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PDB: 23 件
4XBO
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BU of 4xbo by Molmil
Crystal structure of full length E.coli TrmJ in complex with SAH
分子名称: S-ADENOSYL-L-HOMOCYSTEINE, tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ
著者Liu, R.J, Long, T, Zhou, M, Wang, E.D.
登録日2014-12-17
公開日2015-12-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献tRNA recognition by a bacterial tRNA Xm32 modification enzyme from the SPOUT methyltransferase superfamily
Nucleic Acids Res., 43, 2015
5WWQ
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BU of 5wwq by Molmil
Crystal structure of human NSun6
分子名称: Putative methyltransferase NSUN6
著者Liu, R.J, Long, T, Wang, E.D.
登録日2017-01-04
公開日2017-06-28
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.815 Å)
主引用文献Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6
Nucleic Acids Res., 45, 2017
5WWT
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BU of 5wwt by Molmil
Crystal structure of human NSun6/tRNA
分子名称: Putative methyltransferase NSUN6, tRNA
著者Liu, R.J, Long, T, Wang, E.D.
登録日2017-01-04
公開日2017-06-28
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.197 Å)
主引用文献Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6
Nucleic Acids Res., 45, 2017
5WWS
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BU of 5wws by Molmil
Crystal structure of human NSun6/tRNA/SAM
分子名称: Putative methyltransferase NSUN6, S-ADENOSYLMETHIONINE, tRNA
著者Liu, R.J, Long, T, Wang, E.D.
登録日2017-01-04
公開日2017-06-28
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.247 Å)
主引用文献Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6
Nucleic Acids Res., 45, 2017
5WWR
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BU of 5wwr by Molmil
Crystal structure of human NSun6/tRNA/SFG
分子名称: Putative methyltransferase NSUN6, SINEFUNGIN, tRNA
著者Liu, R.J, Long, T, Wang, E.D.
登録日2017-01-04
公開日2017-06-28
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.096 Å)
主引用文献Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6
Nucleic Acids Res., 45, 2017
4JAL
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BU of 4jal by Molmil
Crystal structure of tRNA (Um34/Cm34) methyltransferase TrmL from Escherichia coli with SAH
分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Liu, R.J, Zhou, M, Wang, E.D.
登録日2013-02-18
公開日2013-07-31
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The tRNA recognition mechanism of the minimalist SPOUT methyltransferase, TrmL
Nucleic Acids Res., 41, 2013
4JAK
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BU of 4jak by Molmil
Crystal structure of tRNA (Um34/Cm34) methyltransferase TrmL from Escherichia coli
分子名称: tRNA (cytidine(34)-2'-O)-methyltransferase
著者Liu, R.J, Zhou, M, Wang, E.D.
登録日2013-02-18
公開日2013-07-31
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The tRNA recognition mechanism of the minimalist SPOUT methyltransferase, TrmL
Nucleic Acids Res., 41, 2013
3PZ6
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BU of 3pz6 by Molmil
The crystal structure of GlLeuRS-CP1
分子名称: Leucyl-tRNA synthetase
著者Liu, R.J, Du, D.H, Wang, E.D.
登録日2010-12-14
公開日2011-08-24
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Peripheral insertion modulates the editing activity of the isolated CP1 domain of leucyl-tRNA synthetase
Biochem.J., 440, 2011
3PZ5
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BU of 3pz5 by Molmil
The crystal structure of AaLeuRS-CP1-D20
分子名称: Leucyl-tRNA synthetase subunit alpha
著者Liu, R.J, Wang, E.D.
登録日2010-12-14
公開日2011-08-24
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Peripheral insertion modulates the editing activity of the isolated CP1 domain of leucyl-tRNA synthetase
Biochem.J., 440, 2011
3PZ0
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BU of 3pz0 by Molmil
The crystal structure of AaLeuRS-CP1
分子名称: CALCIUM ION, Leucyl-tRNA synthetase subunit alpha
著者Liu, R.J, Wang, E.D.
登録日2010-12-13
公開日2011-08-24
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Peripheral insertion modulates the editing activity of the isolated CP1 domain of leucyl-tRNA synthetase
Biochem.J., 440, 2011
7BZJ
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BU of 7bzj by Molmil
The Discovery of Benzhydrol-Oxaborole Hybrid Derivatives as Leucyl-tRNA Synthetase Inhibitors
分子名称: Leucine--tRNA ligase, [(1~{R},5~{R},6~{S},8~{R})-8-(6-aminopurin-9-yl)-4'-[(~{R})-oxidanyl-[4-(2-oxidanylidenepropylsulfanyl)phenyl]methyl]spiro[2,4,7-trioxa-3-boranuidabicyclo[3.3.0]octane-3,7'-7-boranuidabicyclo[4.3.0]nona-1(6),2,4-triene]-6-yl]methoxy-tris(oxidanyl)phosphanium
著者Liu, R.J, Li, H, Wang, E.D, Zhou, H.
登録日2020-04-28
公開日2020-12-09
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery of benzhydrol-oxaborole derivatives as Streptococcus pneumoniae leucyl-tRNA synthetase inhibitors.
Bioorg.Med.Chem., 29, 2021
6LR6
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BU of 6lr6 by Molmil
The crystal structure of human cytoplasmic LRS
分子名称: 4-Chloro-3-aminomethyl-7-[ethoxy]-3H-benzo[C][1,2]oxaborol-1-ol modified adenosine, 5'-O-(L-leucylsulfamoyl)adenosine, Leucine--tRNA ligase, ...
著者Liu, R.J, Long, T, Li, H, Li, J, Zhao, J.H, Lin, J.Z, Palencia, A, Wang, M.Z, Cusack, S, Wang, E.D.
登録日2020-01-15
公開日2020-03-25
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.009 Å)
主引用文献Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond.
Nucleic Acids Res., 48, 2020
6LPF
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BU of 6lpf by Molmil
The crystal structure of human cytoplasmic LRS
分子名称: 2'-(L-NORVALYL)AMINO-2'-DEOXYADENOSINE, 5'-O-(L-leucylsulfamoyl)adenosine, GLYCEROL, ...
著者Liu, R.J, Long, T, Li, H, Li, J, Zhao, J.H, Lin, J.Z, Palencia, A, Wang, M.Z, Cusack, S, Wang, E.D.
登録日2020-01-10
公開日2020-03-25
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond.
Nucleic Acids Res., 48, 2020
5FOL
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BU of 5fol by Molmil
Crystal structure of the Cryptosporidium muris cytosolic leucyl-tRNA synthetase editing domain complex with a post-transfer editing analogue of isoeucine (Ile2AA)
分子名称: 2'-(L-ISOLEUCYL)AMINO-2'-DEOXYADENOSINE, LEUCYL-TRNA SYNTHETASE, PHOSPHATE ION
著者Palencia, A, Liu, R.J, Lukarska, M, Gut, J, Bougdour, A, Touquet, B, Wang, E.D, Alley, M.R.K, Rosenthal, P.J, Hakimi, M.A, Cusack, S.
登録日2015-11-24
公開日2016-08-03
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5FOM
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BU of 5fom by Molmil
Crystal structure of the Cryptosporidium muris cytosolic leucyl-tRNA synthetase editing domain complex with the adduct AMP-AN6426
分子名称: 4-Chloro-3-aminomethyl-7-[ethoxy]-3H-benzo[C][1,2]oxaborol-1-ol modified adenosine, LEUCYL-TRNA SYNTHETASE, PHOSPHATE ION
著者Palencia, A, Liu, R.J, Lukarska, M, Gut, J, Bougdour, A, Touquet, B, Wang, E.D, Alley, M.R.K, Rosenthal, P.J, Hakimi, M.A, Cusack, S.
登録日2015-11-24
公開日2016-08-03
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5FOG
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BU of 5fog by Molmil
Crystal structure of hte Cryptosporidium muris cytosolic leucyl-tRNA synthetase editing domain complex with a post-transfer editing analogue of norvaline (Nv2AA)
分子名称: 1,2-ETHANEDIOL, 2'-(L-NORVALYL)AMINO-2'-DEOXYADENOSINE, LEUCYL-TRNA SYNTHETASE, ...
著者Palencia, A, Liu, R.J, Lukarska, M, Gut, J, Bougdour, A, Touquet, B, Wang, E.D, Alley, M.R.K, Rosenthal, P.J, Hakimi, M.A, Cusack, S.
登録日2015-11-20
公開日2016-08-03
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5FON
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BU of 5fon by Molmil
Crystal structure of the Cryptosporidium muris cytosolic leucyl-tRNA synthetase editing domain (apo structure)
分子名称: LEUCYL-TRNA SYNTHETASE
著者Palencia, A, Liu, R.J, Lukarska, M, Gut, J, Bougdour, A, Touquet, B, Wang, E.D, Alley, M.R.K, Rosenthal, P.J, Hakimi, M.A, Cusack, S.
登録日2015-11-24
公開日2016-08-03
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
4K48
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BU of 4k48 by Molmil
Structure of the Streptococcus pneumoniae leucyl-tRNA synthetase editing domain
分子名称: Leucine--tRNA ligase
著者Hu, Q.H, Liu, R.J, Fang, Z.P, Zhang, J, Ding, Y.Y, Tan, M, Wang, M, Pan, W, Zhou, H.C, Wang, E.D.
登録日2013-04-12
公開日2013-09-04
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase
Sci Rep, 3, 2013
4K47
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BU of 4k47 by Molmil
Structure of the Streptococcus pneumoniae leucyl-tRNA synthetase editing domain bound to a benzoxaborole-AMP adduct
分子名称: Leucine--tRNA ligase, SULFATE ION, [(1R,5R,6R,8S)-6-(6-aminopurin-9-yl)-3'-[(R)-oxidanyl(phenyl)methyl]spiro[2,4,7-trioxa-3-boranuidabicyclo[3.3.0]octane-3,9'-8-oxa-9-boranuidabicyclo[4.3.0]nona-1,3,5-triene]-8-yl]methyl dihydrogen phosphate
著者Hu, Q.H, Liu, R.J, Fang, Z.P, Zhang, J, Ding, Y.Y, Tan, M, Wang, M, Pan, W, Zhou, H.C, Wang, E.D.
登録日2013-04-12
公開日2013-09-04
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase
Sci Rep, 3, 2013
5ZVE
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BU of 5zve by Molmil
The crystal structure of NSun6 from Pyrococcus horikoshii with SAH
分子名称: 389aa long hypothetical nucleolar protein, S-ADENOSYL-L-HOMOCYSTEINE
著者Li, J, Liu, R.J, Wang, E.D.
登録日2018-05-10
公開日2018-12-12
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.178 Å)
主引用文献Archaeal NSUN6 catalyzes m5C72 modification on a wide-range of specific tRNAs.
Nucleic Acids Res., 47, 2019
5ZVH
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BU of 5zvh by Molmil
The crystal structure of NSun6 from Pyrococcus horikoshii with SFG
分子名称: 389aa long hypothetical nucleolar protein, SINEFUNGIN
著者Li, J, Liu, R.J, Wang, E.D.
登録日2018-05-10
公開日2018-12-12
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Archaeal NSUN6 catalyzes m5C72 modification on a wide-range of specific tRNAs.
Nucleic Acids Res., 47, 2019
5ZVD
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BU of 5zvd by Molmil
The crystal structure of NSun6 from Pyrococcus horikoshii
分子名称: 389aa long hypothetical nucleolar protein
著者Li, J, Liu, R.J, Wang, E.D.
登録日2018-05-10
公開日2018-12-12
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.594 Å)
主引用文献Archaeal NSUN6 catalyzes m5C72 modification on a wide-range of specific tRNAs.
Nucleic Acids Res., 47, 2019
5ZVG
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BU of 5zvg by Molmil
The crystal structure of NSun6 from Pyrococcus horikoshii with SAM
分子名称: 389aa long hypothetical nucleolar protein, S-ADENOSYLMETHIONINE
著者Li, J, Liu, R.J, Wang, E.D.
登録日2018-05-10
公開日2018-12-12
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Archaeal NSUN6 catalyzes m5C72 modification on a wide-range of specific tRNAs.
Nucleic Acids Res., 47, 2019

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