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PDB: 290 件
5S5E
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BU of 5s5e by Molmil
Tubulin-Z1515654336-complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, CALCIUM ION, ...
著者Muehlethaler, T, Gioia, D, Prota, A.E, Sharpe, M.E, Cavalli, A, Steinmetz, M.O.
登録日2020-11-08
公開日2021-06-30
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.67 Å)
主引用文献Comprehensive Analysis of Binding Sites in Tubulin.
Angew.Chem.Int.Ed.Engl., 60, 2021
5S5Z
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BU of 5s5z by Molmil
Tubulin-Z2856434944-complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
著者Muehlethaler, T, Gioia, D, Prota, A.E, Sharpe, M.E, Cavalli, A, Steinmetz, M.O.
登録日2020-11-08
公開日2021-06-30
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Comprehensive Analysis of Binding Sites in Tubulin.
Angew.Chem.Int.Ed.Engl., 60, 2021
5S5A
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BU of 5s5a by Molmil
Tubulin-Z1449748885-complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
著者Muehlethaler, T, Gioia, D, Prota, A.E, Sharpe, M.E, Cavalli, A, Steinmetz, M.O.
登録日2020-11-08
公開日2021-06-30
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Comprehensive Analysis of Binding Sites in Tubulin.
Angew.Chem.Int.Ed.Engl., 60, 2021
5S5F
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BU of 5s5f by Molmil
Tubulin-Z87615031-complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
著者Muehlethaler, T, Gioia, D, Prota, A.E, Sharpe, M.E, Cavalli, A, Steinmetz, M.O.
登録日2020-11-08
公開日2021-06-30
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.24 Å)
主引用文献Comprehensive Analysis of Binding Sites in Tubulin.
Angew.Chem.Int.Ed.Engl., 60, 2021
5S60
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BU of 5s60 by Molmil
Tubulin-Z27695365-complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
著者Muehlethaler, T, Gioia, D, Prota, A.E, Sharpe, M.E, Cavalli, A, Steinmetz, M.O.
登録日2020-11-08
公開日2021-06-30
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Comprehensive Analysis of Binding Sites in Tubulin.
Angew.Chem.Int.Ed.Engl., 60, 2021
5S5H
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BU of 5s5h by Molmil
Tubulin-Z2074076908-complex
分子名称: 1-(5-azaspiro[2.5]octan-5-yl)-2-(difluoromethoxy)ethan-1-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
著者Muehlethaler, T, Gioia, D, Prota, A.E, Sharpe, M.E, Cavalli, A, Steinmetz, M.O.
登録日2020-11-08
公開日2021-06-30
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Comprehensive Analysis of Binding Sites in Tubulin.
Angew.Chem.Int.Ed.Engl., 60, 2021
5S5I
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BU of 5s5i by Molmil
Tubulin-Z295848548-complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]morpholine, CALCIUM ION, ...
著者Muehlethaler, T, Gioia, D, Prota, A.E, Sharpe, M.E, Cavalli, A, Steinmetz, M.O.
登録日2020-11-08
公開日2021-06-30
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Comprehensive Analysis of Binding Sites in Tubulin.
Angew.Chem.Int.Ed.Engl., 60, 2021
5S5J
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BU of 5s5j by Molmil
Tubulin-Z1148747945-complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
著者Muehlethaler, T, Gioia, D, Prota, A.E, Sharpe, M.E, Cavalli, A, Steinmetz, M.O.
登録日2020-11-08
公開日2021-06-30
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Comprehensive Analysis of Binding Sites in Tubulin.
Angew.Chem.Int.Ed.Engl., 60, 2021
5S5M
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BU of 5s5m by Molmil
Tubulin-Z45527714-complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-chloro-N-methylbenzene-1-sulfonamide, CALCIUM ION, ...
著者Muehlethaler, T, Gioia, D, Prota, A.E, Sharpe, M.E, Cavalli, A, Steinmetz, M.O.
登録日2020-11-08
公開日2021-06-30
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Comprehensive Analysis of Binding Sites in Tubulin.
Angew.Chem.Int.Ed.Engl., 60, 2021
5S5N
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BU of 5s5n by Molmil
Tubulin-Z165170770-complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
著者Muehlethaler, T, Gioia, D, Prota, A.E, Sharpe, M.E, Cavalli, A, Steinmetz, M.O.
登録日2020-11-08
公開日2021-06-30
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Comprehensive Analysis of Binding Sites in Tubulin.
Angew.Chem.Int.Ed.Engl., 60, 2021
5SB7
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BU of 5sb7 by Molmil
Tubulin-todalam-18-complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
著者Muehlethaler, T, Milanos, L, Ortega, J.A, Blum, T.B, Gioia, D, Prota, A.E, Cavalli, A, Steinmetz, M.O.
登録日2021-07-08
公開日2022-04-27
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action.
Angew.Chem.Int.Ed.Engl., 61, 2022
5SB6
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BU of 5sb6 by Molmil
Tubulin-todalam-10-complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
著者Muehlethaler, T, Milanos, L, Ortega, J.A, Blum, T.B, Gioia, D, Prota, A.E, Cavalli, A, Steinmetz, M.O.
登録日2021-07-08
公開日2022-04-27
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action.
Angew.Chem.Int.Ed.Engl., 61, 2022
5SB3
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BU of 5sb3 by Molmil
Tubulin-todalam-4-complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
著者Muehlethaler, T, Milanos, L, Ortega, J.A, Blum, T.B, Gioia, D, Prota, A.E, Cavalli, A, Steinmetz, M.O.
登録日2021-07-08
公開日2022-04-27
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action.
Angew.Chem.Int.Ed.Engl., 61, 2022
5SB5
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BU of 5sb5 by Molmil
Tubulin-todalam-9-complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
著者Muehlethaler, T, Milanos, L, Ortega, J.A, Blum, T.B, Gioia, D, Prota, A.E, Cavalli, A, Steinmetz, M.O.
登録日2021-07-08
公開日2022-04-27
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action.
Angew.Chem.Int.Ed.Engl., 61, 2022
5SB4
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BU of 5sb4 by Molmil
Tubulin-todalam-8-complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
著者Muehlethaler, T, Milanos, L, Ortega, J.A, Blum, T.B, Gioia, D, Prota, A.E, Cavalli, A, Steinmetz, M.O.
登録日2021-07-08
公開日2022-04-27
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action.
Angew.Chem.Int.Ed.Engl., 61, 2022
7Z7D
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BU of 7z7d by Molmil
Tubulin-Todalam-Vinblastine-complex
分子名称: (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
著者Muehlethaler, T, Milanos, L, Ortega, J.A, Blum, T.B, Gioia, D, Roy, B, Prota, A.E, Cavalli, A, Steinmetz, M.O.
登録日2022-03-15
公開日2022-04-27
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action.
Angew.Chem.Int.Ed.Engl., 61, 2022
7ZCW
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BU of 7zcw by Molmil
Cryo-EM structure of GMPCPP-microtubules in complex with VASH2-SVBP
分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ...
著者Choi, S.R, Blum, T, Steinmetz, M.O.
登録日2022-03-29
公開日2022-12-14
最終更新日2023-06-28
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献VASH1-SVBP and VASH2-SVBP generate different detyrosination profiles on microtubules.
J.Cell Biol., 222, 2023
8A9T
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BU of 8a9t by Molmil
Tubulin-[1,2]oxazoloisoindole-1 complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
著者Prota, A.E, Abel, A.-C, Steinmetz, M.O, Barraja, P, Montalbano, A, Spano, V.
登録日2022-06-29
公開日2022-11-09
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.304 Å)
主引用文献Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas.
Eur.J.Med.Chem., 243, 2022
8A9Z
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BU of 8a9z by Molmil
Tubulin-[1,2]oxazoloisoindole-2e complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 7-[(3,5-dimethoxyphenyl)methyl]pyrrolo[3,4-g][1,2]benzoxazole, CALCIUM ION, ...
著者Prota, A.E, Abel, A.-C, Steinmetz, M.O, Barraja, P, Montalbano, A, Spano, V.
登録日2022-06-29
公開日2022-11-09
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.294 Å)
主引用文献Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas.
Eur.J.Med.Chem., 243, 2022
8A0L
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BU of 8a0l by Molmil
Tubulin-CW1-complex
分子名称: (3~{S},4~{R},8~{S},10~{S},12~{S},14~{S})-14-[(~{Z},4~{R})-4-(hydroxymethyl)hex-2-en-2-yl]-4,12-dimethoxy-9,9-dimethyl-3,8,10-tris(oxidanyl)-1-oxacyclotetradecan-2-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
著者Prota, A.E, Diaz, J.F, Steinmetz, M.O, Oliva, M.A.
登録日2022-05-28
公開日2022-12-14
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.9981 Å)
主引用文献Chemical modulation of microtubule structure through the laulimalide/peloruside site.
Structure, 31, 2023
7Z2P
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BU of 7z2p by Molmil
Tubulin-nocodazole complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Prota, A.E, Muehlethaler, T, Cavalli, A, Steinmetz, M.O.
登録日2022-02-28
公開日2022-08-31
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents.
Eur.J.Med.Chem., 241, 2022
7Z2N
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BU of 7z2n by Molmil
Tubulin-18-complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
著者Muehlethaler, T, Prota, A.E, Cavalli, A, Steinmetz, M.O.
登録日2022-02-28
公開日2022-08-31
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.17 Å)
主引用文献Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents.
Eur.J.Med.Chem., 241, 2022
3P90
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BU of 3p90 by Molmil
Crystal Structure Analysis of H207F Mutant of Human CLIC1
分子名称: Chloride intracellular channel protein 1
著者Cross, M.O, Fanucchi, S, Achilonu, I.A, Fernandes, M.A, Dirr, H.W.
登録日2010-10-15
公開日2010-11-03
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Role of individual histidines in the pH-dependent global stability of human chloride intracellular channel 1.
Biochemistry, 51, 2012
5M7G
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BU of 5m7g by Molmil
Tubulin-MTD147 complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5-(2,6-dimorpholin-4-ylpyridin-4-yl)-4-(trifluoromethyl)pyridin-2-amine, CALCIUM ION, ...
著者Bohnacker, T, Prota, A.E, Steinmetz, M.O, Wymann, M.P.
登録日2016-10-27
公開日2017-02-22
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.248 Å)
主引用文献Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.
Nat Commun, 8, 2017
5M7E
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BU of 5m7e by Molmil
Tubulin-BKM120 complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5-[2,6-di(morpholin-4-yl)pyrimidin-4-yl]-4-(trifluoromethyl)pyridin-2-amine, CALCIUM ION, ...
著者Bohnacker, T, Prota, A.E, Steinmetz, M.O, Wymann, M.P.
登録日2016-10-27
公開日2017-02-22
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.046 Å)
主引用文献Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.
Nat Commun, 8, 2017

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