164L
 
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5U46
 | | Human PPARdelta ligand-binding domain in complexed with GW501516 | | 分子名称: | DI(HYDROXYETHYL)ETHER, Peroxisome proliferator-activated receptor delta, S-1,2-PROPANEDIOL, ... | | 著者 | Wu, C.-C, Baiga, T.J, Downes, M, La Clair, J.J, Atkins, A.R, Richard, S.B, Stockley-Noel, T.A, Bowman, M.E, Evans, R.M, Noel, J.P. | | 登録日 | 2016-12-03 | | 公開日 | 2017-03-22 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5EMV
 | | Crystal structure of the palmitoylated human TEAD2 transcription factor | | 分子名称: | Transcriptional enhancer factor TEF-4 | | 著者 | Noland, C.L, Gierke, S, Schnier, P.D, Murray, J, Sandoval, W.N, Sagolla, M, Dey, A, Hannoush, R.N, Fairbrother, W.J, Cunningham, C.N. | | 登録日 | 2015-11-06 | | 公開日 | 2015-12-23 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling.
Structure, 24, 2016
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5ENA
 | | Xray crystal structure of isotope-labeled human insulin | | 分子名称: | Insulin chain A, Insulin chain B | | 著者 | Mandal, K, Dhayalan, B, Avital-Shmilovici, M, Tokmakoff, A, Kent, S.B.H. | | 登録日 | 2015-11-09 | | 公開日 | 2016-01-13 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Crystallization of Enantiomerically Pure Proteins from Quasi-Racemic Mixtures: Structure Determination by X-Ray Diffraction of Isotope-Labeled Ester Insulin and Human Insulin.
Chembiochem, 17, 2016
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6GMH
 | | Structure of activated transcription complex Pol II-DSIF-PAF-SPT6 | | 分子名称: | CDC73, CTR9,RNA polymerase-associated protein CTR9 homolog,RNA polymerase-associated protein CTR9 homolog, DNA-directed RNA polymerase II subunit RPB9, ... | | 著者 | Vos, S.M, Farnung, L, Boehing, M, Linden, A, Wigge, C, Urlaub, H, Cramer, P. | | 登録日 | 2018-05-26 | | 公開日 | 2018-08-22 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structure of activated transcription complex Pol II-DSIF-PAF-SPT6.
Nature, 560, 2018
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5H3E
 | | Crystal structure of mouse isocitrate dehydrogenases 2 K256Q mutant complexed with isocitrate | | 分子名称: | ISOCITRIC ACID, Isocitrate dehydrogenase [NADP], mitochondrial, ... | | 著者 | Xu, Y, Liu, L, Miyakawa, T, Nakamura, A, Tanokura, M. | | 登録日 | 2016-10-23 | | 公開日 | 2017-08-30 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Studies on the regulatory mechanism of isocitrate dehydrogenase 2 using acetylation mimics
Sci Rep, 7, 2017
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1A6A
 | | THE STRUCTURE OF AN INTERMEDIATE IN CLASS II MHC MATURATION: CLIP BOUND TO HLA-DR3 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen, DR alpha chain, ... | | 著者 | Ghosh, P, Amaya, M, Mellins, E, Wiley, D.C. | | 登録日 | 1998-02-22 | | 公開日 | 1998-05-27 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3.
Nature, 378, 1995
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1A7Y
 | | CRYSTAL STRUCTURE OF ACTINOMYCIN D | | 分子名称: | ACTINOMYCIN D, ETHYL ACETATE, METHANOL | | 著者 | Schafer, M, Sheldrick, G.M, Bahner, I, Lackner, H. | | 登録日 | 1998-03-19 | | 公開日 | 1999-03-23 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (0.94 Å) | | 主引用文献 | Crystal Structures of Actinomycin D and Actinomycin Z3.
Angew.Chem.Int.Ed.Engl., 37, 1998
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5GTR
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5TSF
 | | Crystal structure of AChBP from Aplysia californica complex with 2-aminopyrimidine at pH 7.0 spacegroup P212121 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-chloro-N~4~,N~4~-bis[(pyridin-3-yl)methyl]pyrimidine-2,4-diamine, Soluble acetylcholine receptor | | 著者 | Camacho-Hernandez, G.A, Kaczanowska, K, Harel, M, Finn, M.G, Taylor, P.W. | | 登録日 | 2016-10-28 | | 公開日 | 2017-10-25 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.286 Å) | | 主引用文献 | Crystal structure of AChBP from Aplysia californica complex with 2-aminopyrimidine at pH 7.0 spacegroup P212121
To Be Published
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5GUC
 | | Crystal structure of CotB2 (apo form) from Streptomyces melanosporofaciens | | 分子名称: | Cyclooctat-9-en-7-ol synthase, FORMIC ACID | | 著者 | Tomita, T, Kim, S.-Y, Ozaki, T, Yoshida, A, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2016-08-28 | | 公開日 | 2017-06-07 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural Insights into the CotB2-Catalyzed Cyclization of Geranylgeranyl Diphosphate to the Diterpene Cyclooctat-9-en-7-ol
ACS Chem. Biol., 12, 2017
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3CI3
 | | Structure of the PduO-type ATP:co(I)rrinoid adenosyltransferase from Lactobacillus reuteri complexed with partial adenosylcobalamin and PPPi | | 分子名称: | 5'-DEOXYADENOSINE, COBALAMIN, Cobalamin adenosyltransferase PduO-like protein, ... | | 著者 | Maurice, M.St, Mera, P.E, Escalante-Semerena, J.C, Rayment, I. | | 登録日 | 2008-03-10 | | 公開日 | 2008-05-27 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.11 Å) | | 主引用文献 | Structural characterization of a human-type corrinoid adenosyltransferase confirms that coenzyme B12 is synthesized through a four-coordinate intermediate.
Biochemistry, 47, 2008
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1AA7
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5TR8
 | | Crystal structure of vaccine-elicited pan- influenza H1N1 neutralizing murine antibody 441D6. | | 分子名称: | 441D6 Fab Heavy chain, 441D6 Fab Light chain, NICKEL (II) ION | | 著者 | Joyce, M.G, Kanekiyo, M, Mascola, J.R, Graham, B.S, Kwong, P.D. | | 登録日 | 2016-10-25 | | 公開日 | 2018-05-09 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses.
Nat.Immunol., 20, 2019
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5GOW
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7RLU
 | | Structure of ALDH1L1 (10-formyltetrahydrofolate dehydrogenase) in complex with NADP | | 分子名称: | 4'-PHOSPHOPANTETHEINE, Cytosolic 10-formyltetrahydrofolate dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Tsybovsky, Y, Sereda, V, Golczak, M, Krupenko, N.I, Krupenko, S.A. | | 登録日 | 2021-07-26 | | 公開日 | 2022-01-12 | | 最終更新日 | 2022-02-02 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structure of putative tumor suppressor ALDH1L1.
Commun Biol, 5, 2022
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5HS3
 | | Human thymidylate synthase complexed with dUMP and 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol, Thymidylate synthase | | 著者 | Chen, D, Almqvist, H, Axelsson, H, Jafari, R, Mateus, A, Haraldsson, M, Larsson, A, Artursson, P, Molina, D.M, Lundback, T, Nordlund, P. | | 登録日 | 2016-01-25 | | 公開日 | 2016-02-24 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.103 Å) | | 主引用文献 | CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
Nat Commun, 7, 2016
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5H3F
 | | Crystal structure of mouse isocitrate dehydrogenases 2 complexed with isocitrate | | 分子名称: | ISOCITRIC ACID, Isocitrate dehydrogenase [NADP], mitochondrial, ... | | 著者 | Xu, Y, Liu, L, Miyakawa, T, Nakamura, A, Tanokura, M. | | 登録日 | 2016-10-23 | | 公開日 | 2017-08-30 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.29 Å) | | 主引用文献 | Studies on the regulatory mechanism of isocitrate dehydrogenase 2 using acetylation mimics
Sci Rep, 7, 2017
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5H6Q
 | | Crystal structure of LSD1-CoREST in complex with peptide 11 | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Lysine-specific histone demethylase 1A, ... | | 著者 | Kikuchi, M, Amano, Y, Sato, S, Yokoyama, S, Umezawa, N, Higuchi, T, Umehara, T. | | 登録日 | 2016-11-14 | | 公開日 | 2017-04-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | | 主引用文献 | Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 1.
Bioorg. Med. Chem., 25, 2017
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1KNO
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7RLT
 | | Structure of ligand-free ALDH1L1 (10-formyltetrahydrofolate dehydrogenase) | | 分子名称: | 4'-PHOSPHOPANTETHEINE, Cytosolic 10-formyltetrahydrofolate dehydrogenase | | 著者 | Tsybovsky, Y, Sereda, V, Golczak, M, Krupenko, N.I, Krupenko, S.A. | | 登録日 | 2021-07-26 | | 公開日 | 2022-01-12 | | 最終更新日 | 2022-02-02 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structure of putative tumor suppressor ALDH1L1.
Commun Biol, 5, 2022
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1KEN
 | | INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH AN ANTIBODY THAT PREVENTS THE HEMAGGLUTININ LOW PH FUSOGENIC TRANSITION | | 分子名称: | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, hemagglutinin HA1, hemagglutinin HA2, ... | | 著者 | Barbey-Martin, C, Gigant, B, Bizebard, T, Calder, L.J, Wharto, S.A, Skehel, J.J, Knossow, M. | | 登録日 | 2001-11-16 | | 公開日 | 2002-04-24 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | An Antibody that Prevents the Hemagglutinin Low pH Fusogenic Transition
VIROLOGY, 294, 2002
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2OKW
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5H7J
 | | Crystal structure of Elongation factor 2 | | 分子名称: | Elongation factor 2, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER | | 著者 | Tanzawa, T, Kato, K, Uchiumi, T, Yao, M. | | 登録日 | 2016-11-18 | | 公開日 | 2018-02-21 | | 最終更新日 | 2018-05-02 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The C-terminal helix of ribosomal P stalk recognizes a hydrophobic groove of elongation factor 2 in a novel fashion
Nucleic Acids Res., 46, 2018
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156L
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