4AUA
 
 | | Liganded X-ray crystal structure of cyclin dependent kinase 6 (CDK6) | | Descriptor: | 1H-benzimidazol-2-yl(1H-pyrrol-2-yl)methanone, CYCLIN-DEPENDENT KINASE 6 | | Authors: | Cho, Y.S, Angove, H, Brain, C, Chen, C.H.T, Cheng, R, Chopra, R, Chung, K, Congreve, M, Dagostin, C, Davis, D, Feltell, R, Giraldes, J, Hiscock, S, Kim, S, Kovats, S, Lagu, B, Lewry, K, Loo, A, Lu, Y, Luzzio, M, Maniara, W, Mcmenamin, R, Mortenson, P, Benning, R, O'Reilly, M, Rees, D, Shen, J, Smith, T, Wang, Y, Williams, G, Woolford, A, Wrona, W, Xu, M, Yang, F, Howard, S. | | Deposit date: | 2012-05-15 | | Release date: | 2013-02-06 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors.
ACS Med Chem Lett, 3, 2012
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6Q6F
 | | Crystal structure of IDH1 R132H in complex with HMS101 | | Descriptor: | (2~{R})-2-[2-[(3~{R})-3-(4-fluorophenyl)pyrrolidin-1-yl]ethyl]-1,4-dimethyl-piperazine, Isocitrate dehydrogenase [NADP] cytoplasmic | | Authors: | Chaturvedi, A, Goparaju, R, Gupta, C, Kluenemann, T, Araujo Cruz, M.M, Kloos, A, Goerlich, K, Schottmann, R, Struys, E.A, Ganser, A, Preller, M, Heuser, M. | | Deposit date: | 2018-12-10 | | Release date: | 2019-10-16 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site.
Leukemia, 34, 2020
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6UCK
 | | proIAPP in DPC Micelles - Two-Conformer Ensemble Refinement, Bent Conformer | | Descriptor: | Islet amyloid polypeptide | | Authors: | DeLisle, C.F, Malooley, A.L, Banerjee, I, Lorieau, J.L. | | Deposit date: | 2019-09-16 | | Release date: | 2020-02-26 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Pro-islet amyloid polypeptide in micelles contains a helical prohormone segment.
Febs J., 287, 2020
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6UCJ
 | | proIAPP in DPC Micelles - Two-Conformer Ensemble Refinement, Open Conformer | | Descriptor: | Islet amyloid polypeptide | | Authors: | DeLisle, C.F, Malooley, A.L, Banerjee, I, Lorieau, J.L. | | Deposit date: | 2019-09-16 | | Release date: | 2020-02-26 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Pro-islet amyloid polypeptide in micelles contains a helical prohormone segment.
Febs J., 287, 2020
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4S11
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4AFQ
 | | Human Chymase - Fynomer Complex | | Descriptor: | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, CHYMASE, CITRATE ANION, ... | | Authors: | Schlatter, D, Brack, S, Banner, D.W, Batey, S, Benz, J, Bertschinger, J, Huber, W, Joseph, C, Rufer, A, Van Der Kloosters, A, Weber, M, Grabulovski, D, Hennig, M. | | Deposit date: | 2012-01-23 | | Release date: | 2012-07-11 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.51 Å) | | Cite: | Generation, Characterization and Structural Data of Chymase Binding Proteins Based on the Human Fyn Kinase SH3 Domain.
Mabs, 4, 2012
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4AG2
 | | Human Chymase - Fynomer Complex | | Descriptor: | (2S)-2-hydroxybutanedioic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHYMASE, ... | | Authors: | Schlatter, D, Brack, S, Banner, D.W, Batey, S, Benz, J, Bertschinger, J, Huber, W, Joseph, C, Rufer, A, Van Der Kloosters, A, Weber, M, Grabulovski, D, Hennig, M. | | Deposit date: | 2012-01-23 | | Release date: | 2012-07-11 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Generation, Characterization and Structural Data of Chymase Binding Proteins Based on the Human Fyn Kinase SH3 Domain.
Mabs, 4, 2012
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4AFS
 | | Human Chymase - Fynomer Complex | | Descriptor: | CHYMASE, FYNOMER, GLYCEROL, ... | | Authors: | Schlatter, D, Brack, S, Banner, D.W, Batey, S, Benz, J, Bertschinger, J, Huber, W, Joseph, C, Rufer, A, Van Der Kloosters, A, Weber, M, Grabulovski, D, Hennig, M. | | Deposit date: | 2012-01-23 | | Release date: | 2012-07-11 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Generation, Characterization and Structural Data of Chymase Binding Proteins Based on the Human Fyn Kinase SH3 Domain.
Mabs, 4, 2012
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4AFZ
 | | Human Chymase - Fynomer Complex | | Descriptor: | CHYMASE, D(-)-TARTARIC ACID, FYNOMER | | Authors: | Schlatter, D, Brack, S, Banner, D.W, Batey, S, Benz, J, Bertschinger, J, Huber, W, Joseph, C, Rufer, A, Van Der Kloosters, A, Weber, M, Grabulovski, D, Hennig, M. | | Deposit date: | 2012-01-23 | | Release date: | 2012-07-11 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Generation, Characterization and Structural Data of Chymase Binding Proteins Based on the Human Fyn Kinase SH3 Domain.
Mabs, 4, 2012
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4AG1
 | | Human Chymase - Fynomer Complex | | Descriptor: | CHYMASE, FYNOMER, SULFATE ION | | Authors: | Schlatter, D, Brack, S, Banner, D.W, Batey, S, Benz, J, Bertschinger, J, Huber, W, Joseph, C, Rufer, A, Van Der Kloosters, A, Weber, M, Grabulovski, D, Hennig, M. | | Deposit date: | 2012-01-23 | | Release date: | 2012-07-11 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Generation, Characterization and Structural Data of Chymase Binding Proteins Based on the Human Fyn Kinase SH3 Domain.
Mabs, 4, 2012
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4AFU
 | | Human Chymase - Fynomer Complex | | Descriptor: | CHYMASE, FYNOMER | | Authors: | Schlatter, D, Brack, S, Banner, D.W, Batey, S, Benz, J, Bertschinger, J, Huber, W, Joseph, C, Rufer, A, Van Der Kloosters, A, Weber, M, Grabulovski, D, Hennig, M. | | Deposit date: | 2012-01-23 | | Release date: | 2012-07-11 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Generation, Characterization and Structural Data of Chymase Binding Proteins Based on the Human Fyn Kinase SH3 Domain.
Mabs, 4, 2012
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1GAG
 | | CRYSTAL STRUCTURE OF THE INSULIN RECEPTOR KINASE IN COMPLEX WITH A BISUBSTRATE INHIBITOR | | Descriptor: | BISUBSTRATE PEPTIDE INHIBITOR, INSULIN RECEPTOR, TYROSINE KINASE DOMAIN, ... | | Authors: | Parang, K, Till, J.H, Ablooglu, A.J, Kohanski, R.A, Hubbard, S.R, Cole, P.A. | | Deposit date: | 2000-11-29 | | Release date: | 2001-01-17 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Mechanism-based design of a protein kinase inhibitor.
Nat.Struct.Biol., 8, 2001
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1GNH
 | | HUMAN C-REACTIVE PROTEIN | | Descriptor: | C-REACTIVE PROTEIN, CALCIUM ION | | Authors: | Shrive, A.K, Cheetham, G.M.T, Holden, D, Myles, D.A, Turnell, W.G, Volanakis, J.E, Pepys, M.B, Bloomer, A.C, Greenhough, T.J. | | Deposit date: | 1996-03-01 | | Release date: | 1997-01-27 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Three dimensional structure of human C-reactive protein.
Nat.Struct.Biol., 3, 1996
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1QFX
 | | PH 2.5 ACID PHOSPHATASE FROM ASPERGILLUS NIGER | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, PROTEIN (PH 2.5 ACID PHOSPHATASE), ... | | Authors: | Kostrewa, D, Wyss, M, D'Arcy, A, Van Loon, A.P.G.M. | | Deposit date: | 1999-04-15 | | Release date: | 2000-04-19 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of Aspergillus niger pH 2.5 acid phosphatase at 2. 4 A resolution.
J.Mol.Biol., 288, 1999
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1TIM
 | | STRUCTURE OF TRIOSE PHOSPHATE ISOMERASE FROM CHICKEN MUSCLE | | Descriptor: | TRIOSEPHOSPHATE ISOMERASE | | Authors: | Banner, D.W, Bloomer, A.C, Petsko, G.A, Phillips, D.C, Wilson, I.A. | | Deposit date: | 1976-09-01 | | Release date: | 1976-10-15 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Atomic coordinates for triose phosphate isomerase from chicken muscle.
Biochem.Biophys.Res.Commun., 72, 1976
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1I44
 | | CRYSTALLOGRAPHIC STUDIES OF AN ACTIVATION LOOP MUTANT OF THE INSULIN RECEPTOR TYROSINE KINASE | | Descriptor: | INSULIN RECEPTOR, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | | Authors: | Till, J.H, Ablooglu, A.J, Frankel, M, Kohanski, R.A, Hubbard, S.R. | | Deposit date: | 2001-02-19 | | Release date: | 2001-03-07 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism.
J.Biol.Chem., 276, 2001
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3N0I
 | | Crystal Structure of Ad37 fiber knob in complex with GD1a oligosaccharide | | Descriptor: | Fiber, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, ZINC ION | | Authors: | Nilsson, E.C, Storm, R.J, Bauer, J, Johansson, S.M.C, Lookene, A, Angstroem, J, Hedenstroem, M, Fraengsmyr, L, Rinaldi, S, Willison, H, Domelloef, F.P, Stehle, T, Arnberg, N. | | Deposit date: | 2010-05-14 | | Release date: | 2010-12-29 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis.
NAT.MED. (N.Y.), 17, 2011
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1BEY
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1BFO
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1CE1
 | | 1.9A STRUCTURE OF THE THERAPEUTIC ANTIBODY CAMPATH-1H FAB IN COMPLEX WITH A SYNTHETIC PEPTIDE ANTIGEN | | Descriptor: | PROTEIN (CAMPATH-1H:HEAVY CHAIN), PROTEIN (CAMPATH-1H:LIGHT CHAIN), PROTEIN (PEPTIDE ANTIGEN) | | Authors: | James, L.C, Hale, G, Waldmann, H, Bloomer, A.C. | | Deposit date: | 1999-03-12 | | Release date: | 1999-06-25 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | 1.9 A structure of the therapeutic antibody CAMPATH-1H fab in complex with a synthetic peptide antigen.
J.Mol.Biol., 289, 1999
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2FH3
 | | C-terminal half of gelsolin soaked in low calcium at pH 8 | | Descriptor: | CALCIUM ION, Gelsolin | | Authors: | Chumnarnsilpa, S, Loonchanta, A, Xue, B, Choe, H, Urosev, D, Wang, H, Burtnick, L.D, Robinson, R.C. | | Deposit date: | 2005-12-23 | | Release date: | 2006-06-13 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.87 Å) | | Cite: | Calcium ion exchange in crystalline gelsolin
J.Mol.Biol., 357, 2006
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2FH2
 | | C-terminal half of gelsolin soaked in EGTA at pH 4.5 | | Descriptor: | CALCIUM ION, Gelsolin | | Authors: | Chumnarnsilpa, S, Loonchanta, A, Xue, B, Choe, H, Urosev, D, Wang, H, Burtnick, L.D, Robinson, R.C. | | Deposit date: | 2005-12-23 | | Release date: | 2006-06-13 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Calcium ion exchange in crystalline gelsolin
J.Mol.Biol., 357, 2006
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2FH1
 | | C-terminal half of gelsolin soaked in low calcium at pH 4.5 | | Descriptor: | CALCIUM ION, Gelsolin | | Authors: | Chumnarnsilpa, S, Loonchanta, A, Xue, B, Choe, H, Urosev, D, Wang, H, Burtnick, L.D, Robinson, R.C. | | Deposit date: | 2005-12-23 | | Release date: | 2006-06-13 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Calcium ion exchange in crystalline gelsolin
J.Mol.Biol., 357, 2006
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2FH4
 | | C-terminal half of gelsolin soaked in EGTA at pH 8 | | Descriptor: | Gelsolin | | Authors: | Chumnarnsilpa, S, Loonchanta, A, Xue, B, Choe, H, Urosev, D, Wang, H, Burtnick, L.D, Robinson, R.C. | | Deposit date: | 2005-12-23 | | Release date: | 2006-06-13 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Calcium ion exchange in crystalline gelsolin
J.Mol.Biol., 357, 2006
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