5A0A
| Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-[(6R)-5-ethanoyl-4-methyl-2-oxidanylidene-3-[3-(trifluoromethyl)phenyl]-1,6-dihydropyrimidin-6-yl]pyridine-2-carbonitrile, ... | 著者 | vonNussbaum, F, Li, V.M.-J, Allerheiligen, S, Anlauf, S, Baerfacker, L, Bechem, M, Delbeck, M, Fitzgerald, M.F, Gerisch, M, Gielen-Haertwig, H, Haning, H, Karthaus, D, Lang, D, Lustig, K, Meibom, D, Mittendorf, J, Rosentreter, U, Schaefer, M, Schaefer, S, Schamberger, J, Telan, L.A, Tersteegen, A. | 登録日 | 2015-04-17 | 公開日 | 2015-08-19 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem, 10, 2015
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4FIB
| Crystal structure of the ydhK protein from Bacillus subtilis. Northeast Structural Genomics Consortium Target SR518A. | 分子名称: | Uncharacterized protein ydhK | 著者 | Vorobiev, S, Abashidze, M, Seetharaman, J, Mao, M, Xiao, R, Maglaqui, M, Owens, L.A, Cunningham, K, Zhao, L, Everett, J.K, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2012-06-08 | 公開日 | 2012-06-20 | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | 主引用文献 | Crystal structure of the ydhK protein from Bacillus subtilis. To be Published
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6K37
| Crystal structure of BioU (K124A) from Synechocystis sp.PCC6803 in complex with NAD+ and the analog of reaction intermediate, 3-(1-aminoethyl)-nonanedioic acid | 分子名称: | (3R)-3-[(1R)-1-azanylethyl]nonanedioic acid, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Slr0355 protein | 著者 | Sakaki, K, Tomita, T, Nishiyama, M. | 登録日 | 2019-05-16 | 公開日 | 2020-02-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | A suicide enzyme catalyzes multiple reactions for biotin biosynthesis in cyanobacteria. Nat.Chem.Biol., 16, 2020
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4J0K
| Tannin acyl hydrolase in complex with ethyl gallate | 分子名称: | DI(HYDROXYETHYL)ETHER, TETRAETHYLENE GLYCOL, TRIETHYLENE GLYCOL, ... | 著者 | Ren, B, Wu, M, Wang, Q, Peng, X, Wen, H, Chen, Q, McKinstry, W.J. | 登録日 | 2013-01-31 | 公開日 | 2013-05-22 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Crystal structure of tannase from Lactobacillus plantarum. J.Mol.Biol., 425, 2013
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3OGK
| Structure of COI1-ASK1 in complex with coronatine and an incomplete JAZ1 degron | 分子名称: | (1S,2S)-2-ethyl-1-({[(3aS,4S,6R,7aS)-6-ethyl-1-oxooctahydro-1H-inden-4-yl]carbonyl}amino)cyclopropanecarboxylic acid, Coronatine-insensitive protein 1, JAZ1 incomplete degron peptide, ... | 著者 | Sheard, L.B, Tan, X, Mao, H, Withers, J, Ben-Nissan, G, Hinds, T.R, Hsu, F, Sharon, M, Browse, J, He, S.Y, Rizo, J, Howe, G.A, Zheng, N. | 登録日 | 2010-08-16 | 公開日 | 2010-10-13 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor. Nature, 468, 2010
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6GHJ
| PepTSt in complex with tripeptide Phe-Ala-Gln | 分子名称: | (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Martinez Molledo, M, Quistgaard, E.M, Loew, C. | 登録日 | 2018-05-08 | 公開日 | 2018-09-19 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Tripeptide binding in a proton-dependent oligopeptide transporter. FEBS Lett., 592, 2018
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4J4W
| Crystal structure of BueVN | 分子名称: | Nucleocapsid | 著者 | Jiao, L, Ouyang, S, Liang, M, Niu, F, Shaw, N, Wu, W, Ding, W, Jin, C, Zhu, Y, Zhang, F, Wang, T, Li, C, Zuo, X, Luan, C.H, Li, D, Liu, Z.J. | 登録日 | 2013-02-07 | 公開日 | 2013-05-22 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.661 Å) | 主引用文献 | Structure of severe Fever with thrombocytopenia syndrome virus nucleocapsid protein in complex with suramin reveals therapeutic potential J.Virol., 87, 2013
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4OBH
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3OAU
| Antibody 2G12 Recognizes Di-Mannose Equivalently in Domain- and Non-Domain-Exchanged Forms, but only binds the HIV-1 Glycan Shield if Domain-Exchanged | 分子名称: | Fab 2G12, heavy chain, light chain, ... | 著者 | Doores, K.J, Fulton, Z, Huber, M, Wilson, I.A, Burton, D.R. | 登録日 | 2010-08-05 | 公開日 | 2011-01-12 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Antibody 2G12 recognizes di-mannose equivalently in domain- and nondomain-exchanged forms but only binds the HIV-1 glycan shield if domain exchanged. J.Virol., 84, 2010
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4OVX
| Crystal structure of Xylose isomerase domain protein from Planctomyces limnophilus DSM 3776 | 分子名称: | 1,2-ETHANEDIOL, Xylose isomerase domain protein TIM barrel | 著者 | Chang, C, Bigelow, L, Endres, M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2014-01-22 | 公開日 | 2014-02-12 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.253 Å) | 主引用文献 | Crystal structure of Xylose isomerase domain protein from Planctomyces limnophilus DSM 3776 To be published
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6H2V
| Crystal structure of human METTL5-TRMT112 complex, the 18S rRNA m6A1832 methyltransferase at 2.5A resolution | 分子名称: | 1,2-ETHANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, DI(HYDROXYETHYL)ETHER, ... | 著者 | van Tran, N, Graille, M. | 登録日 | 2018-07-16 | 公開日 | 2019-07-31 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112. Nucleic Acids Res., 47, 2019
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4OW4
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4J1X
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4J29
| Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR258. | 分子名称: | Engineered Protein OR258 | 著者 | Vorobiev, S, Su, M, Koga, R, Seetharaman, J, Koga, N, Mao, L, Xiao, R, Kohan, E, Castelllanos, J, Everett, J.K, Acton, T.B, Baker, D, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2013-02-04 | 公開日 | 2013-03-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal Structure of Engineered Protein OR258. To be Published
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6GNY
| Crystal structure of the MAJIN-TERB2 heterotetrameric complex | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Membrane-anchored junction protein, Telomere repeats-binding bouquet formation protein 2 | 著者 | Dunce, J.M, Gurusaran, M, Sen, L.T, Davies, O.R. | 登録日 | 2018-06-01 | 公開日 | 2018-12-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural basis of meiotic telomere attachment to the nuclear envelope by MAJIN-TERB2-TERB1. Nat Commun, 9, 2018
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6GP1
| Structure of mEos4b in the red long-lived dark state | 分子名称: | Green to red photoconvertible GFP-like protein EosFP | 著者 | De Zitter, E, Adam, V, Byrdin, M, Van Meervelt, L, Dedecker, P, Bourgeois, D. | 登録日 | 2018-06-04 | 公開日 | 2019-05-22 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.504 Å) | 主引用文献 | Mechanistic investigation of mEos4b reveals a strategy to reduce track interruptions in sptPALM. Nat.Methods, 16, 2019
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6K6V
| Crystal structure of barley exohydrolaseI W434A mutant in complex with methyl 6-thio-beta-gentiobioside | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, BETA-D-GLUCAN GLUCOHYDROLASE ISOENZYME EXO1, ... | 著者 | Luang, S, Streltsov, V.A, Hrmova, M. | 登録日 | 2019-06-05 | 公開日 | 2020-08-19 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | The evolutionary advantage of an aromatic clamp in plant family 3 glycoside exo-hydrolases. Nat Commun, 13, 2022
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6GP8
| Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112A in complex AMPCPP | 分子名称: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, Heat shock protein HSP 90-alpha, MAGNESIUM ION | 著者 | Tassone, G, Pozzi, C, Mangani, S, Botta, M. | 登録日 | 2018-06-05 | 公開日 | 2018-10-03 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart. Biochim Biophys Acta Proteins Proteom, 1866, 2018
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3CEU
| Crystal structure of thiamine phosphate pyrophosphorylase (BT_0647) from Bacteroides thetaiotaomicron. Northeast Structural Genomics Consortium target BtR268 | 分子名称: | Thiamine phosphate pyrophosphorylase | 著者 | Forouhar, F, Chen, Y, Seetharaman, J, Janjua, H, Mao, L, Xiao, R, Foote, E.L, Maglaqui, M, Ciccosanti, C, Zhao, L, Baran, M.C, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2008-02-29 | 公開日 | 2008-03-25 | 最終更新日 | 2017-10-25 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of thiamine phosphate pyrophosphorylase (BT_0647) from Bacteroides thetaiotaomicron. Northeast Structural Genomics Consortium target BtR268. To be Published
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6K7K
| Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1-ADP-Pi state) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Hiraizumi, M, Yamashita, K, Nishizawa, T, Nureki, O. | 登録日 | 2019-06-07 | 公開日 | 2019-08-28 | 最終更新日 | 2021-02-10 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | Cryo-EM structures capture the transport cycle of the P4-ATPase flippase. Science, 365, 2019
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6K7X
| Human MCU-EMRE complex | 分子名称: | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, CALCIUM ION, CARDIOLIPIN, ... | 著者 | Zhuo, W, Zhou, H, Yang, M. | 登録日 | 2019-06-10 | 公開日 | 2020-09-09 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | Structure of intact human MCU supercomplex with the auxiliary MICU subunits. Protein Cell, 12, 2021
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6GPF
| Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112A in complex with AMPPNP | 分子名称: | Heat shock protein HSP 90-alpha, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Tassone, G, Pozzi, C, Mangani, S, Botta, M. | 登録日 | 2018-06-05 | 公開日 | 2018-10-03 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart. Biochim Biophys Acta Proteins Proteom, 1866, 2018
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3QCX
| Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 6-{2-Amino-6-[(3R)-3-methyl-4-morpholinyl]-4-pyrimidinyl}-1H-indazol-3-amine | 分子名称: | 3-phosphoinositide-dependent protein kinase 1, 6-{2-amino-6-[(3R)-3-methylmorpholin-4-yl]pyrimidin-4-yl}-2H-indazol-3-amine, GLYCEROL, ... | 著者 | Medina, J.R, Becker, C.J, Blackledge, C.W, Duquenne, C, Feng, Y, Grant, S.W, Heerding, D, Li, W.H, Miller, W.H, Romeril, S.P, Scherzer, D, Shu, A, Bobko, M.A, Chadderton, A.R, Dumble, M, Gradiner, C.M, Gilbert, S, Liu, Q, Rabindran, S.K, Sudakin, V, Xiang, H, Brady, P.G, Campobasso, N, Ward, P, Axten, J.M. | 登録日 | 2011-01-17 | 公開日 | 2011-03-09 | 最終更新日 | 2011-11-16 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors. J.Med.Chem., 54, 2011
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6GPO
| Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112A in complex with cAMP | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Heat shock protein HSP 90-alpha, MAGNESIUM ION | 著者 | Tassone, G, Pozzi, C, Mangani, S, Botta, M. | 登録日 | 2018-06-06 | 公開日 | 2018-10-03 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart. Biochim Biophys Acta Proteins Proteom, 1866, 2018
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3CG6
| Crystal structure of Gadd45 gamma | 分子名称: | Growth arrest and DNA-damage-inducible 45 gamma | 著者 | Schrag, J.D, Jiralerspong, S, Banville, M, Jaramillo, M.L, O'Connor-McCourt, M.D. | 登録日 | 2008-03-05 | 公開日 | 2008-04-29 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The crystal structure and dimerization interface of GADD45gamma. Proc.Natl.Acad.Sci.Usa, 105, 2008
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