7V3S

Crystal structure of CMET in complex with a novel inhibitor

Summary for 7V3S

Entry DOI	10.2210/pdb7v3s/pdb
Descriptor	Hepatocyte growth factor receptor, ~{N}1'-[3-fluoranyl-4-(10~{H}-pyrido[3,2-b][1,4]benzoxazin-4-yloxy)phenyl]-~{N}1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (3 entities in total)
Functional Keywords	transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	36548.07
Authors	Su, H.X.,Liu, Q.F.,Chen, T.T.,Li, M.J.,Xu, Y.C. (deposition date: 2021-08-11, release date: 2022-08-17, Last modification date: 2023-11-29)
Primary citation	Zhan, Z.,Ji, Y.,Su, H.,Fang, C.,Peng, X.,Liu, Q.,Dai, Y.,Lin, D.,Xu, Y.,Ai, J.,Duan, W. Discovery of 10H-Benzo[b]pyrido[2,3-e][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase J.Med.Chem., 66:220-234, 2023 Cited by DOI: 10.1021/acs.jmedchem.2c00962 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation