4K48

Structure of the Streptococcus pneumoniae leucyl-tRNA synthetase editing domain

Summary for 4K48

Entry DOI	10.2210/pdb4k48/pdb
Related	4K47
Descriptor	Leucine--tRNA ligase (2 entities in total)
Functional Keywords	leucyl-trna synthetase, benzoxaboroles, antibacterial, ligase
Biological source	Streptococcus pneumoniae
Cellular location	Cytoplasm (By similarity): B8ZKS5
Total number of polymer chains	1
Total formula weight	21091.47
Authors	Hu, Q.H.,Liu, R.J.,Fang, Z.P.,Zhang, J.,Ding, Y.Y.,Tan, M.,Wang, M.,Pan, W.,Zhou, H.C.,Wang, E.D. (deposition date: 2013-04-12, release date: 2013-09-04, Last modification date: 2023-11-08)
Primary citation	Hu, Q.H.,Liu, R.J.,Fang, Z.P.,Zhang, J.,Ding, Y.Y.,Tan, M.,Wang, M.,Pan, W.,Zhou, H.C.,Wang, E.D. Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase Sci Rep, 3:2475-2475, 2013 Cited by PubMed: 23959225 DOI: 10.1038/srep02475 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.49 Å)

Structure validation