8TFN
Structure of anti-TCRvbeta6-5 antibody in complex with the cognate TCR
Summary for 8TFN
| Entry DOI | 10.2210/pdb8tfn/pdb |
| Descriptor | TRAV12-3, TRBV6-5, Anti-TCRVb6-5 Fab heavy chain, ... (5 entities in total) |
| Functional Keywords | tcr, anti-tcr, trbv12-3, trbv6-5, complex structure, immune system |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 4 |
| Total formula weight | 97122.98 |
| Authors | Katragadda, M.,Servatalab, R.,Wirth, J. (deposition date: 2023-07-11, release date: 2023-11-08, Last modification date: 2024-10-23) |
| Primary citation | Vantourout, P.,Eum, J.,Conde Poole, M.,Hayday, T.S.,Laing, A.G.,Hussain, K.,Nuamah, R.,Kannambath, S.,Moisan, J.,Stoop, A.,Battaglia, S.,Servattalab, R.,Hsu, J.,Bayliffe, A.,Katragadda, M.,Hayday, A.C. Innate TCR beta-chain engagement drives human T cells toward distinct memory-like effector phenotypes with immunotherapeutic potentials. Sci Adv, 9:eadj6174-eadj6174, 2023 Cited by PubMed Abstract: Clonotypic αβ T cell responses to cargoes presented by major histocompatibility complex (MHC), MR1, or CD1 proteins underpin adaptive immunity. Those responses are mostly mediated by complementarity-determining region 3 motifs created by quasi-random T cell receptor (TCR) gene rearrangements, with diversity being highest for TCRγδ. Nonetheless, TCRγδ also displays nonclonotypic innate responsiveness following engagement of germline-encoded Vγ-specific residues by butyrophilin (BTN) or BTN-like (BTNL) proteins that uniquely mediate γδ T cell subset selection. We now report that nonclonotypic TCR engagement likewise induces distinct phenotypes in TCRαβ cells. Specifically, antibodies to germline-encoded human TCRVβ motifs consistently activated naïve or memory T cells toward core states distinct from those induced by anti-CD3 or superantigens and from others commonly reported. Those states combined selective proliferation and effector function with activation-induced inhibitory receptors and memory differentiation. Thus, nonclonotypic TCRVβ targeting broadens our perspectives on human T cell response modes and might offer ways to induce clinically beneficial phenotypes in defined T cell subsets. PubMed: 38055824DOI: 10.1126/sciadv.adj6174 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.54 Å) |
Structure validation
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