1HUX
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![BU of 1hux by Molmil](/molmil-images/mine/1hux) | CRYSTAL STRUCTURE OF THE ACIDAMINOCOCCUS FERMENTANS (R)-2-HYDROXYGLUTARYL-COA DEHYDRATASE COMPONENT A | Descriptor: | ACTIVATOR OF (R)-2-HYDROXYGLUTARYL-COA DEHYDRATASE, ADENOSINE-5'-DIPHOSPHATE, IRON/SULFUR CLUSTER | Authors: | Locher, K.P, Hans, M, Yeh, A.P, Schmid, B, Buckel, W, Rees, D.C. | Deposit date: | 2001-01-04 | Release date: | 2001-03-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of the Acidaminococcus fermentans 2-hydroxyglutaryl-CoA dehydratase component A. J.Mol.Biol., 307, 2001
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1BY5
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![BU of 1by5 by Molmil](/molmil-images/mine/1by5) | FHUA FROM E. COLI, WITH ITS LIGAND FERRICHROME | Descriptor: | FE (III) ION, FERRIC HYDROXAMATE UPTAKE PROTEIN, FERRICHROME, ... | Authors: | Locher, K.P, Rees, B, Koebnik, R, Mitschler, A, Moulinier, L, Rosenbusch, J.P, Moras, D. | Deposit date: | 1998-10-23 | Release date: | 1999-01-13 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Transmembrane signaling across the ligand-gated FhuA receptor: crystal structures of free and ferrichrome-bound states reveal allosteric changes. Cell(Cambridge,Mass.), 95, 1998
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1BY3
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![BU of 1by3 by Molmil](/molmil-images/mine/1by3) | FHUA FROM E. COLI | Descriptor: | N-OCTYL-2-HYDROXYETHYL SULFOXIDE, PROTEIN (FERRICHROME-IRON RECEPTOR PRECURSOR (FHUA)) | Authors: | Locher, K.P, Rees, B, Koebnik, R, Mitschler, A, Moulinier, L, Rosenbusch, J.P, Moras, D. | Deposit date: | 1998-10-22 | Release date: | 1999-01-13 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.74 Å) | Cite: | Transmembrane signaling across the ligand-gated FhuA receptor: crystal structures of free and ferrichrome-bound states reveal allosteric changes. Cell(Cambridge,Mass.), 95, 1998
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1L7V
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![BU of 1l7v by Molmil](/molmil-images/mine/1l7v) | Bacterial ABC Transporter Involved in B12 Uptake | Descriptor: | CYCLO-TETRAMETAVANADATE, VITAMIN B12 TRANSPORT SYSTEM PERMEASE PROTEIN BTUC, Vitamin B12 transport ATP-binding protein btuD | Authors: | Locher, K.P, Lee, A.T, Rees, D.C. | Deposit date: | 2002-03-18 | Release date: | 2002-05-15 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism. Science, 296, 2002
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5OH6
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![BU of 5oh6 by Molmil](/molmil-images/mine/5oh6) | Legionella pneumophila RidL N-terminal domain lacking beta hairpin | Descriptor: | Interaptin | Authors: | Baerlocher, K, Hutter, C.A.J, Swart, A.L, Steiner, B, Welin, A, Hohl, M, Letourneur, F, Seeger, M.A, Hilbi, H. | Deposit date: | 2017-07-14 | Release date: | 2017-11-22 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5. Nat Commun, 8, 2017
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5OH5
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![BU of 5oh5 by Molmil](/molmil-images/mine/5oh5) | Legionella pneumophila RidL N-terminal retromer binding domain | Descriptor: | RidL | Authors: | Baerlocher, K, Hutter, C.A.J, Swart, A.L, Steiner, B, Welin, A, Hohl, M, Letourneur, F, Seeger, M.A, Hilbi, H. | Deposit date: | 2017-07-14 | Release date: | 2017-11-22 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5. Nat Commun, 8, 2017
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1N2Z
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![BU of 1n2z by Molmil](/molmil-images/mine/1n2z) | 2.0 Angstrom structure of BtuF, the vitamin B12 binding protein of E. coli | Descriptor: | CADMIUM ION, CHLORIDE ION, CYANOCOBALAMIN, ... | Authors: | Borths, E.L, Locher, K.P, Lee, A.T, Rees, D.C. | Deposit date: | 2002-10-24 | Release date: | 2002-12-18 | Last modified: | 2021-08-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The structure of Escherichia coli BtuF and binding to its cognate ATP binding cassette transporter Proc.Natl.Acad.Sci.USA, 99, 2002
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4ZRQ
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![BU of 4zrq by Molmil](/molmil-images/mine/4zrq) | |
7ZYI
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![BU of 7zyi by Molmil](/molmil-images/mine/7zyi) | Structure of the human sodium/bile acid cotransporter (NTCP) in complex with Fab and nanobody | Descriptor: | CHOLESTEROL, GLYCOCHENODEOXYCHOLIC ACID, Nanobody, ... | Authors: | Liu, H, Irobalieva, R.N, Bang-Sorensen, R, Nosol, K, Mukherjee, S, Agrawal, P, Stieger, B, Kossiakoff, A.A, Locher, K.P. | Deposit date: | 2022-05-24 | Release date: | 2022-07-13 | Last modified: | 2022-08-10 | Method: | ELECTRON MICROSCOPY (2.88 Å) | Cite: | Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver. Cell Res., 32, 2022
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6EJJ
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![BU of 6ejj by Molmil](/molmil-images/mine/6ejj) | Structure of a glycosyltransferase / state 2 | Descriptor: | 2-acetamido-2-deoxy-alpha-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-alpha-D-glucopyranose, CHLORIDE ION, NerylNeryl pyrophosphate, ... | Authors: | Ramirez, A.S, Boilevin, J, Mehdipour, A.R, Hummer, G, Darbre, T, Reymond, J.L, Locher, K.P. | Deposit date: | 2017-09-21 | Release date: | 2018-02-07 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis of the molecular ruler mechanism of a bacterial glycosyltransferase. Nat Commun, 9, 2018
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3CFX
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![BU of 3cfx by Molmil](/molmil-images/mine/3cfx) | Crystal structure of M. acetivorans periplasmic binding protein ModA/WtpA with bound tungstate | Descriptor: | GLYCEROL, MAGNESIUM ION, TUNGSTATE(VI)ION, ... | Authors: | Comellas-Bigler, M, Hollenstein, K, Locher, K.P. | Deposit date: | 2008-03-04 | Release date: | 2009-03-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Distorted octahedral coordination of tungstate in a subfamily of specific binding proteins. J.Biol.Inorg.Chem., 14, 2009
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7NEZ
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![BU of 7nez by Molmil](/molmil-images/mine/7nez) | Structure of topotecan-bound ABCG2 | Descriptor: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, ... | Authors: | Kowal, J, Locher, K, Ni, D, Stahlberg, H. | Deposit date: | 2021-02-05 | Release date: | 2021-04-21 | Last modified: | 2021-05-12 | Method: | ELECTRON MICROSCOPY (3.39 Å) | Cite: | Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2. J.Mol.Biol., 433, 2021
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7NEQ
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![BU of 7neq by Molmil](/molmil-images/mine/7neq) | Structure of tariquidar-bound ABCG2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ... | Authors: | Kowal, J, Locher, K. | Deposit date: | 2021-02-04 | Release date: | 2021-04-21 | Last modified: | 2021-05-12 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2. J.Mol.Biol., 433, 2021
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7NIV
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![BU of 7niv by Molmil](/molmil-images/mine/7niv) | Nanodisc reconstituted human ABCB4 in complex with 4B1-Fab and QA2-Fab (phosphatidylcholine-bound, occluded conformation) | Descriptor: | 1,2-DILINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 4B1 Fab-fragment light chain, CHOLESTEROL, ... | Authors: | Nosol, K, Locher, K.P. | Deposit date: | 2021-02-14 | Release date: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of ABCB4 provide insight into phosphatidylcholine translocation. Proc.Natl.Acad.Sci.USA, 118, 2021
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7NIU
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3D31
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![BU of 3d31 by Molmil](/molmil-images/mine/3d31) | ModBC from Methanosarcina acetivorans | Descriptor: | Sulfate/molybdate ABC transporter, ATP-binding protein, permease protein, ... | Authors: | Gerber, S, Comellas-Bigler, M, Locher, K.P. | Deposit date: | 2008-05-09 | Release date: | 2008-06-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis of trans-inhibition in a molybdate/tungstate ABC transporter. Science, 321, 2008
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7NFD
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![BU of 7nfd by Molmil](/molmil-images/mine/7nfd) | Structure of mitoxantrone-bound ABCG2 | Descriptor: | 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, ... | Authors: | Kowal, J, Locher, K, Ni, D, Stahlberg, H. | Deposit date: | 2021-02-06 | Release date: | 2021-04-21 | Last modified: | 2021-05-12 | Method: | ELECTRON MICROSCOPY (3.51 Å) | Cite: | Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2. J.Mol.Biol., 433, 2021
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4ZRP
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![BU of 4zrp by Molmil](/molmil-images/mine/4zrp) | TC:CD320 | Descriptor: | CALCIUM ION, CD320 antigen, CYANOCOBALAMIN, ... | Authors: | Alam, A, Locher, K.P. | Deposit date: | 2015-05-12 | Release date: | 2016-07-20 | Last modified: | 2021-08-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis of transcobalamin recognition by human CD320 receptor. Nat Commun, 7, 2016
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7A69
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![BU of 7a69 by Molmil](/molmil-images/mine/7a69) | |
7A6F
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2HYD
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![BU of 2hyd by Molmil](/molmil-images/mine/2hyd) | Multidrug ABC transporter SAV1866 | Descriptor: | ABC transporter homolog, ADENOSINE-5'-DIPHOSPHATE, SODIUM ION | Authors: | Dawson, R.J.P, Locher, K.P. | Deposit date: | 2006-08-05 | Release date: | 2006-09-05 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of a bacterial multidrug ABC transporter. Nature, 443, 2006
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7A6C
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![BU of 7a6c by Molmil](/molmil-images/mine/7a6c) | |
7A6E
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![BU of 7a6e by Molmil](/molmil-images/mine/7a6e) | |
7A65
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![BU of 7a65 by Molmil](/molmil-images/mine/7a65) | |
8PG0
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![BU of 8pg0 by Molmil](/molmil-images/mine/8pg0) | Human OATP1B3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, CHOLESTEROL, ... | Authors: | Ciuta, A.-D, Nosol, K, Kowal, J, Mukherjee, S, Ramirez, A.S, Stieger, B, Kossiakoff, A.A, Locher, K.P. | Deposit date: | 2023-06-17 | Release date: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Structure of human drug transporters OATP1B1 and OATP1B3. Nat Commun, 14, 2023
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