1BL3
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![BU of 1bl3 by Molmil](/molmil-images/mine/1bl3) | CATALYTIC DOMAIN OF HIV-1 INTEGRASE | Descriptor: | INTEGRASE, MAGNESIUM ION | Authors: | Maignan, S, Guilloteau, J.P, Zhou-Liu, Q, Clement-Mella, C, Mikol, V. | Deposit date: | 1998-07-23 | Release date: | 1998-09-30 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases. J.Mol.Biol., 282, 1998
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1BI4
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![BU of 1bi4 by Molmil](/molmil-images/mine/1bi4) | CATALYTIC DOMAIN OF HIV-1 INTEGRASE | Descriptor: | INTEGRASE | Authors: | Maignan, S, Guilloteau, J.P, Zhou-Liu, Q, Clement-Mella, C, Mikol, V. | Deposit date: | 1998-06-22 | Release date: | 1998-11-04 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases. J.Mol.Biol., 282, 1998
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7TDO
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![BU of 7tdo by Molmil](/molmil-images/mine/7tdo) | Cryo-EM structure of transmembrane AAA+ protease FtsH in the ADP state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent zinc metalloprotease FtsH | Authors: | Liu, W, Schoonen, M, Wang, T, McSweeney, S, Liu, Q. | Deposit date: | 2022-01-02 | Release date: | 2022-04-06 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Cryo-EM structure of transmembrane AAA+ protease FtsH in the ADP state. Commun Biol, 5, 2022
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5IFG
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![BU of 5ifg by Molmil](/molmil-images/mine/5ifg) | Crystal structure of HigA-HigB complex from E. Coli | Descriptor: | Antitoxin HigA, mRNA interferase HigB | Authors: | Yang, J.S, Zhou, K, Gao, z.Q, Liu, Q.S, Dong, Y.H. | Deposit date: | 2016-02-26 | Release date: | 2017-03-01 | Method: | X-RAY DIFFRACTION (2.702 Å) | Cite: | Structural insight into the E. coli HigBA complex Biochem. Biophys. Res. Commun., 478, 2016
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4JNF
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![BU of 4jnf by Molmil](/molmil-images/mine/4jnf) | Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP | Descriptor: | Hsp70 CHAPERONE DnaK | Authors: | Qi, R, Sarbeng, E.B, Liu, Q, Le, K.Q, Xu, X, Xu, H, Yang, J, Wong, J.L, Vorvis, C, Hendrickson, W.A, Zhou, L, Liu, Q. | Deposit date: | 2013-03-15 | Release date: | 2013-05-29 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.621 Å) | Cite: | Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP. Nat.Struct.Mol.Biol., 20, 2013
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5K0X
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![BU of 5k0x by Molmil](/molmil-images/mine/5k0x) | Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC2541 | Descriptor: | (7S)-7-amino-N-[(4-fluorophenyl)methyl]-8-oxo-2,9,16,18,21-pentaazabicyclo[15.3.1]henicosa-1(21),17,19-triene-20-carboxamide, CHLORIDE ION, Tyrosine-protein kinase Mer | Authors: | McIver, A.L, Zhang, W, Liu, Q, Jiang, X, Stashko, M.A, Nichols, J, Miley, M.J, Norris-Drouin, J, Machius, M, DeRyckere, D, Wood, E, Graham, D.K, Earp, H.S, Kireev, D, Frye, S.V, Wang, X. | Deposit date: | 2016-05-17 | Release date: | 2017-02-22 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.231 Å) | Cite: | Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors. ChemMedChem, 12, 2017
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5NBT
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![BU of 5nbt by Molmil](/molmil-images/mine/5nbt) | Apo structure of p60N/p80C katanin | Descriptor: | Katanin p60 ATPase-containing subunit A1, Katanin p80 WD40 repeat-containing subunit B1 | Authors: | Jiang, K, Rezabkova, L, Hua, S, Liu, Q, Capitani, G, Altelaar, A.F.M, Heck, A.J.R, Kammerer, R.A, Steinmetz, M.O, Akhmanova, A. | Deposit date: | 2017-03-02 | Release date: | 2017-04-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex. Nat. Cell Biol., 19, 2017
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3I9O
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![BU of 3i9o by Molmil](/molmil-images/mine/3i9o) | Crystal structure of ADP ribosyl cyclase complexed with ribo-2'F-ADP ribose | Descriptor: | ADP-ribosyl cyclase, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4S)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate | Authors: | Graeff, R, Liu, Q, Kriksunov, I.A, Kotaka, M, Oppenheimer, N, Hao, Q, Lee, H.C. | Deposit date: | 2009-07-12 | Release date: | 2009-07-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Mechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38 J.Biol.Chem., 284, 2009
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6VN7
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![BU of 6vn7 by Molmil](/molmil-images/mine/6vn7) | Cryo-EM structure of an activated VIP1 receptor-G protein complex | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Duan, J, Shen, D.-D, Zhou, X.E, Liu, Q.-F, Zhuang, Y.-W, Zhang, H.-B, Xu, P.-Y, Ma, S.-S, He, X.-H, Melcher, K, Zhang, Y, Xu, H.E, Yi, J. | Deposit date: | 2020-01-29 | Release date: | 2020-09-02 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy. Nat Commun, 11, 2020
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1Y00
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![BU of 1y00 by Molmil](/molmil-images/mine/1y00) | Solution structure of the Carbon Storage Regulator protein CsrA | Descriptor: | Carbon storage regulator | Authors: | Gutierrez, P, Li, Y, Osborne, M.J, Liu, Q, Gehring, K, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | Deposit date: | 2004-11-13 | Release date: | 2005-06-21 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of the carbon storage regulator protein CsrA from Escherichia coli. J.Bacteriol., 187, 2005
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7SEV
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![BU of 7sev by Molmil](/molmil-images/mine/7sev) | Crystal structure of E coli contaminant protein YadF co-purified with a plant protein | Descriptor: | Carbonic anhydrase 2, POTASSIUM ION, ZINC ION | Authors: | Chai, L, Zhu, P, Chai, J, Pang, C, Andi, B, McsWeeney, S, Shanklin, J, Liu, Q. | Deposit date: | 2021-10-01 | Release date: | 2021-11-03 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | AlphaFold Protein Structure Database for Sequence-Independent Molecular Replacement Crystals, 11, 2021
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4IQ8
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![BU of 4iq8 by Molmil](/molmil-images/mine/4iq8) | Crystal structure of glyceraldehyde-3-phosphate dehydrogenase 3 from Saccharomyces cerevisiae | Descriptor: | Glyceraldehyde-3-phosphate dehydrogenase 3 | Authors: | Wang, H, Liu, Q, Niu, L, Teng, M, Li, X. | Deposit date: | 2013-01-11 | Release date: | 2013-02-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Preliminary crystallographic analysis of glyceraldehyde-3-phosphate dehydrogenase 3 from Saccharomyces cerevisiae. Acta Crystallogr.,Sect.F, 68, 2012
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6PBR
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![BU of 6pbr by Molmil](/molmil-images/mine/6pbr) | Catalytic domain of E.coli dihydrolipoamide succinyltransferase in I4 space group | Descriptor: | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, SODIUM ION | Authors: | Andi, B, Soares, A.S, Shi, W, Fuchs, M.R, McSweeney, S, Liu, Q. | Deposit date: | 2019-06-14 | Release date: | 2019-06-26 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of the dihydrolipoamide succinyltransferase catalytic domain from Escherichia coli in a novel crystal form: a tale of a common protein crystallization contaminant. Acta Crystallogr.,Sect.F, 75, 2019
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7V3R
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![BU of 7v3r by Molmil](/molmil-images/mine/7v3r) | Crystal structure of CMET in complex with a novel inhibitor | Descriptor: | Hepatocyte growth factor receptor, ~{N}1'-[3-fluoranyl-4-(2-phenylazanylpyrimidin-4-yl)oxy-phenyl]-~{N}1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Authors: | Su, H.X, Liu, Q.F, Chen, T.T, Li, M.J, Xu, Y.C. | Deposit date: | 2021-08-11 | Release date: | 2022-08-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Discovery of 10H-Benzo[b]pyrido[2,3-e][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase J.Med.Chem., 66, 2023
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7V3S
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![BU of 7v3s by Molmil](/molmil-images/mine/7v3s) | Crystal structure of CMET in complex with a novel inhibitor | Descriptor: | Hepatocyte growth factor receptor, ~{N}1'-[3-fluoranyl-4-(10~{H}-pyrido[3,2-b][1,4]benzoxazin-4-yloxy)phenyl]-~{N}1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Authors: | Su, H.X, Liu, Q.F, Chen, T.T, Li, M.J, Xu, Y.C. | Deposit date: | 2021-08-11 | Release date: | 2022-08-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Discovery of 10H-Benzo[b]pyrido[2,3-e][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase J.Med.Chem., 66, 2023
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6O8A
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![BU of 6o8a by Molmil](/molmil-images/mine/6o8a) | Thaumatin native-SAD structure determined at 5 keV from microcrystals | Descriptor: | L(+)-TARTARIC ACID, Thaumatin-1 | Authors: | Guo, G, Zhu, P, Fuchs, M.R, Shi, W, Andi, B, Gao, Y, Hendrickson, W.A, McSweeney, S, Liu, Q. | Deposit date: | 2019-03-09 | Release date: | 2019-05-08 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Synchrotron microcrystal native-SAD phasing at a low energy. Iucrj, 6, 2019
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6NQ9
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![BU of 6nq9 by Molmil](/molmil-images/mine/6nq9) | |
2INF
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![BU of 2inf by Molmil](/molmil-images/mine/2inf) | Crystal Structure of Uroporphyrinogen Decarboxylase from Bacillus subtilis | Descriptor: | Uroporphyrinogen decarboxylase | Authors: | Fan, J, Liu, Q, Hao, Q, Teng, M.K, Niu, L.W. | Deposit date: | 2006-10-06 | Release date: | 2006-10-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of uroporphyrinogen decarboxylase from Bacillus subtilis J.Bacteriol., 189, 2007
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6NQ7
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![BU of 6nq7 by Molmil](/molmil-images/mine/6nq7) | |
6NQ8
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![BU of 6nq8 by Molmil](/molmil-images/mine/6nq8) | |
3UAF
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![BU of 3uaf by Molmil](/molmil-images/mine/3uaf) | Crystal Structure of a TTR-52 mutant of C. elegans | Descriptor: | TTR-52 | Authors: | Kang, Y.Y, Zhao, D.F, Liang, H.H, Liu, B, Liu, Q.W, Wang, X.C, Liu, Y.F. | Deposit date: | 2011-10-21 | Release date: | 2012-10-24 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Structural study of TTR-52 reveals the mechanism by which a bridging molecule mediates apoptotic cell engulfment Genes Dev., 26, 2012
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4ML0
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![BU of 4ml0 by Molmil](/molmil-images/mine/4ml0) | Crystal structure of E.coli DinJ-YafQ complex | Descriptor: | Predicted antitoxin of YafQ-DinJ toxin-antitoxin system, Predicted toxin of the YafQ-DinJ toxin-antitoxin system, SULFATE ION | Authors: | Liang, Y.J, Gao, Z.Q, Liu, Q.S, Dong, Y.H. | Deposit date: | 2013-09-06 | Release date: | 2014-06-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural and Functional Characterization of Escherichia coli Toxin-Antitoxin Complex DinJ-YafQ J.Biol.Chem., 289, 2014
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4MMG
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![BU of 4mmg by Molmil](/molmil-images/mine/4mmg) | crystal structure of YafQ mutant H87Q from E.coli | Descriptor: | SULFATE ION, mRNA interferase YafQ | Authors: | Liang, Y.J, Gao, Z.Q, Liu, Q.S, Dong, Y.H. | Deposit date: | 2013-09-09 | Release date: | 2014-06-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural and Functional Characterization of Escherichia coli Toxin-Antitoxin Complex DinJ-YafQ J.Biol.Chem., 289, 2014
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4ML2
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![BU of 4ml2 by Molmil](/molmil-images/mine/4ml2) | Crystal structure of wild-type YafQ | Descriptor: | SULFATE ION, mRNA interferase YafQ | Authors: | Liang, Y.J, Gao, Z.Q, Liu, Q.S, Dong, Y.H. | Deposit date: | 2013-09-06 | Release date: | 2014-06-25 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural and Functional Characterization of Escherichia coli Toxin-Antitoxin Complex DinJ-YafQ J.Biol.Chem., 289, 2014
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5GNI
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![BU of 5gni by Molmil](/molmil-images/mine/5gni) | |