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PDB: 136 results
3T4M
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BU of 3t4m by Molmil
Ac-AChBP ligand binding domain mutated to human alpha-7 nAChR (intermediate)
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Nemecz, A, Taylor, P.W.
Deposit date:2011-07-26
Release date:2011-10-26
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3 Å)
Cite:Creating an alpha-7 nicotinic acetylcholine recognition domain from the acetylcholine binding protein: crystallographic and ligand selectivity analyses
J.Biol.Chem., 286, 2011
3SH1
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BU of 3sh1 by Molmil
Ac-AChBP ligand binding domain mutated to human alpha-7 nAChR
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Nemecz, A, Taylor, P.W.
Deposit date:2011-06-15
Release date:2011-10-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Creating an alpha-7 nicotinic acetylcholine recognition domain from the acetylcholine binding protein: crystallographic and ligand selectivity analyses
J.Biol.Chem., 286, 2011
3C79
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BU of 3c79 by Molmil
Crystal structure of Aplysia californica AChBP in complex with the neonicotinoid imidacloprid
Descriptor: (2E)-1-[(6-chloropyridin-3-yl)methyl]-N-nitroimidazolidin-2-imine, ISOPROPYL ALCOHOL, Soluble acetylcholine receptor
Authors:Talley, T.T, Harel, M, Hibbs, R.E, Tomizawa, M, Casida, J.E, Taylor, P.W.
Deposit date:2008-02-06
Release date:2008-05-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore.
Proc.Natl.Acad.Sci.Usa, 105, 2008
1N5M
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BU of 1n5m by Molmil
Crystal structure of the mouse acetylcholinesterase-gallamine complex
Descriptor: 2,2',2"-[1,2,3-BENZENE-TRIYLTRIS(OXY)]TRIS[N,N,N-TRIETHYLETHANAMINIUM], 2-acetamido-2-deoxy-beta-D-glucopyranose, CARBONATE ION, ...
Authors:Bourne, Y, Taylor, P, Radic, Z, Marchot, P.
Deposit date:2002-11-06
Release date:2003-02-04
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site
EMBO J., 22, 2003
1MAH
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BU of 1mah by Molmil
FASCICULIN2-MOUSE ACETYLCHOLINESTERASE COMPLEX
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE, FASCICULIN 2
Authors:Bourne, Y, Taylor, P, Marchot, P.
Deposit date:1995-11-21
Release date:1996-04-03
Last modified:2021-03-31
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Acetylcholinesterase inhibition by fasciculin: crystal structure of the complex.
Cell(Cambridge,Mass.), 83, 1995
1PXJ
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BU of 1pxj by Molmil
HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-ylamine
Descriptor: 4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2-AMINE, Cell division protein kinase 2
Authors:Wu, S.Y, McNae, I, Kontopidis, G, McClue, S.J, McInnes, C, Stewart, K.J, Wang, S, Zheleva, D.I, Marriage, H, Lane, D.P, Taylor, P, Fischer, P.M, Walkinshaw, M.D.
Deposit date:2003-07-04
Release date:2003-12-09
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop
Structure, 11, 2003
4QAA
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BU of 4qaa by Molmil
X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH 6-(4-Methoxyphenyl)-N4-octylpyrimidine-2,4-diamine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-(4-methoxyphenyl)-N~4~-octylpyrimidine-2,4-diamine, Acetylcholine-binding protein, ...
Authors:Kaczanowska, K, Harel, M, Radic, Z, Changeux, J.-P, Finn, M.G, Taylor, P.
Deposit date:2014-05-03
Release date:2014-07-16
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein.
Proc.Natl.Acad.Sci.USA, 111, 2014
1PXK
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BU of 1pxk by Molmil
HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR N-[4-(2,4-Dimethyl-thiazol-5-yl)pyrimidin-2-yl]-N'-hydroxyiminoformamide
Descriptor: Cell division protein kinase 2, N-[4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2-YL]-N'-HYDROXYIMIDOFORMAMIDE
Authors:Wu, S.Y, McNae, I, Kontopidis, G, McClue, S.J, McInnes, C, Stewart, K.J, Wang, S, Zheleva, D.I, Marriage, H, Lane, D.P, Taylor, P, Fischer, P.M, Walkinshaw, M.D.
Deposit date:2003-07-04
Release date:2003-12-09
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop
Structure, 11, 2003
1PXL
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BU of 1pxl by Molmil
HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR [4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-yl]-(4-trifluoromethyl-phenyl)-amine
Descriptor: 4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)-N-[4-(TRIFLUOROMETHYL)PHENYL]PYRIMIDIN-2-AMINE, Cell division protein kinase 2
Authors:Wu, S.Y, McNae, I, Kontopidis, G, McClue, S.J, McInnes, C, Stewart, K.J, Wang, S, Zheleva, D.I, Marriage, H, Lane, D.P, Taylor, P, Fischer, P.M, Walkinshaw, M.D.
Deposit date:2003-07-04
Release date:2003-12-09
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop
Structure, 11, 2003
3C84
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BU of 3c84 by Molmil
Crystal structure of a complex of AChBP from aplysia californica and the neonicotinoid thiacloprid
Descriptor: ISOPROPYL ALCOHOL, MAGNESIUM ION, Soluble acetylcholine receptor, ...
Authors:Talley, T.T, Harel, M, Hibbs, R.E, Tomizawa, M, Casida, J.E, Taylor, P.W.
Deposit date:2008-02-08
Release date:2008-05-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore.
Proc.Natl.Acad.Sci.Usa, 105, 2008
1PXI
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BU of 1pxi by Molmil
HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 4-(2,5-Dichloro-thiophen-3-yl)-pyrimidin-2-ylamine
Descriptor: 4-(2,5-DICHLOROTHIEN-3-YL)PYRIMIDIN-2-AMINE, Cell division protein kinase 2
Authors:Wu, S.Y, McNae, I, Kontopidis, G, McClue, S.J, McInnes, C, Stewart, K.J, Wang, S, Zheleva, D.I, Marriage, H, Lane, D.P, Taylor, P, Fischer, P.M, Walkinshaw, M.D.
Deposit date:2003-07-04
Release date:2003-12-09
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop
Structure, 11, 2003
1PW2
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BU of 1pw2 by Molmil
APO STRUCTURE OF HUMAN CYCLIN-DEPENDENT KINASE 2
Descriptor: Cell division protein kinase 2
Authors:Wu, S.Y, McNae, I, Kontopidis, G, McClue, S.J, McInnes, C, Stewart, K.J, Wang, S, Zheleva, D.I, Marriage, H, Lane, D.P, Taylor, P, Fischer, P.M, Walkinshaw, M.D.
Deposit date:2003-06-30
Release date:2003-12-09
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop.
Structure, 11, 2003
4QAC
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BU of 4qac by Molmil
X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH 4-(4-methylpiperidin-1-yl)-6-(4-(trifluoromethyl)phenyl)pyrimidin-2-amine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(4-methylpiperidin-1-yl)-6-[4-(trifluoromethyl)phenyl]pyrimidin-2-amine, Acetylcholine-binding protein, ...
Authors:Kaczanowska, K, Harel, M, Radic, Z, Changeux, J.-P, Finn, M.G, Taylor, P.
Deposit date:2014-05-03
Release date:2014-07-16
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein.
Proc.Natl.Acad.Sci.USA, 111, 2014
4QAB
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BU of 4qab by Molmil
X-RAY STRUCTURE of ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH 4-(MORPHOLIN-4-YL)-6-[4-(TRIFLUOROMETHYL)PHENYL]PYRIMIDIN-2-AMINE
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(morpholin-4-yl)-6-[4-(trifluoromethyl)phenyl]pyrimidin-2-amine, Acetylcholine-binding protein, ...
Authors:Kaczanowska, K, Harel, M, Radic, Z, Changeux, J.-P, Finn, M.G, Taylor, P.
Deposit date:2014-05-03
Release date:2014-07-16
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.984 Å)
Cite:Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein.
Proc.Natl.Acad.Sci.USA, 111, 2014
4I89
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BU of 4i89 by Molmil
Crystal structure of transthyretin in complex with diflunisal at acidic pH
Descriptor: 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, Transthyretin
Authors:Zanotti, G, Cendron, L, Folli, C, Florio, P, Imbimbo, B.P, Berni, R.
Deposit date:2012-12-03
Release date:2013-06-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structural evidence for native state stabilization of a conformationally labile amyloidogenic transthyretin variant by fibrillogenesis inhibitors.
Febs Lett., 587, 2013
4I87
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BU of 4i87 by Molmil
Crystal structure of TTR variant I84S in complex with CHF5074 at acidic pH
Descriptor: 1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylic acid, Transthyretin
Authors:Zanotti, G, Cendron, L, Folli, C, Florio, P, Imbimbo, B.P, Berni, R.
Deposit date:2012-12-03
Release date:2013-06-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structural evidence for native state stabilization of a conformationally labile amyloidogenic transthyretin variant by fibrillogenesis inhibitors.
Febs Lett., 587, 2013
3SIO
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BU of 3sio by Molmil
Ac-AChBP ligand binding domain (not including beta 9-10 linker) mutated to human alpha-7 nAChR
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Nemecz, A, Taylor, P.W.
Deposit date:2011-06-19
Release date:2011-10-26
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Creating an alpha-7 nicotinic acetylcholine recognition domain from the acetylcholine binding protein: crystallographic and ligand selectivity analyses
J.Biol.Chem., 286, 2011
1N5R
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BU of 1n5r by Molmil
Crystal structure of the mouse acetylcholinesterase-propidium complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,8-DIAMINO-5[3-(DIETHYLMETHYLAMMONIO)PROPYL]-6-PHENYLPHENANTHRIDINIUM, ACETIC ACID, ...
Authors:Bourne, Y, Taylor, P, Radic, Z, Marchot, P.
Deposit date:2002-11-07
Release date:2003-02-04
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site
EMBO J., 22, 2003
1Q84
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BU of 1q84 by Molmil
Crystal structure of the mouse acetylcholinesterase-TZ2PA6 anti complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,8-DIAMINO-6-PHENYL-5-[6-[1-[2-[(1,2,3,4-TETRAHYDRO-9-ACRIDINYL)AMINO]ETHYL]-1H-1,2,3-TRIAZOL-4-YL]HEXYL]-PHENANTHRIDINIUM, Acetylcholinesterase, ...
Authors:Bourne, Y, Kolb, H.C, Radic, Z, Sharpless, K.B, Taylor, P, Marchot, P.
Deposit date:2003-08-20
Release date:2004-02-10
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation.
Proc.Natl.Acad.Sci.Usa, 101, 2004
1KU6
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BU of 1ku6 by Molmil
Fasciculin 2-Mouse Acetylcholinesterase Complex
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE, ...
Authors:Bourne, Y, Burmeister, W, Taylor, P, Marchot, P.
Deposit date:2002-01-21
Release date:2003-12-23
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site.
EMBO J., 22, 2003
1DYW
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BU of 1dyw by Molmil
Biochemical and structural characterization of a divergent loop cyclophilin from Caenorhabditis elegans
Descriptor: CYCLOPHILIN 3
Authors:Dornan, J, Page, A.P, Taylor, P, Wu, S.Y, Winter, A.D, Husi, H, Walkinshaw, M.D.
Deposit date:2000-02-10
Release date:2000-06-22
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Biochemical and Structural Characterization of a Divergent Loop Cyclophilin from Caenorhabditis Elegans
J.Biol.Chem., 274, 1999
4EZ1
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BU of 4ez1 by Molmil
Crystal structure of acetylcholine binding protein (AChBP) from Aplysia Californica in complex with alpha-conotoxin BuIA
Descriptor: Alpha-conotoxin BuIA, MANGANESE (II) ION, Soluble acetylcholine receptor
Authors:Talley, T.T, Reger, A.S, Kim, C, Sankaran, B, Ho, K, Taylor, P, McIntosh, J.M.
Deposit date:2012-05-02
Release date:2013-05-08
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Pairwise interaction of alpha-conotoxin BuIA Pro6 with the beta subunit of nicotinic acetylcholine receptor
To be Published
1E3B
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BU of 1e3b by Molmil
CYCLOPHILIN 3 FROM C.ELEGANS COMPLEXED WITH AUP(ET)3
Descriptor: CYCLOPHILIN 3, GOLD ION, TRIETHYLPHOSPHANE
Authors:Zou, J, Taylor, P, Dornan, J, Robinson, S.P, Walkinshaw, M.D, Sadler, P.J.
Deposit date:2000-06-08
Release date:2000-10-22
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:First Crystal Structure of a Medicinally Relevant Gold Protein Complex:Unexpected Binding of [Au(Pet (3))](+) to Histidine
Angew.Chem.Int.Ed.Engl., 39, 2000
1Q83
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BU of 1q83 by Molmil
Crystal structure of the mouse acetylcholinesterase-TZ2PA6 syn complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,8-DIAMINO-6-PHENYL-5-[6-[1-[2-[(1,2,3,4-TETRAHYDRO-9-ACRIDINYL)AMINO]ETHYL]-1H-1,2,3-TRIAZOL-5-YL]HEXYL]-PHENANTHRIDINIUM, Acetylcholinesterase, ...
Authors:Bourne, Y, Kolb, H.C, Radic, Z, Sharpless, K.B, Taylor, P, Marchot, P.
Deposit date:2003-08-20
Release date:2004-02-10
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation.
Proc.Natl.Acad.Sci.Usa, 101, 2004
1E8K
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BU of 1e8k by Molmil
Cyclophilin 3 Complexed With Dipeptide Ala-Pro
Descriptor: ALANINE, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE 3, PROLINE
Authors:Wu, S.Y, Dornan, J, Kontopidis, G, Taylor, P, Walkinshaw, M.D.
Deposit date:2000-09-25
Release date:2001-09-20
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The First Direct Determination of a Ligand Binding Constant in Protein Crystals
Angew.Chem.Int.Ed.Engl., 40, 2001

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數據於2024-07-24公開中

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