RNA polymerase, ... | 著者 | Reguera, J, Jones, R, Bragagniolo, G, Lessoued, S, Mate, M. | 登録日 | 2019-03-05 | 公開日 | 2019-09-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure and function of the Toscana virus cap-snatching endonuclease. Nucleic Acids Res., 47, 2019
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6QW0
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![BU of 6qw0 by Molmil](/molmil-images/mine/6qw0) | Structure and function of toscana virus cap snatching endonucleases | 分子名称: | GLYCEROL, MANGANESE (III) ION, RNA-dependent RNA polymerase, ... | 著者 | Reguera, J, Jones, R, Bragagniolo, G, Lessoued, S, Mate, M. | 登録日 | 2019-03-05 | 公開日 | 2019-09-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structure and function of the Toscana virus cap-snatching endonuclease. Nucleic Acids Res., 47, 2019
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