6SF3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6sf3 by Molmil](/molmil-images/mine/6sf3) | |
7EFI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7efi by Molmil](/molmil-images/mine/7efi) | |
5OCM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ocm by Molmil](/molmil-images/mine/5ocm) | Imine Reductase from Streptosporangium roseum in complex with NADP+ and 2,2,2-trifluoroacetophenone hydrate | 分子名称: | 2,2,2-trifluoromethyl acetophenone hydrate, MAGNESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Sharma, M, Nestl, B, Grogan, G. | 登録日 | 2017-07-03 | 公開日 | 2018-05-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | New imine-reducing enzymes from beta-hydroxyacid dehydrogenases by single amino acid substitutions. Protein Eng. Des. Sel., 31, 2018
|
|
7KX5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7kx5 by Molmil](/molmil-images/mine/7kx5) | Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with noncovalent inhibitor Jun8-76-3A | 分子名称: | 3C-like proteinase, GLYCEROL, N-([1,1'-biphenyl]-4-yl)-N-[(1R)-2-oxo-2-{[(1S)-1-phenylethyl]amino}-1-(pyridin-3-yl)ethyl]furan-2-carboxamide | 著者 | Sacco, M, Wang, J, Chen, Y. | 登録日 | 2020-12-03 | 公開日 | 2020-12-16 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Discovery of Di- and Trihaloacetamides as Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity. J.Am.Chem.Soc., 143, 2021
|
|
6S9Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6s9q by Molmil](/molmil-images/mine/6s9q) | Fragment AZ-004 binding at a primary and secondary site in a p53pT387/14-3-3 complex | 分子名称: | 14-3-3 protein sigma, 4-methyl-5-phenyl-thiophene-2-carboximidamide, CALCIUM ION, ... | 著者 | Leysen, S, Guillory, X, Wolter, M, Genet, S, Somsen, B, Patel, J, Castaldi, P, Ottmann, C. | 登録日 | 2019-07-15 | 公開日 | 2020-06-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
|
|
6SBB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6sbb by Molmil](/molmil-images/mine/6sbb) | Structure of type II terpene cyclase MstE from Scytonema (apo) | 分子名称: | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, ... | 著者 | Moosmann, P, Ecker, F, Leopold-Messer, S, Cahn, J.K.B, Groll, M, Piel, J. | 登録日 | 2019-07-19 | 公開日 | 2020-07-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | A monodomain class II terpene cyclase assembles complex isoprenoid scaffolds. Nat.Chem., 12, 2020
|
|
7EFH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7efh by Molmil](/molmil-images/mine/7efh) | RNA kink-turn motif | 分子名称: | RNA (5'-R(*GP*GP*CP*GP*AP*AP*GP*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') | 著者 | Kondo, J, Nagashima, M. | 登録日 | 2021-03-21 | 公開日 | 2022-03-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | RNA kink-turn motif To Be Published
|
|
6SB2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6sb2 by Molmil](/molmil-images/mine/6sb2) | cryo-EM structure of mTORC1 bound to active RagA/C GTPases | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Ras-related GTP-binding protein A, ... | 著者 | Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L. | 登録日 | 2019-07-18 | 公開日 | 2019-10-16 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (6.2 Å) | 主引用文献 | Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science, 366, 2019
|
|
7EI2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ei2 by Molmil](/molmil-images/mine/7ei2) | Structure of human NNMT in complex with macrocyclic peptide 8 | 分子名称: | Nicotinamide N-methyltransferase, macrocyclic peptide 8 | 著者 | Hayashi, K, Mikamiyama, H, Uehara, S, Yamamoto, S, Cary, D, Nishikawa, J, Ueda, T, Ozasa, H, Mihara, K, Yoshimura, N, Kawai, T, Ono, T, Yamamoto, S, Fumoto, M. | 登録日 | 2021-03-30 | 公開日 | 2022-03-30 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Macrocyclic Peptides as a Novel Class of NNMT Inhibitors: A SAR Study Aimed at Inhibitory Activity in the Cell. Acs Med.Chem.Lett., 12, 2021
|
|
5OFO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ofo by Molmil](/molmil-images/mine/5ofo) | Cryo EM structure of the E. coli disaggregase ClpB (BAP form, DWB mutant), in the ATPgammaS state, bound to the model substrate casein | 分子名称: | Chaperone protein ClpB,ATP-dependent Clp protease ATP-binding subunit ClpA,Chaperone protein ClpB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | 著者 | Deville, C, Carroni, M, Franke, K.B, Topf, M, Bukau, B, Mogk, A, Saibil, H.R. | 登録日 | 2017-07-11 | 公開日 | 2017-08-16 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase. Sci Adv, 3, 2017
|
|
1X58
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1x58 by Molmil](/molmil-images/mine/1x58) | Solution structures of the myb-like DNA binding domain of 4930532D21Rik protein | 分子名称: | Hypothetical protein 4930532D21Rik | 著者 | Nameki, N, Tomizawa, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2005-05-15 | 公開日 | 2005-11-15 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structures of the myb-like DNA binding domain of 4930532D21Rik protein To be Published
|
|
6SF2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6sf2 by Molmil](/molmil-images/mine/6sf2) | Ternary complex of human bone morphogenetic protein 9 (BMP9) growth factor domain, its prodomain and extracellular domain of activin receptor-like kinase 1 (ALK1). | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Growth/differentiation factor 2, Serine/threonine-protein kinase receptor R3 | 著者 | Salmon, R.M, Guo, J, Yu, M, Li, W. | 登録日 | 2019-07-31 | 公開日 | 2020-04-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms. Nat Commun, 11, 2020
|
|
6SHU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6shu by Molmil](/molmil-images/mine/6shu) | Borrelia burgdorferi BmpD nucleoside binding protein bound to adenosine | 分子名称: | ADENOSINE, Basic membrane protein D, CHLORIDE ION, ... | 著者 | Guedez, G, Astrand, M, Cuellar, J, Hytonen, J, Salminen, T.A. | 登録日 | 2019-08-08 | 公開日 | 2020-02-12 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.43002868 Å) | 主引用文献 | Structural and Biomolecular Analyses of Borrelia burgdorferi BmpD Reveal a Substrate-Binding Protein of an ABC-Type Nucleoside Transporter Family. Infect.Immun., 88, 2020
|
|
1TO5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1to5 by Molmil](/molmil-images/mine/1to5) | Structure of the cytosolic Cu,Zn SOD from S. mansoni | 分子名称: | ACETATE ION, COPPER (II) ION, Superoxide dismutase, ... | 著者 | Cardoso, R.M.F, Silva, C.H.T.P, Ulian de Araujo, A.P, Tanaka, T, Tanaka, M, Garratt, R.C. | 登録日 | 2004-06-12 | 公開日 | 2004-08-31 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of the cytosolic Cu,Zn superoxide dismutase from Schistosoma mansoni. Acta Crystallogr.,Sect.D, 60, 2004
|
|
3I4L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3i4l by Molmil](/molmil-images/mine/3i4l) | Structural characterization for the nucleotide binding ability of subunit A with AMP-PNP of the A1AO ATP synthase | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, A-TYPE ATP SYNTHASE CATALYTIC SUBUNIT A, ... | 著者 | Manimekalai, S.M.S, Kumar, A, Balakrishna, A.M, Jeyakanthan, J, Gruber, G. | 登録日 | 2009-07-01 | 公開日 | 2010-01-12 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Nucleotide binding states of subunit A of the A-ATP synthase and the implication of P-loop switch in evolution. J.Mol.Biol., 396, 2010
|
|
6SEV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6sev by Molmil](/molmil-images/mine/6sev) | |
5ON7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5on7 by Molmil](/molmil-images/mine/5on7) | The ENTH domain from epsin-2 in complex with phosphatidylinositol 4,5-bisphosphate (PIP2) | 分子名称: | Epsin-2, SULFATE ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | 著者 | Garcia-Alai, M, GIeras, A, Meijers, R. | 登録日 | 2017-08-03 | 公開日 | 2018-03-07 | 最終更新日 | 2019-10-16 | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | 主引用文献 | Epsin and Sla2 form assemblies through phospholipid interfaces. Nat Commun, 9, 2018
|
|
6SAE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6sae by Molmil](/molmil-images/mine/6sae) | |
7ELK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7elk by Molmil](/molmil-images/mine/7elk) | |
7EFG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7efg by Molmil](/molmil-images/mine/7efg) | RNA kink-turn motif | 分子名称: | RNA (5'-R(*GP*GP*CP*GP*AP*AP*GP*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') | 著者 | Kondo, J, Nagashima, M. | 登録日 | 2021-03-21 | 公開日 | 2022-04-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | RNA kink-turn motif To Be Published
|
|
7EIF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7eif by Molmil](/molmil-images/mine/7eif) | Crystal structure of GAS41 YEATS domain | 分子名称: | GLYCEROL, YEATS domain-containing protein 4 | 著者 | Kikuchi, M, Umehara, T. | 登録日 | 2021-03-30 | 公開日 | 2022-04-06 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
7EKU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7eku by Molmil](/molmil-images/mine/7eku) | |
6SDH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6sdh by Molmil](/molmil-images/mine/6sdh) | Human Carbonic Anhydrase II in complex with an inhibitor soaked at a concentration of 5 mM | 分子名称: | (4-CARBOXYPHENYL)(CHLORO)MERCURY, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... | 著者 | Gloeckner, S, Haake, M, Heine, A, Klebe, G. | 登録日 | 2019-07-27 | 公開日 | 2020-08-26 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.04 Å) | 主引用文献 | Human Carbonic Anhydrase II in complex with an inhibitor soaked at a concentration of 5 mM To Be Published
|
|
7EG5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7eg5 by Molmil](/molmil-images/mine/7eg5) | |
6SEG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6seg by Molmil](/molmil-images/mine/6seg) | Class1: CENP-A nucleosome in complex with CENP-C central region | 分子名称: | DNA (145-MER), Histone H2A type 2-A, Histone H2B type 1-C/E/F/G/I, ... | 著者 | Ali-Ahmad, A, Bilokapic, S, Schafer, I.B, Halic, M, Sekulic, N. | 登録日 | 2019-07-30 | 公開日 | 2019-08-14 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | CENP-C unwraps the human CENP-A nucleosome through the H2A C-terminal tail. Embo Rep., 20, 2019
|
|