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PDB: 32 件
6UOX
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BU of 6uox by Molmil
Structure of itraconazole-bound NPC1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(3-bromo-4-{4-[4-({(2R,4S)-2-(2,4-dichlorophenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]-1,3-dioxolan-4-yl}methoxy)phenyl]piperazin-1-yl}phenyl)-2-[(2S)-butan-2-yl]-2,4-dihydro-3H-1,2,4-triazol-3-one, ...
著者Long, T, Li, X.
登録日2019-10-15
公開日2020-01-15
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (4.13 Å)
主引用文献Structural basis for itraconazole-mediated NPC1 inhibition.
Nat Commun, 11, 2020
6OHU
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BU of 6ohu by Molmil
Structure of EBP and tamoxifen
分子名称: (Z)-2-[4-(1,2)-DIPHENYL-1-BUTENYL)-PHENOXY]-N,N-DIMETHYLETHANAMINE, 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
著者Long, T, Li, X.
登録日2019-04-06
公開日2019-06-19
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (3.526 Å)
主引用文献Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition.
Nat Commun, 10, 2019
6OHT
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BU of 6oht by Molmil
Structure of EBP and U18666A
分子名称: 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase, 3beta-(2-Diethylaminoethoxy)androst-5-en-17-one
著者Long, T, Li, X.
登録日2019-04-06
公開日2019-06-19
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition.
Nat Commun, 10, 2019
8T05
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BU of 8t05 by Molmil
Structure of Ciona Myomaker bound to Fab1A1
分子名称: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1A1 Fab heavy chain, 1A1 Fab light chain, ...
著者Long, T, Li, X.
登録日2023-05-31
公開日2023-09-27
最終更新日2024-02-21
実験手法ELECTRON MICROSCOPY (3.22 Å)
主引用文献Cryo-EM structures of Myomaker reveal a molecular basis for myoblast fusion.
Nat.Struct.Mol.Biol., 30, 2023
8T03
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BU of 8t03 by Molmil
Structure of mouse Myomaker bound to Fab18G7 in detergent
分子名称: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 18G7 Fab heavy chain, 18G7 Fab light chain, ...
著者Long, T, Li, X.
登録日2023-05-31
公開日2023-09-27
最終更新日2023-11-22
実験手法ELECTRON MICROSCOPY (2.72 Å)
主引用文献Cryo-EM structures of Myomaker reveal a molecular basis for myoblast fusion.
Nat.Struct.Mol.Biol., 30, 2023
8T07
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BU of 8t07 by Molmil
Structure of mouse Myomaker mutant-Y118A bound to Fab18G7
分子名称: 18G7 Fab heavy chain, 18G7 Fab light chain, Protein myomaker, ...
著者Long, T, Li, X.
登録日2023-05-31
公開日2023-09-27
最終更新日2023-11-22
実験手法ELECTRON MICROSCOPY (3.38 Å)
主引用文献Cryo-EM structures of Myomaker reveal a molecular basis for myoblast fusion.
Nat.Struct.Mol.Biol., 30, 2023
8T06
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BU of 8t06 by Molmil
Structure of mouse Myomaker mutant-R107A bound to Fab18G7
分子名称: 18G7 Fab heavy chain, 18G7 Fab light chain, Protein myomaker, ...
著者Long, T, Li, X.
登録日2023-05-31
公開日2023-09-27
最終更新日2023-11-22
実験手法ELECTRON MICROSCOPY (3.32 Å)
主引用文献Cryo-EM structures of Myomaker reveal a molecular basis for myoblast fusion.
Nat.Struct.Mol.Biol., 30, 2023
8T04
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BU of 8t04 by Molmil
Structure of mouse Myomaker bound to Fab18G7 in nanodiscs
分子名称: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 18G7 Fab heavy chain, 18G7 Fab light chain, ...
著者Long, T, Li, X.
登録日2023-05-31
公開日2023-09-27
最終更新日2023-11-22
実験手法ELECTRON MICROSCOPY (2.98 Å)
主引用文献Cryo-EM structures of Myomaker reveal a molecular basis for myoblast fusion.
Nat.Struct.Mol.Biol., 30, 2023
6VUM
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BU of 6vum by Molmil
Structure of nevanimibe-bound human tetrameric ACAT1
分子名称: CHOLESTEROL, COENZYME A, OLEIC ACID, ...
著者Li, X, Long, T.
登録日2020-02-16
公開日2020-05-13
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.67 Å)
主引用文献Structure of nevanimibe-bound tetrameric human ACAT1.
Nature, 581, 2020
7R8E
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BU of 7r8e by Molmil
The structure of human ABCG1 E242Q complexed with ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, Isoform 4 of ATP-binding cassette sub-family G member 1, ...
著者Sun, Y, Li, X, Long, T.
登録日2021-06-26
公開日2021-09-08
実験手法ELECTRON MICROSCOPY (3.68 Å)
主引用文献Molecular basis of cholesterol efflux via ABCG subfamily transporters.
Proc.Natl.Acad.Sci.USA, 118, 2021
6XBM
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BU of 6xbm by Molmil
Structure of human SMO-Gi complex with 24(S),25-EC
分子名称: 17-[3-(3,3-DIMETHYL-OXIRANYL)-1-METHYL-PROPYL]-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYC LOPENTA[A]PHENANTHREN-3-OL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Qi, X, Long, T, Li, X.
登録日2020-06-06
公開日2020-09-30
最終更新日2020-11-25
実験手法ELECTRON MICROSCOPY (3.15 Å)
主引用文献Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling.
Nat.Chem.Biol., 16, 2020
6XBK
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BU of 6xbk by Molmil
Structure of human SMO-G111C/I496C complex with Gi
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Qi, X, Long, T, Li, X.
登録日2020-06-06
公開日2020-09-30
最終更新日2020-11-25
実験手法ELECTRON MICROSCOPY (3.24 Å)
主引用文献Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling.
Nat.Chem.Biol., 16, 2020
6XBJ
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BU of 6xbj by Molmil
Structure of human SMO-D384R complex with Gi
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Qi, X, Long, T, Li, X.
登録日2020-06-06
公開日2020-09-30
最終更新日2020-11-25
実験手法ELECTRON MICROSCOPY (3.88 Å)
主引用文献Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling.
Nat.Chem.Biol., 16, 2020
7R8D
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BU of 7r8d by Molmil
The structure of human ABCG1 E242Q with cholesterol
分子名称: CHOLESTEROL, Isoform 4 of ATP-binding cassette sub-family G member 1
著者Sun, Y, Li, X, Long, T.
登録日2021-06-26
公開日2021-09-08
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Molecular basis of cholesterol efflux via ABCG subfamily transporters.
Proc.Natl.Acad.Sci.USA, 118, 2021
7R8A
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BU of 7r8a by Molmil
The structure of human ABCG5/ABCG8 purified from mammalian cells
分子名称: 2C7 Fab heavy chain, 2C7 Fab light chain, ATP-binding cassette sub-family G member 5, ...
著者Sun, Y, Li, X, Long, T.
登録日2021-06-26
公開日2021-09-08
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Molecular basis of cholesterol efflux via ABCG subfamily transporters.
Proc.Natl.Acad.Sci.USA, 118, 2021
7R8B
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BU of 7r8b by Molmil
The structure of human ABCG5/ABCG8 supplemented with cholesterol
分子名称: 2C7 Fab heavy chain, 2C7 Fab light chain, ATP-binding cassette sub-family G member 5, ...
著者Sun, Y, Li, X, Long, T.
登録日2021-06-26
公開日2021-09-08
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Molecular basis of cholesterol efflux via ABCG subfamily transporters.
Proc.Natl.Acad.Sci.USA, 118, 2021
7R88
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BU of 7r88 by Molmil
The structure of human ABCG5-I529W/ABCG8-WT
分子名称: 2C7 Fab heavy chain, 2C7 Fab light chain, ATP-binding cassette sub-family G member 5, ...
著者Sun, Y, Li, X, Long, T.
登録日2021-06-26
公開日2021-09-08
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Molecular basis of cholesterol efflux via ABCG subfamily transporters.
Proc.Natl.Acad.Sci.USA, 118, 2021
7R89
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BU of 7r89 by Molmil
The structure of human ABCG5/ABCG8 purified from yeast
分子名称: 2C7 Fab heavy chain, 2C7 Fab light chain, ATP-binding cassette sub-family G member 5, ...
著者Sun, Y, Li, X, Long, T.
登録日2021-06-26
公開日2021-09-08
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Molecular basis of cholesterol efflux via ABCG subfamily transporters.
Proc.Natl.Acad.Sci.USA, 118, 2021
7R87
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BU of 7r87 by Molmil
The structure of human ABCG5-WT/ABCG8-I419E
分子名称: 2C7 Fab heavy chain, 2C7 Fab light chain, ATP-binding cassette sub-family G member 5, ...
著者Sun, Y, Li, X, Long, T.
登録日2021-06-26
公開日2021-09-08
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Molecular basis of cholesterol efflux via ABCG subfamily transporters.
Proc.Natl.Acad.Sci.USA, 118, 2021
7R8C
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BU of 7r8c by Molmil
The structure of human ABCG1
分子名称: Isoform 4 of ATP-binding cassette sub-family G member 1
著者Sun, Y, Li, X, Long, T.
登録日2021-06-26
公開日2021-09-08
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Molecular basis of cholesterol efflux via ABCG subfamily transporters.
Proc.Natl.Acad.Sci.USA, 118, 2021
7N4U
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BU of 7n4u by Molmil
Structure of human NPC1L1
分子名称: (2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Li, X, Long, T.
登録日2021-06-04
公開日2021-09-01
最終更新日2022-03-16
実験手法ELECTRON MICROSCOPY (3.34 Å)
主引用文献Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption.
Sci Adv, 7, 2021
7N4V
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BU of 7n4v by Molmil
Structure of cholesterol-bound human NPC1L1
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Li, X, Long, T.
登録日2021-06-04
公開日2021-09-01
最終更新日2022-03-16
実験手法ELECTRON MICROSCOPY (3.58 Å)
主引用文献Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption.
Sci Adv, 7, 2021
7N6R
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BU of 7n6r by Molmil
Structure of nevanimibe bound human ACAT2
分子名称: CHOLESTEROL, OLEIC ACID, Sterol O-acyltransferase 2, ...
著者Li, X, Long, T.
登録日2021-06-08
公開日2021-09-15
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.93 Å)
主引用文献Structure of nevanimibe bound human ACAT2
To Be Published
7N6Q
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Structure of PPPA bound human ACAT2
分子名称: (3S,4R,4aR,6S,6aS,12R,12aS,12bS)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-3,6-diyl diacetate, CHOLESTEROL, OLEIC ACID, ...
著者Li, X, Long, T.
登録日2021-06-08
公開日2021-09-22
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.87 Å)
主引用文献Structure of PPPA bound human ACAT2
To Be Published
7N4X
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Structure of human NPC1L1 mutant-W347R
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ...
著者Li, X, Long, T.
登録日2021-06-04
公開日2021-09-01
最終更新日2022-03-16
実験手法ELECTRON MICROSCOPY (3.33 Å)
主引用文献Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption.
Sci Adv, 7, 2021

 

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