7BWD
| Structure of Dot1L-H2BK34ub Nucleosome Complex | 分子名称: | DNA (146-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | 著者 | Lou, Z.Y, Liu, L, Cao, L, Ai, H.S, Sun, Z.X. | 登録日 | 2020-04-14 | 公開日 | 2021-04-14 | 実験手法 | ELECTRON MICROSCOPY (4.32 Å) | 主引用文献 | Structure of the Dot1L-H2BK34ub Nucleosome Complex Reveals an Unprecedented Crosstalk Activation Mechanism through Nucleosome Shape Distortion To Be Published
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6ADL
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6ADR
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6ADS
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6ADT
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6ADM
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3NGM
| Crystal structure of lipase from Gibberella zeae | 分子名称: | Extracellular lipase | 著者 | Lou, Z.Y, Li, M, Sun, Y.N, Liu, Y, Liu, Z, Rao, Z.H. | 登録日 | 2010-06-12 | 公開日 | 2011-05-25 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of a secreted lipase from Gibberella zeae reveals a novel "double-lock" mechanism Protein Cell, 1, 2010
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6IHB
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6IH9
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3UIM
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3ULX
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3ULZ
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6M5I
| Crystal structure of 2019-nCoV nsp7-nsp8c complex | 分子名称: | Non-structural protein 7, Non-structural protein 8 | 著者 | Yan, L.M, Ge, J, Zhao, Y, Lou, Z.Y, Rao, Z.H. | 登録日 | 2020-03-10 | 公開日 | 2020-06-17 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.496 Å) | 主引用文献 | Crystal structure of 2019-nCoV nsp7-nsp8c complex To Be Published
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7BQ7
| Crystal structure of 2019-nCoV nsp16-nsp10 complex | 分子名称: | 2'-O-methyltransferase, Non-structural protein 10, S-ADENOSYLMETHIONINE, ... | 著者 | Yan, L.M, Huang, Y.C, Lou, Z.Y, Rao, Z.H. | 登録日 | 2020-03-24 | 公開日 | 2020-06-17 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | 主引用文献 | Crystal structure of 2019-nCoV nsp16-nsp10 complex To Be Published
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7EGQ
| Co-transcriptional capping machineries in SARS-CoV-2 RTC: Coupling of N7-methyltransferase and 3'-5' exoribonuclease with polymerase reveals mechanisms for capping and proofreading | 分子名称: | Helicase, MAGNESIUM ION, Non-structural protein 10, ... | 著者 | Yan, L.M, Yang, Y.X, Li, M.Y, Zhang, Y, Zheng, L.T, Ge, J, Huang, Y.C, Liu, Z.Y, Wang, T, Gao, S, Zhang, R, Huang, Y.Y, Guddat, L.W, Gao, Y, Rao, Z.H, Lou, Z.Y. | 登録日 | 2021-03-25 | 公開日 | 2021-07-21 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | 主引用文献 | Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading. Cell, 184, 2021
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7EIZ
| Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading | 分子名称: | Helicase, MAGNESIUM ION, Non-structural protein 10, ... | 著者 | Yan, L, Yang, Y.X, Li, M.Y, Zhang, Y, Zheng, L.T, Ge, J, Huang, Y.C, Liu, Z.Y, Wang, T, Gao, S, Zhang, R, Huang, Y.Y, Guddat, L.W, Gao, Y, Rao, Z.H, Lou, Z.Y. | 登録日 | 2021-04-01 | 公開日 | 2021-09-22 | 最終更新日 | 2023-07-26 | 実験手法 | ELECTRON MICROSCOPY | 主引用文献 | Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading Cell, 184, 2021
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4R3D
| Crystal structure of MERS Coronavirus papain like protease | 分子名称: | Non-structural protein 3, ZINC ION | 著者 | Kong, L.Y, Wang, Q, Ming, Z.H, Shaw, N, Sun, Y.N, Yan, L.M, Lou, Z.Y, Rao, Z.H. | 登録日 | 2014-08-15 | 公開日 | 2015-08-19 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.818 Å) | 主引用文献 | The Crystal Structures of Middle East Respiratory Syndrome Coronavirus Papain-like Protease and Its Complex with an Inhibitor To be Published
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8GWO
| A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors | 分子名称: | Helicase, Non-structural protein 7, Non-structural protein 8, ... | 著者 | Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. | 登録日 | 2022-09-17 | 公開日 | 2022-11-30 | 最終更新日 | 2024-10-30 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
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8GWG
| A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Helicase, Non-structural protein 7, ... | 著者 | Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. | 登録日 | 2022-09-17 | 公開日 | 2022-12-14 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | 主引用文献 | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
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8GWI
| A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Helicase, Non-structural protein 7, ... | 著者 | Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. | 登録日 | 2022-09-17 | 公開日 | 2022-12-14 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | 主引用文献 | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
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8GWN
| A mechanism for SARS-CoV-2 RNA capping and its inhibitor of AT-527 | 分子名称: | Helicase, Non-structural protein 7, Non-structural protein 8, ... | 著者 | Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. | 登録日 | 2022-09-17 | 公開日 | 2022-12-14 | 最終更新日 | 2023-10-25 | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | 主引用文献 | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
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8GWK
| SARS-CoV-2 RNA E-RTC complex with RMP-nsp9 and GMPPNP | 分子名称: | Helicase, MAGNESIUM ION, Non-structural protein 7, ... | 著者 | Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. | 登録日 | 2022-09-17 | 公開日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (2.72 Å) | 主引用文献 | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
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4G3Y
| Crystal structure of TNF-alpha in complex with Infliximab Fab fragment | 分子名称: | Tumor necrosis factor, infliximab Fab H, infliximab Fab L | 著者 | Liang, S.Y, Dai, J.X, Guo, Y.J, Lou, Z.Y. | 登録日 | 2012-07-15 | 公開日 | 2013-03-27 | 最終更新日 | 2024-10-30 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural basis for treating tumor necrosis factor alpha (TNFalpha)-associated diseases with the therapeutic antibody infliximab J.Biol.Chem., 288, 2013
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5GO3
| Crystal structure of a di-nucleotide cyclase Vibrio mutant | 分子名称: | Cyclic GMP-AMP synthase | 著者 | Ming, Z.H, Wang, W, Xie, Y.C, Chen, Y.C, Yan, L.M, Lou, Z.Y. | 登録日 | 2016-07-26 | 公開日 | 2016-11-02 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of a di-nucleotide cyclase Vibrio mutant To Be Published
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5E04
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