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5SB3

Tubulin-todalam-4-complex

Summary for 5SB3
Entry DOI10.2210/pdb5sb3/pdb
Group depositionTodalam compounds complexed with T2R-TTL (G_1002214)
DescriptorTubulin alpha-1B chain, N-[4-(2-anilino-1,3-thiazol-4-yl)phenyl]acetamide, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
Functional Keywordscell cycle, tubulin fold, cytoskeleton, microtubule
Biological sourceRattus norvegicus (Rat)
More
Total number of polymer chains6
Total formula weight264855.75
Authors
Muehlethaler, T.,Milanos, L.,Ortega, J.A.,Blum, T.B.,Gioia, D.,Prota, A.E.,Cavalli, A.,Steinmetz, M.O. (deposition date: 2021-07-08, release date: 2022-04-27, Last modification date: 2022-06-22)
Primary citationMuhlethaler, T.,Milanos, L.,Ortega, J.A.,Blum, T.B.,Gioia, D.,Roy, B.,Prota, A.E.,Cavalli, A.,Steinmetz, M.O.
Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action.
Angew.Chem.Int.Ed.Engl., 61:e202204052-e202204052, 2022
Cited by
PubMed: 35404502
DOI: 10.1002/anie.202204052
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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