5GTR

estrogen receptor alpha in complex with a stabilized peptide antagonist 6

Summary for 5GTR

Entry DOI	10.2210/pdb5gtr/pdb
Descriptor	Estrogen receptor, ARG-IAS-ILE-0JY-DPP-ARG-0JY-0JY-GLN-NH2, ESTRADIOL (3 entities in total)
Functional Keywords	estrogen receptor alpha, stabilized peptide, transcription
Biological source	Homo sapiens (Human) More
Cellular location	Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372
Total number of polymer chains	2
Total formula weight	29178.50
Authors	Xie, M.,Wang, T.,Li, Z.-G. (deposition date: 2016-08-23, release date: 2017-08-30, Last modification date: 2017-12-20)
Primary citation	Xie, M.,Zhao, H.,Liu, Q.,Zhu, Y.,Yin, F.,Liang, Y.,Jiang, Y.,Wang, D.,Hu, K.,Qin, X.,Wang, Z.,Wu, Y.,Xu, N.,Ye, X.,Wang, T.,Li, Z. Structural Basis of Inhibition of ER alpha-Coactivator Interaction by High-Affinity N-Terminus Isoaspartic Acid Tethered Helical Peptides J. Med. Chem., 60:8731-8740, 2017 Cited by PubMed: 29045135 DOI: 10.1021/acs.jmedchem.7b00732 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.804 Å)

Structure validation