5SB4
Tubulin-todalam-8-complex
Summary for 5SB4
Entry DOI | 10.2210/pdb5sb4/pdb |
Group deposition | Todalam compounds complexed with T2R-TTL (G_1002214) |
Descriptor | Tubulin alpha-1B chain, N-{4-[2-(2-fluoroanilino)-1,3-thiazol-4-yl]phenyl}acetamide, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total) |
Functional Keywords | cell cycle, tubulin fold, cytoskeleton, microtubule |
Biological source | Rattus norvegicus (Rat) More |
Total number of polymer chains | 6 |
Total formula weight | 264873.74 |
Authors | Muehlethaler, T.,Milanos, L.,Ortega, J.A.,Blum, T.B.,Gioia, D.,Prota, A.E.,Cavalli, A.,Steinmetz, M.O. (deposition date: 2021-07-08, release date: 2022-04-27, Last modification date: 2022-06-22) |
Primary citation | Muhlethaler, T.,Milanos, L.,Ortega, J.A.,Blum, T.B.,Gioia, D.,Roy, B.,Prota, A.E.,Cavalli, A.,Steinmetz, M.O. Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action. Angew.Chem.Int.Ed.Engl., 61:e202204052-e202204052, 2022 Cited by PubMed: 35404502DOI: 10.1002/anie.202204052 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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