5NMT
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![BU of 5nmt by Molmil](/molmil-images/mine/5nmt) | Dimer structure of Sortilin ectodomain crystal form 1, 2.3A | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Leloup, N.O.L, Janssen, B.J.C. | 登録日 | 2017-04-07 | 公開日 | 2017-11-29 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release. Nat Commun, 8, 2017
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5NNJ
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5NMR
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![BU of 5nmr by Molmil](/molmil-images/mine/5nmr) | Monomeric mouse Sortilin extracellular domain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Leloup, N.O.L, Loessl, P, Meijer, D.H.M, Heck, A.J.R, Thies-Weesie, D.M.E, Janssen, B.J.C. | 登録日 | 2017-04-07 | 公開日 | 2017-12-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release. Nat Commun, 8, 2017
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5NNI
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8E1A
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![BU of 8e1a by Molmil](/molmil-images/mine/8e1a) | Structure-based study to overcome cross-reactivity of novel androgen receptor inhibitors | 分子名称: | 1,2-ETHANEDIOL, 4-[4-(3-fluoro-2-methoxyphenyl)-1,3-thiazol-2-yl]morpholine, Androgen receptor | 著者 | Lallous, N, Li, H, Radaeva, M, Dalal, K, Leblanc, E, Ban, F, Ciesielski, F, Chow, B, Morin, M, Singh, K, Rennie, P.S, Cherkasov, A. | 登録日 | 2022-08-10 | 公開日 | 2022-09-14 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Structure-Based Study to Overcome Cross-Reactivity of Novel Androgen Receptor Inhibitors. Cells, 11, 2022
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6FFY
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![BU of 6ffy by Molmil](/molmil-images/mine/6ffy) | Structure of the mouse SorCS2-NGF complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-nerve growth factor, VPS10 domain-containing receptor SorCS2, ... | 著者 | Leloup, N.O.L, Janssen, B.J.C. | 登録日 | 2018-01-09 | 公開日 | 2018-08-01 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | 主引用文献 | Structural insights into SorCS2-Nerve Growth Factor complex formation. Nat Commun, 9, 2018
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6FG9
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6NMX
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6CGQ
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6C8S
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![BU of 6c8s by Molmil](/molmil-images/mine/6c8s) | Loganic acid methyltransferase with SAH | 分子名称: | Loganic acid O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Petronikolou, N, Nair, S.K. | 登録日 | 2018-01-25 | 公開日 | 2018-02-21 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Loganic Acid Methyltransferase: Insights into the Specificity of Methylation on an Iridoid Glycoside. Chembiochem, 19, 2018
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6C8R
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6CHJ
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5F2O
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5F2N
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5F2K
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3ZVZ
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![BU of 3zvz by Molmil](/molmil-images/mine/3zvz) | PHD finger of human UHRF1 | 分子名称: | E3 UBIQUITIN-PROTEIN LIGASE UHRF1, ZINC ION | 著者 | Lallous, N, Birck, C, Mc Ewen, A.G, Legrand, P, Samama, J.P. | 登録日 | 2011-07-28 | 公開日 | 2011-11-30 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.449 Å) | 主引用文献 | The Phd Finger of Human Uhrf1 Reveals a New Subgroup of Unmethylated Histone H3 Tail Readers. Plos One, 6, 2011
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3ZVY
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![BU of 3zvy by Molmil](/molmil-images/mine/3zvy) | PHD finger of human UHRF1 in complex with unmodified histone H3 N- terminal tail | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, E3 UBIQUITIN-PROTEIN LIGASE UHRF1, ... | 著者 | Lallous, N, Birck, C, Mc Ewen, A.G, Legrand, P, Samama, J.P. | 登録日 | 2011-07-28 | 公開日 | 2011-12-07 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | The Phd Finger of Human Uhrf1 Reveals a New Subgroup of Unmethylated Histone H3 Tail Readers. Plos One, 6, 2011
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1O70
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1E7N
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![BU of 1e7n by Molmil](/molmil-images/mine/1e7n) | The N-terminal domain of beta-B2-crystallin resembles the putative ancestral homodimer | 分子名称: | BETA-CRYSTALLIN B2 | 著者 | Clout, N.J, Basak, A, Wieligmann, K, Bateman, O.A, Jaenicke, R, Slingsby, C. | 登録日 | 2000-08-31 | 公開日 | 2000-10-05 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | The N-Terminal Domain of Betab2-Crystallin Resembles the Putative Ancestral Homodimer. J.Mol.Biol., 304, 2000
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1HDF
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![BU of 1hdf by Molmil](/molmil-images/mine/1hdf) | Evolution of the eye lens beta-gamma-crystallin domain fold | 分子名称: | CALCIUM ION, SPHERULIN 3A | 著者 | Clout, N.J, Kretschmar, M, Jaenicke, R, Slingsby, C. | 登録日 | 2000-11-13 | 公開日 | 2000-12-28 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Crystal Structure of the Calcium-Loaded Spherulin 3A Dimer Sheds Light on the Evolution of the Eye Lens Betagamma-Crystallin Domain Fold Structure, 9, 2001
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7W7H
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![BU of 7w7h by Molmil](/molmil-images/mine/7w7h) | S Suis FakA-FakB2 complex structure | 分子名称: | OLEIC ACID, Predicted kinase related to dihydroxyacetone kinase, SULFATE ION, ... | 著者 | Shi, Y, Zang, N, Lou, N, Xu, Y, Sun, J, Huang, M, Zhang, H, Lu, H, Zhou, C, Feng, Y. | 登録日 | 2021-12-04 | 公開日 | 2022-09-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure and mechanism for streptococcal fatty acid kinase (Fak) system dedicated to host fatty acid scavenging. Sci Adv, 8, 2022
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4V88
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![BU of 4v88 by Molmil](/molmil-images/mine/4v88) | The structure of the eukaryotic ribosome at 3.0 A resolution. | 分子名称: | 18S RIBOSOMAL RNA, 18S rRNA, 25S rRNA, ... | 著者 | Ben-Shem, A, Garreau de Loubresse, N, Melnikov, S, Jenner, L, Yusupova, G, Yusupov, M. | 登録日 | 2011-10-11 | 公開日 | 2014-07-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The structure of the eukaryotic ribosome at 3.0 angstrom resolution. Science, 334, 2011
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4V0G
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![BU of 4v0g by Molmil](/molmil-images/mine/4v0g) | JAK3 in complex with a covalent EGFR inhibitor | 分子名称: | N-[3-(2-{3-amino-6-[1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl]pyrazin-2-yl}-1H-benzimidazol-1-yl)phenyl]propanamide, TYROSINE-PROTEIN KINASE JAK3 | 著者 | Debreczeni, J.E, Hennessy, E.J, Chuaquini, C, Ashton, S, Coclough, N, Cross, D.A.E, Eberlein, C, Gingipalli, L, Klinowska, T.C.M, Orme, J.P, Sha, L, Wu, X. | 登録日 | 2014-09-16 | 公開日 | 2016-01-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Utilisation of Structure Based Design to Identify Novel, Irreversible Inhibitors of the Epidermal Growth Factor Receptor (Egfr) Harboring the Gatekeeper T790M Mutation To be Published
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1W8A
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4UIV
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![BU of 4uiv by Molmil](/molmil-images/mine/4uiv) | BROMODOMAIN OF HUMAN BRD9 WITH N-(1,1-dioxo-1-thian-4-yl)-5-methyl-4- oxo-7-3-(trifluoromethyl)phenyl-4H,5H-thieno-3,2-c-pyridine-2- carboximidamide | 分子名称: | 1,2-ETHANEDIOL, BROMODOMAIN-CONTAINING PROTEIN 9, N-(1,1-dioxo-1-thian-4-yl)-5-methyl-4-oxo-7-3-(trifluoromethyl)phenyl-4H,5H-thieno-3,2-c-pyridine-2-carboximidamide | 著者 | Chung, C, Theodoulou, N.T, Bamborough, P, Humphreys, P.G. | 登録日 | 2015-04-03 | 公開日 | 2015-04-22 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | The Discovery of I-Brd9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition. J.Med.Chem., 59, 2016
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