7V3S

Crystal structure of CMET in complex with a novel inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Hepatocyte growth factor receptor	polymer	319	36033.6	1	UniProt (P08581) Pfam (PF07714) In PDB	Homo sapiens (Human)	HGF receptor,HGF/SF receptor,Proto-oncogene c-Met,Scatter factor receptor,SF receptor,Tyrosine-protein kinase Met
2	A	~{N}1'-[3-fluoranyl-4-(10~{H}-pyrido[3,2-b][1,4]benzoxazin-4-yloxy)phenyl]-~{N}1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide	non-polymer		514.5	1	Chemie (5I9)
3		water	water		18.0	281	Chemie (HOH)

Sequence modifications

A: 1038 - 1346 (UniProt: P08581)

PDB	External Database	Details
Met 1028	-	initiating methionine
Gly 1029	-	expression tag
Ser 1030	-	expression tag
Ser 1031	-	expression tag
His 1032	-	expression tag
His 1033	-	expression tag
His 1034	-	expression tag
His 1035	-	expression tag
His 1036	-	expression tag
His 1037	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36033.6
Non-Polymers*	Number of molecules	1
	Total formula weight	514.5
All*	Total formula weight	36548.1

*Water molecules are not included.