7LK1
| Ornithine Aminotransferase (OAT) with its potent inhibitor - (S)-3-amino-4,4-difluorocyclopent-1-enecarboxylic acid (SS-1-148) - 1 Hour Soaking | 分子名称: | (1R,4R)-4-fluoro-3-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]cyclopent-2-ene-1-carboxylic acid, Ornithine aminotransferase, mitochondrial | 著者 | Butrin, A, Shen, S, Liu, D, Silverman, R. | 登録日 | 2021-02-01 | 公開日 | 2022-02-16 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Turnover and Inactivation Mechanisms for ( S )-3-Amino-4,4-difluorocyclopent-1-enecarboxylic Acid, a Selective Mechanism-Based Inactivator of Human Ornithine Aminotransferase. J.Am.Chem.Soc., 143, 2021
|
|
7LON
| Ornithine Aminotransferase (OAT) cocrystallized with its inactivator - (1S,3S)-3-amino-4-(difluoromethylene)cyclohexene-1-carboxylic acid | 分子名称: | (1R,3S,4R)-3-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-4-methylcyclohexane-1-carboxylic acid, Ornithine aminotransferase, mitochondrial, ... | 著者 | Butrin, A, Zhu, W, Liu, D, Silverman, R. | 登録日 | 2021-02-10 | 公開日 | 2021-08-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Remarkable and Unexpected Mechanism for ( S )-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase. J.Am.Chem.Soc., 143, 2021
|
|
7LOM
| Ornithine Aminotransferase (OAT) soaked with its inactivator - (1S,3S)-3-amino-4-(difluoromethylene)cyclohexene-1-carboxylic acid | 分子名称: | (3~{S},4~{S})-4-methyl-3-[[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylamino]cyclohexene-1-carboxylic acid, (4~{R})-4-(fluoranylmethyl)-3-[[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylamino]cyclohexene-1-carboxylic acid, Ornithine aminotransferase, ... | 著者 | Butrin, A, Zhu, W, Liu, D, Silverman, R. | 登録日 | 2021-02-10 | 公開日 | 2021-08-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Remarkable and Unexpected Mechanism for ( S )-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase. J.Am.Chem.Soc., 143, 2021
|
|
7ULU
| Human DDAH1 soaked with its inhibitor ClPyrAA | 分子名称: | (2S)-2-amino-4-[(pyridin-2-yl)amino]butanoic acid, N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 | 著者 | Butrin, A, Zheng, Y, Tuley, A, Liu, D, Fast, W. | 登録日 | 2022-04-05 | 公開日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Optimization of a switchable electrophile fragment into a potent and selective covalent inhibitor of human DDAH1 To Be Published
|
|
7ULX
| Human DDAH1 soaked with its inhibitor N4-(4-chloropyridin-2-yl)-L-asparagine | 分子名称: | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1, N-(pyridin-2-yl)-L-asparagine | 著者 | Zheng, Y, Butrin, A, Tuley, A, Liu, D, Fast, W. | 登録日 | 2022-04-05 | 公開日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.707 Å) | 主引用文献 | Optimization of a switchable electrophile fragment into a potent and selective covalent inhibitor of human DDAH1 To Be Published
|
|
7ULV
| Human DDAH1 soaked with its inactivator S-((4-chloropyridin-2-yl)methyl)-L-cysteine | 分子名称: | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1, S-[(pyridin-2-yl)methyl]-L-cysteine | 著者 | Zheng, Y, Butrin, A, Tuley, A, Liu, D, Fast, W. | 登録日 | 2022-04-05 | 公開日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | 主引用文献 | Optimization of a switchable electrophile fragment into a potent and selective covalent inhibitor of human DDAH1 To Be Published
|
|
3RZ2
| Crystal of Prl-1 complexed with peptide | 分子名称: | Prl-1 (PTP4A1), Protein tyrosine phosphatase type IVA 1 | 著者 | Zhang, Z.-Y, Liu, D, Bai, Y. | 登録日 | 2011-05-11 | 公開日 | 2011-10-26 | 最終更新日 | 2014-10-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein. J.Biol.Chem., 286, 2011
|
|
7WJU
| Cryo-EM structure of the AsCas12f1-sgRNAv1-dsDNA ternary complex | 分子名称: | Non-target strand, OrfB_Zn_ribbon domain-containing protein, Target strand, ... | 著者 | Wu, Z, Liu, D, Shen, H, Ji, Q. | 登録日 | 2022-01-07 | 公開日 | 2023-01-18 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.69 Å) | 主引用文献 | Structure-directed functional evolution of the miniature CRISPR-AsCas12f1 system To Be Published
|
|
7W9K
| Cryo-EM structure of human Nav1.7-beta1-beta2 complex at 2.2 angstrom resolution | 分子名称: | (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | Yan, N, Huang, G, Liu, D, Wei, P, Shen, H. | 登録日 | 2021-12-09 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | High-resolution structures of human Na v 1.7 reveal gating modulation through alpha-pi helical transition of S6 IV. Cell Rep, 39, 2022
|
|
7W9P
| Cryo-EM structure of human Nav1.7(E406K) in complex with auxiliary beta subunits, huwentoxin-IV and saxitoxin (S6IV pi helix conformer) | 分子名称: | (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | Yan, N, Huang, G, Liu, D, Wei, P, Shen, H. | 登録日 | 2021-12-10 | 公開日 | 2022-05-25 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | High-resolution structures of human Na v 1.7 reveal gating modulation through alpha-pi helical transition of S6 IV. Cell Rep, 39, 2022
|
|
7W9M
| Cryo-EM structure of human Nav1.7(E406K) in complex with auxiliary beta subunits, ProTx-II and tetrodotoxin (S6IV pi helix conformer) | 分子名称: | (1R,5R,6R,7R,9S,11S,12S,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol (non-preferred name), 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yan, N, Huang, G, Liu, D, Wei, P, Shen, H. | 登録日 | 2021-12-10 | 公開日 | 2022-05-25 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | High-resolution structures of human Na v 1.7 reveal gating modulation through alpha-pi helical transition of S6 IV. Cell Rep, 39, 2022
|
|
7W9L
| Cryo-EM structure of human Nav1.7(E406K)-beta1-beta2 complex | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | Yan, N, Huang, G, Liu, D, Wei, P, Shen, H. | 登録日 | 2021-12-10 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | High-resolution structures of human Na v 1.7 reveal gating modulation through alpha-pi helical transition of S6 IV. Cell Rep, 39, 2022
|
|
7W9T
| Cryo-EM structure of human Nav1.7(E406K) in complex with auxiliary beta subunits, huwentoxin-IV and saxitoxin (S6IV alpha helix conformer) | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | Yan, N, Huang, G, Liu, D, Wei, P. | 登録日 | 2021-12-10 | 公開日 | 2022-05-25 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | High-resolution structures of human Na v 1.7 reveal gating modulation through alpha-pi helical transition of S6 IV. Cell Rep, 39, 2022
|
|
7YBU
| Human propionyl-coenzyme A carboxylase | 分子名称: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Propionyl-CoA carboxylase alpha chain, mitochondrial, ... | 著者 | Su, J.Y, Liu, D.S. | 登録日 | 2022-06-29 | 公開日 | 2023-07-05 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Human propionyl-coenzyme A carboxylase To Be Published
|
|
7JH4
| Crystal structure of NAD(P)H-flavin oxidoreductase (NfoR) from S. aureus complexed with reduced FMN and NAD+ | 分子名称: | 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, NAD(P)H-dependent oxidoreductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Zheng, Y, O'Neill, A.G, Beaupre, B.A, Liu, D, Moran, G.R. | 登録日 | 2020-07-20 | 公開日 | 2020-09-16 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | NfoR: Chromate Reductase or Flavin Mononucleotide Reductase? Appl.Environ.Microbiol., 86, 2020
|
|
7EZO
| |
6BQR
| Human TRPM4 ion channel in lipid nanodiscs in a calcium-free state | 分子名称: | CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 4 | 著者 | Autzen, H.E, Myasnikov, A.G, Campbell, M.G, Asarnow, D, Julius, D, Cheng, Y. | 登録日 | 2017-11-28 | 公開日 | 2017-12-20 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structure of the human TRPM4 ion channel in a lipid nanodisc. Science, 359, 2018
|
|
6BQV
| Human TRPM4 ion channel in lipid nanodiscs in a calcium-bound state | 分子名称: | CALCIUM ION, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 4 | 著者 | Autzen, H.E, Myasnikov, A.G, Campbell, M.G, Asarnow, D, Julius, D, Cheng, Y. | 登録日 | 2017-11-28 | 公開日 | 2017-12-20 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure of the human TRPM4 ion channel in a lipid nanodisc. Science, 359, 2018
|
|
6O20
| Cryo-EM structure of TRPV5 with calmodulin bound | 分子名称: | CALCIUM ION, Calmodulin, Transient receptor potential cation channel subfamily V member 5 | 著者 | Dang, S, van Goor, M.K, Asarnow, D, Wang, Y, Julius, D, Cheng, Y, van der Wijst, J. | 登録日 | 2019-02-22 | 公開日 | 2019-04-24 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural insight into TRPV5 channel function and modulation. Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
6O1N
| Cryo-EM structure of TRPV5 (1-660) in nanodisc | 分子名称: | Transient receptor potential cation channel subfamily V member 5 | 著者 | Dang, S, van Goor, M.K, Asarnow, D, Wang, Y, Julius, D, Cheng, Y, van der Wijst, J. | 登録日 | 2019-02-21 | 公開日 | 2019-04-24 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural insight into TRPV5 channel function and modulation. Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
6O1U
| Cryo-EM structure of TRPV5 W583A in nanodisc | 分子名称: | Transient receptor potential cation channel subfamily V member 5 | 著者 | Dang, S, van Goor, M.K, Asarnow, D, Wang, Y, Julius, D, Cheng, Y, van der Wijst, J. | 登録日 | 2019-02-21 | 公開日 | 2019-04-24 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural insight into TRPV5 channel function and modulation. Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
6O1P
| Cryo-EM structure of full length TRPV5 in nanodisc | 分子名称: | Transient receptor potential cation channel subfamily V member 5 | 著者 | Dang, S, van Goor, M.K, Asarnow, D, Wang, Y, Julius, D, Cheng, Y, van der Wijst, J. | 登録日 | 2019-02-21 | 公開日 | 2019-04-24 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural insight into TRPV5 channel function and modulation. Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
6O6R
| Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, AMTB-bound state | 分子名称: | (1R)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(heptanoyloxy)methyl]ethyl octadecanoate, CHOLESTEROL HEMISUCCINATE, N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-[(thiophen-2-yl)methyl]benzamide, ... | 著者 | Diver, M.M, Cheng, Y, Julius, D. | 登録日 | 2019-03-07 | 公開日 | 2019-09-18 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural insights into TRPM8 inhibition and desensitization. Science, 365, 2019
|
|
6O6A
| Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, ligand-free state | 分子名称: | CHOLESTEROL HEMISUCCINATE, SODIUM ION, Transient receptor potential cation channel subfamily M member 8 | 著者 | Diver, M.M, Cheng, Y, Julius, D. | 登録日 | 2019-03-05 | 公開日 | 2019-09-18 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural insights into TRPM8 inhibition and desensitization. Science, 365, 2019
|
|
6O72
| Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, TC-I 2014-bound state | 分子名称: | (1R)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(heptanoyloxy)methyl]ethyl octadecanoate, 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Diver, M.M, Cheng, Y, Julius, D. | 登録日 | 2019-03-07 | 公開日 | 2019-09-18 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural insights into TRPM8 inhibition and desensitization. Science, 365, 2019
|
|